A5113054748- Extracellular vesicles in disease
- Heart Rate Variability and Autonomic Control
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Long-Term Effects of COVID-19
- Cardiac Valve Diseases and Treatments
- Infective Endocarditis Diagnosis and Management
- Cardiovascular Function and Risk Factors
- Advanced Nanomaterials in Catalysis
- Vagus Nerve Stimulation Research
- Augmented Reality Applications
- MicroRNA in disease regulation
- Smoking Behavior and Cessation
- Body Image and Dysmorphia Studies
- Diabetes Treatment and Management
- Virtual Reality Applications and Impacts
- Sexual function and dysfunction studies
- Streptococcal Infections and Treatments
- Nanoplatforms for cancer theranostics
- Pericarditis and Cardiac Tamponade
- Non-Invasive Vital Sign Monitoring
- Immune Response and Inflammation
- School Health and Nursing Education
- Circular RNAs in diseases
- Cardiovascular Disease and Adiposity
- Diverticular Disease and Complications
Baylor College of Medicine
2025
University of Minnesota Medical Center
2023-2024
University of Minnesota
2022-2023
Touro College
2020
Staten Island University Hospital
2020
Northwell Health
2020
Northwestern University
2017-2019
Neutrophil (PMN) infiltration of the intestinal mucosa is a hallmark tissue injury associated with inflammatory bowel diseases (IBDs). The pathological effects PMNs are largely attributed to release soluble mediators and reactive oxygen species (ROS). We identified what we believe new, ROS-independent mechanism whereby activated tissue-infiltrating microparticles armed proinflammatory microRNAs (miR-23a miR-155). Using IBD clinical samples, in vitro vivo models, show that PMN-derived miR-23a...
Atrial fibrillation/flutter (AF) is a major public health problem, associated with stroke, heart failure, dementia and death. It estimated that 20-30% of Americans will develop AF at some point in their lifetime. Current medications to prevent have limited efficacy significant adverse effects. Newer safer therapies are needed. Ventricular arrhythmias less prevalent than but may consequences including sudden cardiac death.Metformin the most prescribed, first-line medication for diabetes...
Severe aortic stenosis (AS) in bicuspid valves (BAV) is associated with an increased risk of paravalvular leak (PVL) after a transcatheter valve replacement (TAVR). Virtual reality (VR) has been shown to be effective tool surgical training, but its utility clinical practice not studied. Here we present the first study evaluate use VR simulation pre-procedure planning and prediction PVL TAVR patients severe BAV AS.
Purulent pericarditis (PP)- a purulent infection involving the pericardial space-requires high index of suspicion for diagnosis as it often lacks characteristic signs and carries mortality rate 40% even with treatment. Common risk factors include immunosuppression, diabetes mellitus, thoracic surgery, malignancy, uremia. Most reported cases PP occur in individuals predisposing factors, such result from more commonly observed preceding infections, pneumonia, osteomyelitis, meningitis. We...
Polymorphonuclear neutrophil-derived microparticles (PMN)-MPs) are lipid bilayer, spherical microvesicles with sizes ranging from 50–1,000 nm in diameter. MPs a newly evolving, important part of cell-to-cell communication and signaling machinery. Because their size the nature release, until recently MP existence was overlooked. However, improved technology analytical methods function health disease is now emerging. The protocols presented here aimed at isolating characterizing PMN-MPs by...
Polymorphonuclear neutrophil-derived microparticles (PMN)-MPs) are lipid bilayer, spherical microvesicles with sizes ranging from 50–1,000 nm in diameter. MPs a newly evolving, important part of cell-to-cell communication and signaling machinery. Because their size the nature release, until recently MP existence was overlooked. However, improved technology analytical methods function health disease is now emerging. The protocols presented here aimed at isolating characterizing PMN-MPs by...
Neutrophil (PMN) infiltration of the intestinal mucosa often leads to severe epithelial injury, however how this process occurs is unclear. The current work describes a novel mechanism, whereby membrane derived microparticles released by tissue infiltrating PMNs (PMN‐MPs) serve as shuttles protect and deliver active mediators locally modulate cellular function during inflammation. Specifically, myeloperoxidase (MPO), which abundantly expressed in PMN azurophilic granules used for microbial...
At any time, more than two-thirds of individuals who use tobacco want to quit.1United States Department Health and Human Services, Public Service Office the Surgeon GeneralSmoking Cessation: A Report General. General, 2020Google Scholar The health care system plays a key role in providing medications effectively connecting patients tobacco-dependence treatment (TDT). However, delivery TDT is highly variable clinical setting, even for with established lung diseases like COPD. Lack adequate...
Background: COVID-19 infections have been associated with cardiovascular autonomic dysfunction (AD). Clinical findings include fatigue, cognitive impairment, and postural intolerance. However, quantitative post-COVID AD assessments are lacking. Objective: Compare testing measures of post-COVID-19 subjects to controls those pure failure (PAF). Methods: Autonomic included 1) change in heart rate (HR) blood pressure (BP) active standing (AS) tilt table (TT), 2) time BP nadir recovery during AS...
Background: Cardiovascular (CV) autonomic dysfunction (AD) is a known potential complication following acute COVID-19 illness and may contribute to persistent symptoms, such as fatigue postural intolerance. However, the quantitative assessment of CV AD after an infection largely unexplored. Objective: Compare testing in patients presenting ‘early’ ‘late’ illness. Methods: was undertaken symptomatic (0-10 months) (11-20 Findings were compared results healthy control subjects. Measures...
Introduction: Atrial myopathy—defined as abnormal left atrial (LA) size and function— is associated with an increased risk of fibrillation, heart failure, dementia. Defining factors for myopathy important identifying preventative therapies. Objective: Examine the cross-sectional association central arterial stiffness LA function. Methods: We included 2,825 Atherosclerosis Risk in Communities (ARIC) study participants from Visit 5 (2011-2013) without coronary disease, sustained arrhythmias,...
Background: Hypertrophic cardiomyopathy (HCM) is a genetic heart disease, commonly associated with left ventricular outflow tract (LVOT) obstruction and mitral regurgitation (MR). Septal myectomy alcohol septal ablation are the current treatment options for LVOT MR in symptomatic patients who unresponsive to medical therapy. Recently, transcatheter edge-to-edge repair (TEER) of valve has been introduced as new therapeutic alternative these individuals, but there insufficient outcome data....
PMNs play key roles in host defense and tissue homeostasis, however, en‐masse infiltration by often leads to aberrant inflammation injury, is a hallmark of inflammatory bowel diseases (IBD). High numbers mucosa infiltrating have been correlated with the severity IBD, whereas IBD patients were found be at significantly higher risk developing colorectal cancer (CRC). While link between well established, little known about PMN contribution carcinogenesis. The accumulation DNA damage one leading...
Priapism is a disorder that occurs when the penis maintains prolonged erection in absence of appropriate stimulation. Conditions result hypercoagulable states and hyperviscosity are associated with ischemic priapism. COVID-19 increasingly coagulopathy. To date, there 6 reported cases priapism occurring patients COVID-19, 5 setting critical illness.We present case which we suspect resulted from COVID-19-associated coagulopathy patient without severe presentation.Although have been only...