A5029136379- COVID-19 epidemiological studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and Mental Health
- Vaccine Coverage and Hesitancy
- COVID-19 Clinical Research Studies
- Infection Control and Ventilation
- Health disparities and outcomes
- Influenza Virus Research Studies
- Respiratory viral infections research
- Viral Infections and Outbreaks Research
- Employment and Welfare Studies
- COVID-19 and healthcare impacts
- SARS-CoV-2 detection and testing
- Viral Infections and Vectors
- COVID-19 Pandemic Impacts
- Migration, Health and Trauma
- Workplace Health and Well-being
- Retinal and Optic Conditions
- Migration and Labor Dynamics
- Long-Term Effects of COVID-19
- Data-Driven Disease Surveillance
- Climate Change and Health Impacts
- Global Health Care Issues
- Bacterial Infections and Vaccines
- Radiopharmaceutical Chemistry and Applications
University College London
2020-2024
Imperial College London
2022-2024
NIHR Imperial Biomedical Research Centre
2023-2024
Institute of Informatics of the Slovak Academy of Sciences
2023
Health Data Research UK
2021-2022
The coronavirus (COVID-19) pandemic has caused significant global mortality and impacted lives around the world. Virus Watch aims to provide evidence on which public health approaches are most likely be effective in reducing transmission impact of virus, will investigate community incidence, symptom profiles COVID-19 relation population movement behaviours.Virus is a household cohort study acute respiratory infections England Wales run from June 2020 August 2021. recruit 50 000 people,...
A range of studies globally demonstrate that the effectiveness SARS-CoV-2 vaccines wane over time, but total effect anti-S antibody levels on risk infection and whether this varies by vaccine type is not well understood. Here we show peak three to four weeks following second dose geometric mean samples nine fold higher for BNT162b2 than ChAdOx1. Increasing are associated with a reduced (Hazard Ratio 0.85; 95%CIs: 0.79-0.92). We do find evidence relationship (BNT162b2 vs. ChAdOx1). In keeping...
ObjectivesSeroprevalence studies can provide a measure of SARS-CoV-2 cumulative incidence, but better understanding spike and nucleocapsid (anti-N) antibody dynamics following infection is needed to assess the longevity detectability.MethodsAdults aged ≥18 years, from households enrolled in Virus Watch prospective community cohort study England Wales, provided monthly capillary blood samples, which were tested for anti-N. Participants self-reported vaccination dates past medical history....
Abstract Background Workers across different occupations vary in their risk of SARS-CoV-2 infection, but the direct contribution occupation to this relationship is unclear. This study aimed investigate how infection differed occupational groups England and Wales up April 2022, after adjustment for potential confounding stratification by pandemic phase. Methods Data from 15,190 employed/self-employed participants Virus Watch prospective cohort were used generate ratios virologically- or...
Abstract Background Vaccination constitutes the best long-term solution against Coronavirus Disease 2019 (COVID-19). Real-world immunogenicity data are sparse, particularly for ChAdOx1 and in populations with chronic conditions; given UK’s extended dosing interval, it is also important to understand antibody responses SARS-CoV-2-naive individuals following a single dose. Methods Adults aged ≥18 years from households enrolled Virus Watch, prospective community cohort study England Wales,...
Abstract Vaccination constitutes the best long-term solution against Coronavirus Disease-2019; however, vaccine-derived immunity may not protect all groups equally, and durability of protective antibodies be short. We evaluate Spike-antibody responses following BNT162b2 or ChAdOx1-S vaccination amongst SARS-CoV2-naive adults across England Wales enrolled in a prospective cohort study (Virus Watch). Here we show recipients achieved higher peak antibody levels after two doses; both experience...
Objectives Risk of SARS-CoV-2 infection varies across occupations; however, investigation into factors underlying differential risk is limited. We aimed to estimate the total effect occupation on serological status, whether this mediated by workplace close contact, and how exposure poorly ventilated workplaces varied occupations. Methods used data from a subcohort (n=3775) adults in UK-based Virus Watch cohort study who were tested for anti-nucleocapsid antibodies (indicating natural...
Workplaces are an important potential source of SARS-CoV-2 exposure; however, investigation into workplace contact patterns is lacking. This study aimed to investigate how attendance and features varied between occupations across the COVID-19 pandemic in England.
Abstract Respiratory viruses that were suppressed through previous lockdowns during the COVID-19 pandemic have recently started to co-circulate with SARS-CoV-2. Understanding clinical characteristics and symptomatology of different respiratory viral infections can help address challenges related identification cases understanding SARS-CoV-2 variants' evolutionary patterns. Flu Watch (2006–2011) Virus (2020–2022) are household community cohort studies monitoring epidemiology influenza,...
Abstract Background SARS-CoV-2 vaccines stimulate production of antibodies targeting the spike protein (anti-S). The level following vaccination and trajectories waning may differ between influencing protection, how soon protection is reduced and, consequently optimum timing booster doses. Methods We measured anti-S titre in context seronegativity for anti-Nucleocapsid (anti-N), samples collected 1st July 24th October 2021 a subset adults Virus Watch community cohort. compared levels after...
Vaccination intention is key to the success of any vaccination programme, alongside vaccine availability and access. Public take a COVID-19 high in England Wales compared other countries, but rate disparities between ethnic, social age groups has led concern.Online survey prospective household community cohort study participants across (Virus Watch). was measured by individual participant responses 'Would you accept if offered?', collected December 2020 February 2021. Responses 13-item...
Background Differential exposure to public activities may contribute stark deprivation-related inequalities in SARS-CoV-2 infection and outcomes but has not been directly investigated. We set out investigate whether participants Virus Watch—a large community cohort study based England Wales—reported differential non-household contacts during the autumn–winter phase of COVID-19 pandemic according postcode-level socioeconomic deprivation. Methods Participants (n=20 120–25 228 across surveys)...
The serial interval is a key epidemiological measure that quantifies the time between onset of symptoms in an infector-infectee pair. It indicates how quickly new generations cases appear, thus informing on speed epidemic. Estimating requires to identify pairs infectors and infectees. Yet, most studies fail assess direction transmission assume order infections - transmissions strictly follows symptom onsets, thereby imposing intervals be positive. Because long highly variable incubation...
Abstract Introduction The Coronavirus (COVID-19) Pandemic has caused significant global mortality and impacted lives around the world. Virus Watch aims to provide evidence on which public health approaches are most likely be effective in reducing transmission impact of virus, will investigate community incidence, symptom profiles, COVID-19 relation population movement behaviours. Methods analysis is a household cohort study acute respiratory infections England & Wales run from June 2020...
<ns3:p><ns3:bold>Background:</ns3:bold> Household overcrowding is associated with increased risk of infectious diseases across contexts and countries. Limited data exist linking household COVID-19. We used collected from the Virus Watch cohort to examine association between overcrowded households SARS-CoV-2.</ns3:p><ns3:p> </ns3:p><ns3:p> <ns3:bold>Methods:</ns3:bold> The study a community acute respiratory infections in England Wales. calculated using measure persons per room for each...
Occupational disparities in COVID-19 vaccine uptake can impact the effectiveness of vaccination programmes and introduce particular risk for vulnerable workers those with high workplace exposure. This study aimed to investigate by occupation, including groups occupational exposure status.
Abstract Background Workers differ in their risk of SARS-CoV-2 infection according to occupation, but the direct contribution occupation this relationship is unclear. This study aimed investigate how differed across occupational groups England and Wales up April 2022, after adjustment for potential confounding stratification by pandemic phase. Methods Data from 15,190 employed/self-employed participants Virus Watch prospective cohort were used generate ratios virologically- or...
Abstract Background The Omicron B.1.1.529 variant increased severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in doubly vaccinated individuals, particularly the Oxford–AstraZeneca COVID-19 vaccine (ChAdOx1) recipients. To tackle infections, UK’s booster vaccination programmes used messenger ribonucleic acid (mRNA) vaccines irrespective of an individual’s primary course type, and prioritized clinically vulnerable. These mRNA included Pfizer–BioNTech (BNT162b2) Moderna...
Abstract Background It is poorly understood which workers lack access to sick pay in England and Wales. This evidence gap has been of particular interest the context Covid‐19 pandemic given relationship between presenteeism infectious disease transmission. Method cross‐sectional analysis ( n = 8874) was nested within a large community cohort study based across Wales (Virus Watch). An online survey February 2021 asked participants work if they had paid leave. We used logistic regression...
Abstract Purpose We aimed to understand which non-household activities increased infection odds and contributed greatest SARS-CoV-2 infections following the lifting of public health restrictions in England Wales. Procedures undertook multivariable logistic regressions assessing contribution reported by adult Virus Watch Community Cohort Study participants. calculated adjusted weighted population attributable fractions (aPAF) estimating activity infections. Findings Among 11 413 participants...