A5029848945- Glaucoma and retinal disorders
- Hedgehog Signaling Pathway Studies
- Nonmelanoma Skin Cancer Studies
- Cancer and Skin Lesions
- Ocular Diseases and Behçet’s Syndrome
- Corneal surgery and disorders
- Axon Guidance and Neuronal Signaling
- Cerebral Venous Sinus Thrombosis
- Immunodeficiency and Autoimmune Disorders
- Parvovirus B19 Infection Studies
- Insects and Parasite Interactions
- Bacterial Infections and Vaccines
- Retinal and Optic Conditions
- Insect Utilization and Effects
- Multiple Sclerosis Research Studies
- Blood groups and transfusion
- Influenza Virus Research Studies
- Ocular Surface and Contact Lens
- Infectious Encephalopathies and Encephalitis
- Ophthalmology and Eye Disorders
- Traumatic Ocular and Foreign Body Injuries
- Ubiquitin and proteasome pathways
- Helminth infection and control
- Long-Term Effects of COVID-19
Centro Hospitalar de Lisboa Central
2020-2022
Purpose/Aim: Our study aims to evaluate corneal subbasal nerve plexus morphology by in vivo confocal microscopy (CCM) Multiple Sclerosis (MS) patients and explore its potential ability distinguish between MS healthy subjects.Materials methods: Cross-sectional study, including 60 22 subjects. Expanded Disability Status Scale (EDSS) was used assess neurological disability. All participants underwent full ophthalmology evaluation, CCM optical coherence tomography (OCT). Corneal fibre density...
The treatment of advanced periocular basal cell carcinomas becomes a challenge as surgery may involve highly mutilating procedures. Vismodegib is the first selective hedgehog inhibitor approved for locally tumors or metastatic disease.Analyze results with vismodegib in real-life setting reference center between 2014 and 2020.Retrospective longitudinal study. patient's demographic profile, comorbidities, tumor characteristics, outcomes were analyzed.A total 13 patients included. Median...
Iris melanocytoma (IM) is a rare variant of iris nevus with distinctive clinical and histopathological features. A 66-year-old woman, history right eye pigmented nevus, presented to us recent onset visual acuity decrease in that eye. She had melanocytic lesion iridocorneal angle invasion, peripheral corneal adhesion, pupil corectopia, sectorial cataract high intraocular pressure. Ultrasound biomicroscopy did not exclude malignant transformation, so excisional biopsy was performed revealing...
Horizontal gaze palsy and progressive scoliosis (HGPPS) is a rare autosomal recessive disorder caused by mutations in the ROBO3 gene. Clinical presentation consists of impairment conjugate horizontal eye movements together with beginning childhood. We report dizygotic twins HGPPS that had absence combined divergent strabismus synergistic divergence. One them also congenital palpebral ptosis vertical right eye. Onset occurred childhood rapid progression second decade life. Brain imaging...
Acute necrotising encephalopathy (ANE) is a rare disease that corresponds to rapidly progressive induced by viral infection. It frequently associated with mutation on the RAN-binding protein 2 ( RANBP2 ) gene–ANE1. We present case of 5-year-old boy clinical picture influenza aggravated an acute after 3rd day. Complementary examinations came back positive for A virus, and MRI showed aspects compatible ANE. He was treated accordingly subsequent improvement picture. During ambulatory follow-up,...
Abstract: Introduction: Blepharophimosis, ptosis and epicanthus inversus syndrome (BPES) is an uncommon autosomal dominant congenital disease caused by a mutation in the FOXL2 gene. Its major features are blepharophimosis, blepharoptosis, telecanthus, recently there have been some reports linking this to lacrimal gland (LG) agenesis. We studied LG changes BPES patients of our institution. Material methods: Six with ages between 1 39 years old were studied. Lacrimal film evaluation was...
Introduction: Nonpenetrating deep sclerectomy (NPDS) is one of the surgical procedures used for lowering intraocular pressure (IOP) in patients with uncontrolled open-angle glaucoma. This surgery can be enhanced use antimetabolites as well implants - devices that are placed to facilitate aqueous outflow by maintaining virtual space created after removing scleral flap. The purpose this study was report long-term efficacy and safety NPDS adjunctive mitomycin C (MMC) a nonabsorbable...