A5074462265- Vitamin D Research Studies
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Vitamin C and Antioxidants Research
- Adipose Tissue and Metabolism
- Obesity, Physical Activity, Diet
- Nutritional Studies and Diet
- Muscle metabolism and nutrition
- Child Nutrition and Feeding Issues
- Dysphagia Assessment and Management
- Diet, Metabolism, and Disease
- Regulation of Appetite and Obesity
- Thermoregulation and physiological responses
- Nutrition and Health in Aging
- Amyotrophic Lateral Sclerosis Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Prostate Cancer Diagnosis and Treatment
- Reproductive System and Pregnancy
- Eating Disorders and Behaviors
- Tryptophan and brain disorders
- Bone health and osteoporosis research
- Biochemical effects in animals
- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Liver Disease Diagnosis and Treatment
Curtin University
2013-2024
North Metropolitan Health Service
2023-2024
South Metropolitan Health Service
2023-2024
Abstract Background Haematological cancer affects more than 1.3 million people around the world annually and accounted for almost 800,000 deaths globally in 2020. The number of patients with these cancers undergoing bone marrow transplant is increasing. Of note, this intensive treatment associated complex multifactorial side effects, often impacting nutritional status, physical functioning overall health-related quality life. primary aim study to investigate effectiveness an eight-week...
Circulating peripheral blood mononuclear cells (PBMCs) are exposed to metabolic and immunological stimuli that influence their functionality. We hypothesized prevailing vitamin D status [25(OH)D] would modulate the bioenergetic profile of PBMCs derived from humans. 38 participants (16 males, 22 females) ranging in body fat 14–51% were studied. isolated whole blood, counted freshly seeded for analysis using Seahorse XFe96 flux analyser. Whole energy metabolism via indirect calorimetry,...
Circulating immune cells are considered a source for biomarkers in health and disease, since they exposed to nutritional, metabolic immunological stimuli the vasculature. Cryopreservation of leucocytes is routinely used long-term storage determination phenotypic/functional changes at later date. Exploring role bioenergetics mitochondrial (dys)function often examined by using freshly isolated cells. The aim pilot study described herein was assess leucocyte cryopreserved Leucocytes were from...
Vitamin D status [25(OH)D] has recently been reported to be associated with altered cellular bioenergetic profiles of peripheral blood mononuclear cells (PBMCs). No study tracked the seasonal variation 25(OH)D and its putative influence on whole body energy metabolism, profiles, inflammatory markers clinical chemistry.Whole metabolism substrate utilisation were measured by indirect calorimetry. PBMCs obtained from same subjects isolated blood, counted freshly seeded. Bioenergetic analysis...
We determined whether metabolic syndrome (MetS) and the increasing number of its components influenced resting energy expenditure (REE). Data on adult men (n = 72, 40%) women 108, 60%) from European 154, 86%) Sub-Saharan African 26, 14%) ancestry were used. Ninety-five (53%) participants had MetS (MetS+), while 85 (47%) without (MetS−). REE was through indirect calorimetry, body composition by DEXA, clinical biochemistry standard laboratory techniques. MetS+ a significantly higher (mean ±...
Abstract Background The role of vitamin D in human energy expenditure requires confirmation. We explored whether insulin sensitivity (IS)/insulin resistance (IR) mediated the association status (25OHD) on resting (REE). Methods REE, body composition (by DEXA) and clinical biochemistry 155 Australian men women were collated. A hypothesized mediation pathway through IS/IR direct between 25OHD REE was modeled, using three surrogate indices IS/IR: McAuley’s index (McA), Quantitative check...
L-Leucine (Leu) supplementation may benefit fat-free mass (FFM) per se and glucose metabolism.
To determine the acute effect of a mild cold exposure on thermoregulatory thermogenesis and role circulating irisin in process.We studied 22 adults (9 males, 13 females) aged 57.7 ± 10.07 years body mass index 27.8 4.52 kg/m(2) . Participants experienced 90-min to 20°C 25°C randomized cross-over design. Resting metabolic rate (RMR), forearm finger-tip gradient (FFG), blood pressure (BP), in-the-ear temperature (IET), fasting bloods were measured each occasion.There significant increases FFG...
Abstract Introduction/Aims Enteral feeding via gastrostomy is a key intervention to prevent significant weight loss in Motor Neuron Disease (MND). The aim of this study was explore demographic, clinical, and nutritional factors associated with survival time MND patients gastrostomy. Methods retrospective analyzed 94 ( n = 58 bulbar‐onset 36 limb‐onset) who underwent between 2015 2021. primary outcome the from insertion death. Independent variables interest explored were: age at insertion,...
Abstract Introduction/Aims Motor neuron disease (MND) is a progressive neurodegenerative condition with limited life expectancy. There very little data on mortality and its associated factors beyond 30 days following gastrostomy. We explored the demographic, clinical, nutritional predictors for early at 30, 90, 180 gastrostomy in these patients. Methods This was retrospective study involving 94 MND patients Western Australia who underwent between 2015 2021. Patients were divided into two...
<title>Abstract</title> <bold>Background.</bold> Metabolic flexibility (MF) is the capacity to switch from fat carbohydrate utilization when required, and MF constrained in metabolic syndrome (MetS). We determined whether l-leucine (Leu) supplementation enhanced resting energy expenditure (REE), respiratory quotient (RQ), MF, insulin sensitivity liver function during caloric restriction (CR). <bold>Methods.</bold> Thirty-seven participants at risk of MetS completed a parallel, double-blind...