Treatment management for Major Depressive Disorder (MDD) has been challenging. However, electroencephalogram (EEG)-based predictions of antidepressant's treatment outcome may help during selection and ultimately improve the quality life MDD patients. In this study, a machine learning (ML) method involving pretreatment EEG data was proposed to perform such Selective Serotonin Reuptake Inhibitor (SSRIs). For purpose, acquisition experimental involved 34 patients 30 healthy controls....

Abstract Background Stress and burnout commonly threaten the mental health of medical students in Malaysia elsewhere. This study aimed to explore interrelations psychological distress, emotional intelligence, personality traits, academic stress, among students. Methods A cross-sectional was conducted with 241 Validated questionnaires were administered measure burnout, respectively. structural equation modelling analysis performed by AMOS. Results The results suggested a model good fit...

Abstract Background Coping denotes cognitive, emotional and behavioural struggles to tackle a troubled person-environment association. Therefore, coping strategies (CSs) are vital for mental well-being. Widespread research studies have explored this domain, targeting caregivers, nurses, physicians medical teachers, but limited has been done explore the common CSs utilised by students at undergraduate education level. we aimed identify frequently occurring their effects on health disorders...

Demanding profession has been associated with poor psychological health due to multiple factors such as overworking hours and night shifts. This study is determine prevalence of depression, anxiety stress among medical officers working at emergency department in Malaysian hospitals.A cross-sectional was conducted on 140 general hospitals from seven Malaysia regions. They were randomly selected their level measured by the 21-item Depression, Anxiety, Stress Scale.The highest (28.6%) followed...

The COVID-19 pandemic and the restrictions imposed that changed teaching learning activities may add a psychological impact to existing academic stress faced by university students. Past studies have associated low levels of disorder with high religiosity positive religious coping (RC). This study aimed determine level among students in Malaysia during measure their association An online cross-sectional survey was conducted between March June 2020 involving 450 instruments consisted...

The primarily rural and agrarian Kelantan province of Malaysia has high rates drug use is characterized by unique sociocultural factors. Combining qualitative ethnographic methods, we investigated treatment needs people who drugs (PWUD) in areas Kelantan. In February 2014, field visits, participant observation, focus group discussions (FGDs) with 27 active PWUD were conducted surrounding the capital city findings indicate a prevalence opiate amphetamine type stimulants (ATS) these areas. FGD...

Purpose: This study compared pain sensitivity among opioid dependent patients on methadone maintenance therapy (MMT) and naive subjects. Methods: The three hundred participants comprised 152 subjects 148 patients. Opioid had not taken any opioids including morphine to their best knowledge were presumed so after two consecutive negative urine screenings for drugs. All stabilized in treatment, defined as having been enrolled the program more than one month with no change of dosage over past...

Background: Methadone is a substrate of the permeability glycoprotein (P-gp) efflux transporter, which encoded by ABCB1 (MDR1) gene. Large interindividual variability in serum methadone levels for therapeutic response has been reported. Genetic variations gene may be responsible observed concentrations. Objective: This study investigated associations polymorphisms and concentration over 24-hour dosing interval opioid-dependent patients on maintenance therapy (MMT). Methods: One hundred...

Mental stress has been identified as a significant cause of several bodily disorders, such depression, hypertension, neural and cardiovascular abnormalities. Conventional assessment methods are highly subjective tedious tend to lack accuracy. Machine-learning (ML)-based computer-aided diagnosis systems can be used assess the mental state with reasonable accuracy, but they require offline processing feature extraction, rendering them unsuitable for real-time applications. This paper presents...

Clinical utility of Electroencephalography (EEG) based diagnostic studies is less clear for major depressive disorder (MDD). In this paper, a novel machine learning (ML) scheme was presented to discriminate the MDD patients and healthy controls. The proposed method inherently involved feature extraction, selection, classification validation. EEG data acquisition eyes closed (EC) open (EO) conditions. At extraction stage, de-trended fluctuation analysis (DFA) performed, on data, achieve...

Amphetamine-type stimulants (ATS) use is increasingly prevalent in Malaysia, including among individuals who also opioids. We evaluated cognitive functioning profiles with co-occurring opioid and ATS dependence their lifetime patterns of drug use. Participants (N = 50) enrolling a clinical trial buprenorphine/naloxone treatment or without atomoxetine completed the Raven's Standard Progressive Matrices, Rey-Osterrieth Complex Figure Test, Digit Span, Trail Making Symbol Substitution tasks....

Methadone is a full agonist of the opioid receptor mu 1 which encoded by OPRM1 gene. Sleep disorders were frequently reported opioid-dependent patients during methadone maintenance therapy (MMT). It possible, therefore, that genetic polymorphisms in influence sleep quality among on MMT. This study investigated association with The 165 male receiving MMT was evaluated using Pittsburgh Quality Index (PSQI). DNA extracted from whole blood and subjected to polymerase chain reaction (PCR)...

Methadone is a substrate of the P-glycoprotein efflux transporter, which encoded by ABCB1 (MDR1), and thus, polymorphisms may influence transport methadone at blood-brain barrier, affecting its adverse effects.This study investigated association between cold pressor pain responses among opioid-dependent patients on maintenance therapy (MMT).Malay male receiving MMT (n = 148) were recruited. Cold (pain threshold, tolerance, intensity) measured 0, 2, 4, 8, 12, 24 hours post-methadone dose. DNA...

We recently reported that a majority of opioid-dependent Malay males on methadone therapy are cold pain sensitive. It is postulated common OPRM1 polymorphisms may be responsible. This study investigated the association between 118A>G (dbSNP rs1799971) and IVS2+691G>C rs2075572) variants responses among maintenance therapy.Cold including threshold, tolerance, intensity were measured using pressor test. DNA was extracted from venous blood before polymerase chain reaction genotyping. Repeated...

Abstract Background : Stress and burnout commonly threaten the mental health of medical students in Malaysia elsewhere. This study aimed to explore interrelations psychological distress, emotional intelligence, personality traits, academic stress, among students. A cross-sectional was conducted with 241 Validated questionnaires were administered measure burnout, respectively. structural equation modelling analysis performed by AMOS. Results The results suggested a model good fit indices,...