A5058387338- Bladder and Urothelial Cancer Treatments
- Urinary and Genital Oncology Studies
- Prostate Cancer Treatment and Research
- Advanced Surface Polishing Techniques
- MicroRNA in disease regulation
- Connexins and lens biology
- Ubiquitin and proteasome pathways
- Diamond and Carbon-based Materials Research
- S100 Proteins and Annexins
- Cancer-related molecular mechanisms research
- RNA regulation and disease
- Virus-based gene therapy research
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Herpesvirus Infections and Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Molecular Biology Techniques and Applications
- Selenium in Biological Systems
- Immune Response and Inflammation
- Renal and related cancers
- Advanced Machining and Optimization Techniques
- DNA Repair Mechanisms
- Polymer Surface Interaction Studies
- Prostate Cancer Diagnosis and Treatment
- Renal cell carcinoma treatment
Chungbuk National University
2014-2019
Chungbuk National University Hospital
2017-2018
National University College
2014
New Generation University College
2014
Materials Science & Engineering
2010
Hanyang University
2009
MicroRNAs (miRNAs) in biological fluids are potential biomarkers for the diagnosis and assessment of urological diseases such as benign prostatic hyperplasia (BPH) prostate cancer (PCa). The aim study was to identify validate urinary cell-free miRNAs that can segregate patients with PCa from those BPH.In total, 1,052 urine, 150 serum, tissue samples or BPH were used study. A urine-based miRNA microarray analysis suggested presence differentially expressed PCa, these further validated three...
The most common symptom of bladder cancer (BC) is hematuria. However, not all patients with hematuria are diagnosed BC. Here, we explored a novel method to discriminate BC from under nonmalignant conditions by measuring differences in urinary cell-free microRNA (miRNA) expression between and those A multicenter study was performed using 543 urine samples obtained the National Biobank Korea, including 326 BC, 174 43 pyuria without cancer. miR-6124 miR-4511 ratio considerably higher than or...
The present study examined the utility of fibroblast growth factor receptor 3 (FGFR3) mutation status and gene expression as a prognostic marker in primary pT1 bladder cancer (BC). A total 120 patients with BC were enrolled. FGFR3 was determined by direct sequencing mRNA level reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis. results compared clinicopathological parameters, value evaluated Kaplan-Meier analysis multivariate Cox regression test. mutations...
We performed gene expression profiling in bladder cancer patients to identify cancer-specific survival-related genes muscle invasive (MIBC) patients. Sixty-two with MIBC were selected as the original cohort and another 118 chosen a validation cohort. The of USP18, DGCR2, ZNF699 measured we analyzed association between signatures survival. USP18 significantly correlated death (P=0.020, P=0.007, respectively). Cancer-specific survival low or DGCR2 group was longer than high (P=0.018, P=0.006,...
// Seok Joong Yun 1, 2, * , Seon-Kyu Kim 3, Jayoung 4, 5, 6 Eun-Jong Cha 7 Jang-Seong 8 Sun-Jin 9 Yun-Sok Ha 10 Ye-Hwan 1 Pildu Jeong Ho Won Kang 2 Jeong-Hwan 3 Jong-Lyul Park Young-Ki Choi 11 Sung-Kwon Moon 12 Yung-Hyun 13 Seon-Young 14 and Wun-Jae Department of Urology, Chungbuk National University College Medicine, Cheongju, Korea Hospital, Personalized Genomic Medicine Research Center, Institute Bioscience Biotechnology, Daejeon, 4 Surgery, Harvard Medical School, Boston, MA, USA 5...
Background: Cell division cycle 6 (CDC6) is an essential regulator of DNA replication and plays important roles in the activation maintenance checkpoint mechanisms cell cycle.CDC6 has been associated with oncogenic activities human cancers; however, clinical significance CDC6 prostate cancer (PCa) remains unclear.Therefore, we investigated whether mRNA expression level a diagnostic prognostic marker PCa. Methods:The study subjects included 121 PCa patients 66 age-matched benign prostatic...
Topoisomerase-II alpha (TopoIIA ), a DNA gyrase isoform that plays an important role in the cell cycle, is present normal tissues and various human cancers, can show altered expression both. The aim of current study was to examine value urinary TopoIIA cell-free as noninvasive diagnosis bladder cancer (BC).Two patient cohorts were examined. Cohort 1 (73 BC patients seven controls) provided tissue samples, whereas cohort 2 (83 patients, 54 nonmalignant hematuric 61 urine samples. Real-time...
Differentially expressed genes and their post-transcriptional regulator-microRNAs (miRNAs), are potential keys to pioneering cancer diagnosis treatment. The aim of this study was investigate how the miRNA-mRNA interactions might affect tumorigenesis bladder (BC) identify specific miRNA mRNA genetic markers in two BC types: non-muscle invasive (NMIBC) muscle (MIBC).We identified 227 that interacted with 54 miRNAs NMIBC, 14 10 MIBC. Based on data, we found extracellular matrix-related highly...
The anticancer effects of selenium may be mediated by selenium-binding proteins, such as SELENBP1. association between SELENBP1 expression levels and clinicopathologic parameters was assessed in renal cell carcinoma (RCC). mRNA measured with real-time quantitative polymerase chain reaction (qPCR) 139 specimens primary RCC 59 donor-matched normal-appearing kidney tissues. prognostic effect evaluated Kaplan–Meier multivariate Cox regression analyses. were significantly lower tumor tissues than...
Screening for genes or markers relevant to bladder cancer (BC) tumorigenesis and progression is of vital clinical significance. The present study used reverse-transcription quantitative PCR reaction assays examine the expression mRNA encoding Rho GTPase-activating protein 9 (ARHGAP9) in BC tissue samples determine whether ARHGAP9 an independent prognostic biomarker non-muscle invasive (NMIBC) muscle (MIBC). results revealed that downregulation patients with NMIBC MIBC was significantly...
This article has been corrected. See "Increased Expression of Herpes Virus-Encoded hsv1-miR-H18 and hsv2-miR-H9-5p in Cancer-Containing Prostate Tissue Compared to That Benign Hyperplasia Tissue" Volume 20 on page 374.
Mps one binder (MOB) proteins are integral components of signaling pathways that control important cellular processes, such as mitotic exit, centrosome duplication, apoptosis, and cell proliferation. However, the biochemical functions human MOB (hMOB) protein family remain largely unknown. The present study investigated association between hMOB3B expression clinicopathological characteristics prostate cancer (PCa).Study subjects included 137 PCa patients age-matched benign prostatic...
The interaction between polyacrylamide (PAM) and SiO2 film was investigated in order to elucidate the removal polycrystalline silicon (poly Si) selectivity poly isolation chemical mechanical planarization (CMP). hydrophilic characteristics of Si were analyzed by X-ray photoelectron spectroscopy (XPS) contact angle measurement. surface is more than that due siloxane (triple bond Si-O-Si triple bond) bonding. adsorption behavior PAM on determined isotherms force measurements using atomic...
Urinary Nucleic Acid TSPAN13-to-S100A9 Ratio as a Diagnostic Marker in Prostate CancerThe potential use of urinary nucleic acids diagnostic markers prostate cancer (PCa) was evaluated.Ninety-five urine samples and 234 tissue from patients with PCa benign prostatic hyperplasia (BPH) were analyzed.Micro-array analysis used to identify candidate genes, which verified by the two-gene expression ratio validated mRNA acid cohorts.Real-time quantitative polymerase chain reaction (qPCR) measure...
A ceria slurry, which is capable of high removal selectivity between silicon oxide and poly-Si, in the chemical mechanical planarization (CMP) process was investigated for construction poly-Si gates a multilevel cell (MLC) NAND flash memory below 51 nm. Anionic phosphate fluorosurfactant incorporated into slurry use as passivation agent to suppress removal. The with showed oxide-to-poly-Si (295:1), resulting from layers on due selective adsorption fluorosurfactant. behavior can be explained...