A5027902562- Virus-based gene therapy research
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Animal Virus Infections Studies
- Viral Infections and Immunology Research
- interferon and immune responses
- Parasitic Infections and Diagnostics
- Legionella and Acanthamoeba research
- Virology and Viral Diseases
- Reproductive tract infections research
- HIV/AIDS Research and Interventions
- Cytomegalovirus and herpesvirus research
- Amoebic Infections and Treatments
Chan Zuckerberg Initiative (United States)
2023-2025
University of Pennsylvania
2023
University of California, San Francisco
2023
Rochester Institute of Technology
2016-2020
Balamuthia mandrillaris is a free-living amoeba that can infect the central nervous system to cause granulomatous amebic encephalitis (GAE), highly fatal disease with mortality rates up 90%. GAE typically treated six-drug regimen limited efficacy and significant toxicity. Our lab previously identified nitroxoline, quinolone antibiotic, as promising therapeutic complement existing regimen, in 2021 nitroxoline was first successfully used treat human patient. In this study, we elucidate...
Decades of effort have yielded highly effective antiviral agents to treat HIV, but viral strains evolved resistance each inhibitor type, focusing attention on the importance developing new classes. A particularly promising target is HIV capsid, function which can be disrupted by potent inhibitors that persist long term in treated subjects. Studies with such contributed an evolving picture role capsid itself-the inhibitors, like certain protein (CA) amino acid substitutions, disrupt...
Human immunodeficiency virus (HIV) infection and the ensuing acquired syndrome (AIDS) disproportionally affect young women, yet understanding of factors promoting heterosexual transmission in female genital tract is limited. Colonization with highly diverse,