A5085711819- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Influenza Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- RNA and protein synthesis mechanisms
- Evolution and Genetic Dynamics
- SARS-CoV-2 detection and testing
- Animal Virus Infections Studies
- Bacterial Identification and Susceptibility Testing
- Salmonella and Campylobacter epidemiology
- Travel-related health issues
- CAR-T cell therapy research
- Genomics and Rare Diseases
- Herpesvirus Infections and Treatments
- COVID-19 epidemiological studies
- Tuberculosis Research and Epidemiology
- Pharmacological Receptor Mechanisms and Effects
- Cancer Genomics and Diagnostics
- Mycobacterium research and diagnosis
- Infectious Diseases and Tuberculosis
- Viral Infectious Diseases and Gene Expression in Insects
- Molecular Biology Techniques and Applications
- Virology and Viral Diseases
Wadsworth Center
2009-2024
New York State Department of Health
2009-2024
University at Albany, State University of New York
2021
For Salmonella enterica serovar Enteritidis, 85% of isolates can be classified into 5 pulsed-field gel electrophoresis (PFGE) types. However, PFGE has limited discriminatory power for outbreak detection. Although whole-genome sequencing been found to improve discrimination clusters, whether this procedure used in real-time a public health laboratory is not known. Therefore, we conducted retrospective and prospective analysis. The study investigated from 1 confirmed outbreak. Additional cases...
ABSTRACT Whole-genome sequencing (WGS) is a newer alternative for tuberculosis (TB) diagnostics and capable of providing rapid drug resistance profiles while performing species identification capturing the data necessary genotyping. Our laboratory developed validated comprehensive sensitive WGS assay to characterize Mycobacterium other M. complex (MTBC) strains, composed novel DNA extraction, optimized library preparation, paired-end WGS, an in-house-developed bioinformatics pipeline. This...
SARS-CoV-2 variants shaped the second year of COVID-19 pandemic and discourse around effective control measures. Evaluating threat posed by a new variant is essential for adapting response efforts when community transmission detected. In this study, we compare dynamics two variants, Alpha Iota, integrating genomic surveillance data to estimate reproduction number (R
Abstract During the 2014–15 influenza season, 13/168 respiratory samples from students with influenza-like illness (ILI) at a college in New York, USA, were positive for human adenovirus (HAdV); 4/13 HAdV-B14p1. HAdV should be included differential diagnostic panel used to determine etiology of ILI.
Summary The emergence and spread of SARS-CoV-2 lineage B.1.1.7, first detected in the United Kingdom, has become a global public health concern because its increased transmissibility. Over 2500 COVID-19 cases associated with this variant have been US since December 2020, but extent establishment is relatively unknown. Using travel, genomic, diagnostic data, we highlight primary ports entry for B.1.1.7 locations possible underreporting cases. Furthermore, found evidence many independent...
This manuscript describes the development of a streamlined, cost-effective laboratory workflow to meet demands increased whole genome sequence (WGS) capacity while achieving mandated quality metrics. From 2020 2021, Wadsworth Center Bacteriology Laboratory (WCBL) used streamlined 5,743 genomes that contributed data nine different projects. The combined use QIAcube HT, Illumina DNA Prep using quarter volume reactions, and NextSeq allowed WCBL process all samples required WGS also median...
The need for effective influenza antiviral susceptibility surveillance methods has increased due to the emergence of near-universal adamantane resistance in A/H3N2 viruses during 2005-2006 season and appearance oseltamivir A/H1N1 virus subtype 2007-2008 season. two classes antivirals, neuraminidase inhibitors (NAIs) adamantanes, are well characterized, as many mutations that can confer these drugs. Adamantane is imparted mainly by a S31N mutation matrix gene, while NAI result from number...
Ocular infections caused by human adenovirus (HAdV) are highly contagious. The most severe usually members of species HAdV‐D (types HAdV8, 19, 37, 53, 54, and 56) can manifest as epidemic keratoconjunctivitis (EKC), often resulting in prolonged impairment vision. During the early months 2012, EKC outbreaks occurred neonatal intensive care units (NICUs) 3 hospitals New York State (New Suffolk Counties). A total 32 neonates were affected. For 14 them, HAdV8 was laboratory‐confirmed causative...
Abstract Emerging SARS-CoV-2 variants have shaped the second year of COVID-19 pandemic and public health discourse around effective control measures. Evaluating threat posed by a new variant is essential for appropriately adapting response efforts when community transmission detected. However, this assessment requires that true comparison can be made between its predecessors because factors other than virus genotype may influence spread transmission. In study, we develop framework integrates...