A5032620811- Metal complexes synthesis and properties
- Chemical Reaction Mechanisms
- Lanthanide and Transition Metal Complexes
- Molecular Sensors and Ion Detection
- Organophosphorus compounds synthesis
- Pesticide Exposure and Toxicity
- Inorganic and Organometallic Chemistry
- biodegradable polymer synthesis and properties
- Magnetism in coordination complexes
- Environmental Toxicology and Ecotoxicology
- Thermal and Kinetic Analysis
- Pesticide and Herbicide Environmental Studies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Chemical Synthesis and Characterization
- Additive Manufacturing and 3D Printing Technologies
- 3D Printing in Biomedical Research
- Porphyrin and Phthalocyanine Chemistry
- Advanced Polymer Synthesis and Characterization
- Chemical Synthesis and Reactions
- Coordination Chemistry and Organometallics
- Polymer Surface Interaction Studies
- Concrete and Cement Materials Research
- Oxidative Organic Chemistry Reactions
- Metal-Organic Frameworks: Synthesis and Applications
- Alkaline Phosphatase Research Studies
Defence Science and Technology Laboratory
2009-2023
Salisbury University
2011
King's College London
2009
Rutherford Appleton Laboratory
2009
Cardiff University
2009
University of Bristol
2009
University of St Andrews
1991-1998
University of Stirling
1987
An open-source reaction simulator was designed to benchmark the performance of multi-objective optimisation algorithms using chemistry-inspired test problems, which validated an experimental self-optimisation platform.
A lanthanum macrocycle is shown to be an effective catalyst for the hydrolysis of phosphate triester 2,4-dinitrophenyl diethyl phosphate, at pH 9 rate enhancement using 2.5 × 10–3 mol dm–3 25 °C being ca. 103-fold; reaction catalytic rather than stoicheiometric, and possible mechanisms are considered account catalysis.
The rates of catalytic oxidative decontamination the chemical warfare agent (CWA) sulfur mustard (HD, bis(2-chlororethyl) sulfide) and a range (chloroethyl) sulfide simulants variable lipophilicity have been examined using hydrogen peroxide-based microemulsion system. SANS (small-angle neutron scattering), SAXS X-ray PGSE-NMR (pulsed-gradient spin-echo NMR), fluorescence quenching, electrospray mass spectroscopy (ESI-MS) were implemented to examine distribution HD, its simulants, their...
Automated platforms allow for rapid, detailed screening of chemical systems.
The direct immobilization and destruction of two compounds relevant to chemical warfare agents, ethyl methylphosphonic acid (EMPA) thiodiglycol (TDG), within a freshly mixed Portland cement paste was studied. Cement hydration phase formation were analyzed determine the upper limits on loading these chemicals achievable in an setting. EMPA, degradation product nerve agent VX, alters cements, allowing calcium aluminate dissolution while retarding silicate clinker phases. This yielded...
We present a new methodology for the generation of discrete molecularly dispersed enzyme–polymer–surfactant bioconjugates. Significantly, we demonstrate that >3-fold increase in catalytic efficiency diffusion-limited phosphotriesterase arPTE can be achieved through sequential electrostatic addition cationic and anionic polymer surfactants, respectively. Here, surfactants assemble on surface enzyme via ion exchange to yield compact corona. The observed rate enhancement is consistent with...
Here, we describe a facile route to the synthesis of enzymatically active highly fabricable plastics, where enzyme is an intrinsic component material. This facilitated by formation electrostatically stabilized enzyme–polymer surfactant nanoconstruct, which, after lyophilization and melting, affords stable macromolecular dispersions in wide range organic solvents. A selection plastics can then be co-dissolved dispersions, which provides bespoke 3D plastic nanocomposite structures using...
To establish a basis for rapid remediation of large areas contaminated with Bacillus anthracis spores.Representative surfaces wood, steel and cement were coated by nebulization B. thuringiensis HD-1 cry- (a simulant anthracis) at 5.9 ± 0.2, 6.3 0.2 5.8 log10 CFU per cm2 , respectively. These sprayed formaldehyde, either or without pre-germination. Low volume (equivalent to ≤2500 L ha-1 ) applications formaldehyde 30 g l-1 resulted in ≥4 ≤2 reductions respectively, after 2 h exposure....
The ligand 14,14,16-trimethyl-2,6-dithia-13,17-diazatricyclo[16.4.0.07,12]docosa-1(18),7(12),8,10,16,19,21-heptaene (L) has been prepared by hydrolysis of the nickel(II) complex [NiLBr2]. A variety copper(II) complexes CuL(ClO4)2, CuLBr2, CuLCl2, CuL(NO3)2·H2O, and CuL(O2CMe)2 have characterised their spectroscopic properties studied. do not display a reversible CuII–CuI couple in acetonitrile solution, presumably as result rigid nature macrocycle which does readily adapt to preferred...
The preparation of the tetra-amide ligand N,N,N′,N′-tetrakis(2-carbamoylethyl)ethylenediamine (H2L) by Michael addition ethylenediamine to acrylamide is described. forms complexes with CuII, NiII, CoII, FeII, MnII, BaII, ZnII, CdII, HgII, and LaIII, which have been characterised in solid state. With PdII, deprotonated [ML] can be prepared solution For other metal ions formulated as Mn+(H2L)Cln·xH2O. stepwise protonation has studied potentiometric titration, giving log K1= 7.20(1) K2= 3.25(2)...
The hydrolysis of the phosphotriester 2,4-dinitrophenyl diethyl phosphate to give is catalysed by copper(II) complex [Cu(dpa)- (OH2)2]2+ (dpa = 2,2'-dipyridylamine). kinetics have been studied over pH range 5.82-7.5 and pH-rate profile indicates that catalytically active species hydroxo-aqua [Cu(dpa)(OH)(OH2)]+. reaction catalytic exhibits turnover. triester can be interpreted in terms formation a mixed ligand which phosphoryl oxygen displaces labile water molecule on [Cu(dpa)(OH)(OH2)]+...
A small-scale study with Mosi-guard Natural spray, an insect repellent containing Citriodiol, was performed to determine if it has virucidal activity against SARS-CoV-2. liquid test examined the of and individual components for activity. surface contact looked at when impregnated on a latex as synthetic skin potential topical prophylactic application. Both spray well other repellent, had in test. On used simulate treated skin, titre SARS-CoV-2 less over time Natural-treated but virus still recovered.