A5100380388- Orthopaedic implants and arthroplasty
- Prosthetics and Rehabilitation Robotics
- Tendon Structure and Treatment
- Shoulder Injury and Treatment
- Hip disorders and treatments
- Total Knee Arthroplasty Outcomes
- Hip and Femur Fractures
- Orthopedic Surgery and Rehabilitation
- Elbow and Forearm Trauma Treatment
- Genetic Syndromes and Imprinting
- Vitamin D Research Studies
- Effects of Radiation Exposure
- Sirtuins and Resveratrol in Medicine
- Head and Neck Cancer Studies
- Bone fractures and treatments
- Fibroblast Growth Factor Research
- Bone health and osteoporosis research
- Diabetic Foot Ulcer Assessment and Management
- Sports injuries and prevention
- Parathyroid Disorders and Treatments
- RNA Interference and Gene Delivery
- Bone Metabolism and Diseases
- Telomeres, Telomerase, and Senescence
- Nonmelanoma Skin Cancer Studies
Karolinska Institutet
2008-2023
Karolinska University Hospital
2013-2023
In vitro replicative senescence affects MSC characteristics and functionality, thus severely restricting their application in regenerative medicine MSC-based therapies. Previously, we found that natural is accompanied by altered intracellular nicotinamide adenine dinucleotide (NAD+) metabolism, which Nampt plays a key role. However, whether influences still unclear. Our study showed expression down-regulated during senescence. depletion via specific inhibitor FK866 or knockdown early passage...
Tendinopathies are often empirically treated with oral/topical nonsteroidal anti-inflammatory medications and corticosteroid injections despite their unclear effects on tendon regeneration. Recent studies indicate that progenitors exhibit stem cell-like properties, i.e., differentiation to osteoblasts, adipocytes, chondrocytes, in addition tenocytes. Our present study aims at understanding the of triamcinolone acetonide diclofenac tenocytic mesenchymal cells. The murine fibroblast C3H10T1/2...
The direct attachment of the osseointegrated prosthesis to skeleton avoids inherent problems socket suspension. It also permits physiological weight bearing, improved range motion in proximal joint, and osseoperceptive sensor feedback, enabling better control artificial limb by amputees. This article describes osseointegration program Sweden based on use bone-anchored prostheses for transfemoral amputation rehabilitation. authors discuss detail patient-centered evaluation, surgical...
Although distal radius fracture (DRF) is the most common type in children, research on its seasonality across different age groups limited. We investigated secular trends incidence and seasonal variation of pediatric DRF based Swedish nationwide population database. In this observational study, data for all children aged <18 years Sweden with defined by ICD-codes were analyzed each month year during 2002–2016 using National Patient Register. The general counts sex-category acquired to...
Radiodermatitis is an inevitable side effect of radiotherapy in cancer treatment and there currently no consensus on effective drugs for treating the condition. Vitamin B12 known to be repairing regenerating damaged skin. However, are few studies use radiodermatitis. This study explored therapeutic efficacy mechanism action ointment A porcine model grade IV radiodermatitis was established. The applied 12 weeks after which histological staining, transmission electron microscopy, RT-qPCR,...