A5042722582- Fungal Biology and Applications
- Plant Molecular Biology Research
- Genomics and Rare Diseases
- Plant Reproductive Biology
- Genomics and Phylogenetic Studies
- HER2/EGFR in Cancer Research
- Machine Learning in Bioinformatics
- RNA and protein synthesis mechanisms
- Plant Gene Expression Analysis
- Melanoma and MAPK Pathways
- Protein Kinase Regulation and GTPase Signaling
- Mycorrhizal Fungi and Plant Interactions
- Genetic Neurodegenerative Diseases
University of Hong Kong
2021
Chinese University of Hong Kong
2018-2020
Abstract Insertions are one of the major types structural variations and defined as addition 50 nucleotides or more into a DNA sequence. Several methods exist to detect insertions from next-generation sequencing short read data, but they generally have low sensitivity. Our contribution is two-fold. First, we introduce INSurVeyor, fast, sensitive precise method that detects paired-end data. Using publicly available benchmark datasets (both human non-human), show INSurVeyor not only than any...
Coprinopsis cinerea is a model mushroom particularly suited for the study of fungal fruiting body development and evolution multicellularity in fungi. While microRNAs (miRNAs) have been extensively studied animals plants their essential roles post-transcriptional regulation gene expression, miRNAs fungi are less well characterized potential controlling remain unknown. To identify miRNA-like RNAs (milRNAs) C. explore expression patterns during early developmental transition development, small...
Significance Phosphoinositide 3-kinase activation typically occurs following stimulation by upstream receptor tyrosine kinases (RTKs), which alleviate p110α inhibition p85α. p85α and driver mutations have been reported to activate disrupting the inhibitory interface between p110α. This study revealed that in N-terminal SH2 domain can enhance activity inducing of multiple RTKs. Furthermore, combination treatment with RTK AKT inhibitors provides synergistic therapeutic efficacy. previously...
Abstract Coprinopsis cinerea is a model mushroom particularly suited to study fungal fruiting body development and the evolution of multicellularity in fungi. While microRNAs (miRNAs) are extensively studied animals plants for their essential roles post-transcriptional regulation gene expression, miRNAs fungi less well characterized potential controlling remain unknown. To identify miRNA-like RNAs (milRNAs) C. explore expression patterns during early developmental transition development,...