A5008536108- Blood groups and transfusion
- Vascular anomalies and interventions
- Platelet Disorders and Treatments
- Congenital Heart Disease Studies
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders Research
- Heparin-Induced Thrombocytopenia and Thrombosis
- Immunodeficiency and Autoimmune Disorders
- Coronary Artery Anomalies
- Cardiac Valve Diseases and Treatments
- Venous Thromboembolism Diagnosis and Management
- Parvovirus B19 Infection Studies
- Acupuncture Treatment Research Studies
- Myofascial pain diagnosis and treatment
- Elbow and Forearm Trauma Treatment
- Blood Coagulation and Thrombosis Mechanisms
- Shoulder Injury and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cardiovascular and exercise physiology
- Folate and B Vitamins Research
- Uterine Myomas and Treatments
- Central Venous Catheters and Hemodialysis
- Blood disorders and treatments
- Adenosine and Purinergic Signaling
- Cardiac Arrhythmias and Treatments
Children's Healthcare of Atlanta
2017-2024
Emory University
2017-2021
Aflac (United States)
2019-2021
Center for Drug Evaluation and Research
2021
United States Food and Drug Administration
2021
Center for Health, Exercise and Sport Sciences
2006
Background Heavy menstrual bleeding (HMB) is often the first symptom for female individuals with inherited disorders. Guidelines recommend performing hemostatic evaluation at HMB presentation. Von Willebrand factor (VWF) levels increase stress, making it unclear if VWF studies during acute are beneficial in diagnosing von disease (VWD). Objectives To determine utility of testing VWD HMB. Patients/Methods This retrospective cohort study evaluated presenting to emergency department (ED) from...
Background:In patients with mild type 1 von Willebrand disease (VWD), treatment guidelines suggest individualization of surgical management.However, these conditional recommendations are based on very low certainty evidence due to limited data outcomes in this population.Aim: Characterize procedural bleeding prophylaxis strategies and children VWD.Methods: This is a retrospective cohort study that included between 0-21 years age VWD (defined as VWF antigen and/or activity 30-50 IU/dL) who...
Background Thrombosis is common in infants undergoing staged surgeries for single‐ventricle congenital heart disease. The reported incidence and timing of thrombosis varies widely, making it difficult to understand the burden develop approaches prevention. We aimed determine cumulative following stage I Norwood procedure identify clinical characteristics associated with thrombosis. Methods Results analyzed data from Pediatric Heart Network Single Ventricle Reconstruction trial 2005 2009...
OBJECTIVES/SPECIFIC AIMS: Infants with single ventricle congenital heart disease (CHD) who undergo staged surgical reconstruction are among the pediatric patients at highest risk for thrombotic complications. Despite improvements in survival due to medical and advancements, complications common lead increased morbidity mortality, especially during first two stages of reconstruction. The burden caused by thrombosis is not fully known, factors associated clear. Due this knowledge gap,...
Purpose: Thromboembolic events are a common cause of increased morbidity and mortality in infants who undergo staged surgeries for single ventricle congenital heart disease (CHD). However, previously reported rates vary, from 1 to 46%, due limitations small sample size, retrospective study design, heterogeneity patient population, center experience. We used the public dataset PHN Single Ventricle Reconstruction (SVR) randomized clinical trial determine incidence, timing of, factors...
Exercise elicits a local augmentation in arterial distensibility, as characterised by decrease pulse wave velocity (PWV). This response may be attributed to changes vascular tone resulting from systemic net constrictor and dilator exercise. We sought further examine this relationship, with particular reference the muscle metaboreflex, isometric Seven healthy volunteers performed 2 minutes of ankle plantar-flexion at 40% MVC, conjunction either non-ischemic handgrip (HG, control condition) or...
Abstract Purpose T cell-Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (T cell-EBV-HLH) is prevalent in East Asia and has poor prognosis. Understanding of this disease limited literature regarding prevalence North America scarce. Herein, we summarize our experience. Methods A retrospective analysis cell-EBV-HLH patients admitted to Children's Healthcare Atlanta (GA, USA) from 2010-2020 was conducted. Additional immune studies were completed a subset patients. Results We...