A5082709622- Neurotransmitter Receptor Influence on Behavior
- Obsessive-Compulsive Spectrum Disorders
- Autism Spectrum Disorder Research
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Axon Guidance and Neuronal Signaling
- Stress Responses and Cortisol
- Pain Management and Placebo Effect
- Neuroendocrine regulation and behavior
- Psychedelics and Drug Studies
- Schizophrenia research and treatment
- Tryptophan and brain disorders
- Circadian rhythm and melatonin
- Genetics, Aging, and Longevity in Model Organisms
- Photoreceptor and optogenetics research
- Treatment of Major Depression
Czech Academy of Sciences
2018-2021
Czech Academy of Sciences, Institute of Physiology
2018-2021
Charles University
2021
The McGill-R-Thy1-APP transgenic rat is an animal model of the familial form Alzheimer's disease (AD), mirroring many neuropathological hallmarks and gradual deterioration cognitive functions. In this study, we describe thorough characterization in several domains. On behavioral level, report normal locomotor activity spontaneous exploration, but problems with balance or gait coordination, increased anxiety severely impaired spatial cognition 4 - 7 months old animals. profile social behavior...
Quinpirole (QNP) sensitization is a well-established model of stereotypical checking relevant to obsessive-compulsive disorder. Previously, we found that QNP-treated rats display deficits in hippocampus-dependent tasks. The present study explores the expression immediate early genes (IEG) during QNP-induced hippocampus, anterior cingulate cortex (ACC), orbitofrontal (OFC), and medial prefrontal (mPFC). Adult male were injected with QNP (0.5 mg/mL/kg; n = 15) or saline (n 14) daily for 10...
Chronic sensitization to serotonin 1A and 7 receptors agonist 8-OH-DPAT induces compulsive checking perseverative behavior. As such, it has been used model obsessive-compulsive disorder (OCD)-like behavior in mice rats. In this study, we tested spatial learning the of OCD effect co-administration memantine riluzole—glutamate-modulating agents that have shown be effective several clinical trials. Rats were active place avoidance task Carousel maze, where they learned avoid visually...
ABSTRACT Regulation of axon guidance and pruning inappropriate synapses by class 3 semaphorins is key to development neural circuits. Collapsin response mediator protein 2 (CRMP2) has been shown regulate mediating Semaphorin 3A (Sema3A) signaling its dysfunction linked schizophrenia, however, nothing known about role in the synapse pruning. Here, using newly generated crmp2 −/− mice we demonstrate that while CRMP2 only a moderate effect on Sema3A-dependent vivo , it essential for...