A5046169689- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Synthetic Organic Chemistry Methods
- Marine Sponges and Natural Products
- Traditional and Medicinal Uses of Annonaceae
- Bioactive Compounds and Antitumor Agents
- Asymmetric Synthesis and Catalysis
- Advanced Sensor and Energy Harvesting Materials
- Crystallography and molecular interactions
- Oxidative Organic Chemistry Reactions
- Axial and Atropisomeric Chirality Synthesis
- Synthesis and Catalytic Reactions
- Advanced Chemical Sensor Technologies
- Polydiacetylene-based materials and applications
- Chemical synthesis and alkaloids
- Synthesis of Organic Compounds
Baylor University
2022-2023
University of Illinois Urbana-Champaign
2016-2021
University of Illinois System
2021
A soft, skin-mounted microfluidic device captures microliter volumes of sweat and quantitatively measures biochemical markers by colorimetric analysis.
The sesquiterpene-tropolones belong to a distinctive structural class of meroterpene natural products with impressive biological activities, including anticancer, antifungal, antimalarial, and antibacterial. In this article, we describe concise, modular, cycloaddition-based approach series sesquiterpene mono- bistropolones, (−)-epolone B, (+)-isoepolone (±)-dehydroxypycnidione, (−)-10-epi-pycnidione. Alongside the development general strategy access unique family metabolites were...
Described herein are the first total syntheses of (±)-dracocephalone A (1) and (±)-dracocequinones (4) B (5). The synthesis was initially envisioned as proceeding through an intramolecular isobenzofuran Diels-Alder reaction, a strategy that eventually evolved into Lewis acid-promoted spirocyclization. This highly diastereoselective transformation set stage for trans-decalin formation late-stage Suárez oxidation produced [3.2.1] oxabicycle suited conversion to 1. Brønsted acid-mediated...
Described herein is an asymmetric synthesis of a functionalized 1,2,3-trisubstituted cyclopentane building block, derivatives which are commonly found in numerous natural products. Key steps include Lewis-acid-mediated cyclobutane ring opening, diastereoselective chlorination, and Favorskii rearrangement.
Described herein is an asymmetric synthesis of a functionalized 1,2,3-trisubstituted cyclopentane building block, derivatives which are commonly found in numerous natural products. Key steps include Lewis acid-mediated cyclobutane ring opening, diastereoselective chlorination, and Favorskii rearrangement.
Abstract Described herein are the first total syntheses of (±)‐dracocephalone A ( 1 ) and (±)‐dracocequinones 4 B 5 ). The synthesis was initially envisioned as proceeding through an intramolecular isobenzofuran Diels–Alder reaction, a strategy that eventually evolved into Lewis acid‐promoted spirocyclization. This highly diastereoselective transformation set stage for trans ‐decalin formation late‐stage Suárez oxidation produced [3.2.1] oxabicycle suited conversion to . Brønsted...