A5042926956- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Estrogen and related hormone effects
- interferon and immune responses
- MicroRNA in disease regulation
- Glycogen Storage Diseases and Myoclonus
- Abdominal vascular conditions and treatments
- Nanoplatforms for cancer theranostics
- Ovarian function and disorders
- Chemotherapy-related skin toxicity
- Lysosomal Storage Disorders Research
- Skin Diseases and Diabetes
- Nanoparticle-Based Drug Delivery
- Aortic Disease and Treatment Approaches
- RNA Interference and Gene Delivery
- Toxin Mechanisms and Immunotoxins
- Protease and Inhibitor Mechanisms
- Cytomegalovirus and herpesvirus research
- Heat shock proteins research
- Connexins and lens biology
- Neurosurgical Procedures and Complications
- Reproductive System and Pregnancy
- Genomics, phytochemicals, and oxidative stress
- Dendrimers and Hyperbranched Polymers
- Biochemical and Molecular Research
Shanghai Jiao Tong University
2021-2024
Inner Mongolia Agricultural University
2019-2023
Fujian Medical University
2021
Union Hospital
2021
Traditional experimental high-throughput screening (HTS) methods, exemplified by CRISPR-based techniques, have revolutionized target identification in drug discovery. However, such screens generate expansive and unrelated lists necessitating costly time-consuming validation. To address this challenge, we propose a dual-filter strategy that integrates literature-mined targets with CRISPR/Cas9 outputs, prioritizing pre-validated candidates literature to minimize lab validation burden. validate...
In recent years, studies have shown that lncRNA plays an essential regulatory role in biological life activities. disease and cancer research, the function of is closely related to inflammatory response, tumor formation cellular metabolism. Breast one most common malignant tumors women. The research on pathogenesis breast focus current research. Although mechanisms some lncRNAs been proven, complexity regulation has led incomplete research.The expression LOXL1-AS1 miR-143-3p was measured...
Cancer patients suffer from the toxicity of chemotherapy. Antidote, given as a remedy limiting poison, is an effective way to counteract toxicity. However, few antidotes abrogate chemotoxicity without compromising therapeutic efficacy. Herein, rationally designed nanoantidote can neutralize chemo-agents in normal cells but not enter tumors and thus would interfere with efficacy tumor treatment. The nanoantidote, consisting dendrimer core wrapped by reductive cysteine, captures Temozolomide...
Plasminogen activator, tissue type (PLAT) and its inhibitor serpin family E member 1 (SERPINE1) cooperatively regulate PLAT activity in various reproductive processes. However, it is unknown whether this includes bovine oocyte maturation. We addressed question the present study by evaluating SERPINE1 protein localization immature cumulus-oocyte complexes (COCs), as well mRNA expression cultured COCs after 0, 8, 16, 24 h of vitro maturation (IVM). also examined effects on germinal vesicle...
Chemotherapy-induced liver injury (CILI) is a pressing concern in cancer patients. One promising approach involves activating nuclear factor erythroid 2-related 2 (Nrf2) to mitigate CILI. However, selectively Nrf2 without compromising chemotherapy's efficacy has remained elusive. Herein, two RNAi delivery strategies were explored: lipid nanoparticle (LNP) and N-acetylgalactosamine (GalNAc) systems loaded with siRNA designed silence Kelch-like-ECH associated protein 1 (Keap1) by aiming for...
Hand-foot syndrome (HFS) is a widely recognized dose-limiting cutaneous toxicity effect of fluoropyrimidine chemotherapy agents that impairs clinical benefits and treatment outcomes. Even though the cause pathophysiology HFS are relatively reported, how translates into persistent inflammation has not been studied. Additionally, prevention strategies for based on its mechanistic occurrence development scarce. In our study, we demonstrated cGAS-STING signaling pathway-mediated cellular...
Although urokinase-type plasminogen activator (PLAU) and receptor (PLAUR) have been reported to play key roles in ovarian function, their precise contribution mammalian follicular development remains unclear. In this study, we first observed that PLAU PLAUR were present bovine granulosa cells (GCs). Following culture of with (0.5 ng/mL) antibody (10 µg/mL) separately together for 24 or 48 h, a proliferation assay showed interaction between contributes GC proliferation. To study the potential...
Gap junction channels in cumulus-oocyte complexes (COCs) enable the transmission and communication of small molecular signals between adjacent cells, such as cAMP. However, regulation gap function (GJF) by cAMP underlying mechanisms involved are not fully clarified. This study investigated effect on connexin 43 (CX43) expression GJF ovine COCs using immunofluorescence, quantitative real-time PCR (qRT-PCR), western blotting, detection. The CX43 was only found cumulus cells (CCs) side COC....
Chronic metabolic acidosis, arising as a complication of chronic kidney disease (CKD), not only reduces patients' quality life but also aggravates renal impairment. The available therapeutic modality, involving intravenous infusion NaHCO3 , engenders undesirable sodium retention, thereby increasing hemodynamic load and seriously exacerbating the primary disease. This deleterious cascade extends to development cardiovascular diseases. Herein, an orally administered, gut-restricted inorganic...
OBJECTIVE To investigate the effect and mechanism of a novel emodin derivative YX-18 on Burkitt lymphoma (BL) cells. METHODS MTT assay was used to detect proliferation BL cell lines CA46 Raji. Annexin V-PE/7-AAD double staining for detecting apoptosis Raji PI/RNase test cycle. JC-1 method measure changes mitochondrial membrane potential after treatment, DAPI morphology apoptotic Western blot analyze distribution NF-κB pathway protein (P65, P-P65, IκB, P-IκB) in cytoplasm nucleus, also...