A5041028607- Immune Response and Inflammation
- Cell Adhesion Molecules Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Immune cells in cancer
- Extracellular vesicles in disease
- PARP inhibition in cancer therapy
- Erythrocyte Function and Pathophysiology
- Phagocytosis and Immune Regulation
- Inflammatory mediators and NSAID effects
- Wound Healing and Treatments
- Neutropenia and Cancer Infections
- Medical and Biological Ozone Research
- DNA Repair Mechanisms
Northwestern University
2019-2021
Midwestern University
2019
Neutrophil (PMN) infiltration of the intestinal mucosa is a hallmark tissue injury associated with inflammatory bowel diseases (IBDs). The pathological effects PMNs are largely attributed to release soluble mediators and reactive oxygen species (ROS). We identified what we believe new, ROS-independent mechanism whereby activated tissue-infiltrating microparticles armed proinflammatory microRNAs (miR-23a miR-155). Using IBD clinical samples, in vitro vivo models, show that PMN-derived miR-23a...
Neutrophil (PMN) recruitment to sites of insult is critical for host defense, however excessive PMN activity and tissue accumulation can lead exacerbated inflammation injury. Myeloperoxidase (MPO) a azurophilic granule enzyme, which together with H 2 O , forms powerful antimicrobial system designed kill ingested bacteria. Intriguingly, in addition intracellular killing invading microorganisms extracellular damage due generation ROS, soluble MPO has been directly implicated modulating...
Neutrophil (PMN) infiltration of the intestinal mucosa is a hallmark tissue injury associated with inflammatory bowel diseases (IBD). The pathological effects PMNs are largely attributed to release soluble mediators and reactive oxygen species (ROS). We identified new, ROS‐independent mechanism, whereby activated, tissue‐infiltrating microparticles armed pro‐inflammatory microRNAs (miR‐23a miR‐155). Using IBD clinical samples, in vitro vivo models, we show that PMN‐derived miR‐23a/155...
Exacerbated Inflammation that can be driven by neutrophil (PMN) infiltration is one of the major risk factors for development and progression colorectal cancer (CRC). Using a biopsy‐based acute‐injury model, we previously showed miRNAs derived from PMN‐ m icro p articles (MPs) inhibit H omologous R ecombination (HR), leading to accumulation D ouble‐ S trand B reaks (DSBs). These observations led us investigate effects long‐term exposure intestinal epithelial cells HCT116 PMNs PMN‐MPs....