A5103805162- Climate Change and Health Impacts
- Air Quality and Health Impacts
- Health disparities and outcomes
- Global Health Care Issues
- PI3K/AKT/mTOR signaling in cancer
- Flood Risk Assessment and Management
- Total Knee Arthroplasty Outcomes
- Hearing, Cochlea, Tinnitus, Genetics
- Energy and Environment Impacts
- Noise Effects and Management
- Chronic Lymphocytic Leukemia Research
- Radiopharmaceutical Chemistry and Applications
- Atmospheric chemistry and aerosols
- Prostate Cancer Treatment and Research
- Fire effects on ecosystems
- Climate variability and models
- Marine and fisheries research
- Venous Thromboembolism Diagnosis and Management
- Marine and coastal ecosystems
- Economic and Environmental Valuation
- HER2/EGFR in Cancer Research
- Disaster Management and Resilience
- Plant Pathogenic Bacteria Studies
- Coastal and Marine Management
- Estrogen and related hormone effects
Ambrx (United States)
2024
General Electric (United States)
2023
Abt Global (United States)
2015-2018
Schulman, Ronca & Bucuvalas
2015-2018
University of Minnesota Children's Hospital
2016-2018
Medical University of South Carolina
2013-2015
Stratton Park Engineering Company (United States)
2005-2014
Novartis (Switzerland)
2014
Sarah Cannon
2014
Suffolk University
2013
Linking knowledge with action for effective societal responses to persistent problems of unsustainability requires transformed, more open systems. Drawing on a broad range academic and practitioner experience, we outline vision the coordination organization systems that are better suited complex challenges sustainability than ones currently in place. This transformation includes inter alia: agenda setting, collective problem framing, plurality perspectives, integrative research processes,...
Cyanobacterial harmful algal blooms (CyanoHABs) have serious adverse effects on human and environmental health. Herein, we developed a modeling framework that predicts the effect of climate change cyanobacteria concentrations in large reservoirs contiguous U.S. The framework, which uses projections from five global circulation models, two greenhouse gas emission scenarios, cyanobacterial growth is unique coupling with hydrologic/water quality network model United States. Thus, it generates...
The health sector component of the first U.S. National Assessment, published in 2000, synthesized anticipated impacts climate variability and change for five categories outcomes: attributable to temperature, extreme weather events (e.g., storms floods) , air pollution, water- food-borne diseases, vector- rodent-borne diseases. Health Sector Assessment (HSA) concluded that are likely increase morbidity mortality risks several climate-sensitive outcomes, with net impact uncertain. objective...
Abstract Purpose: Phosphoinositide 3-kinase (PI3K)/AKT/mTOR pathway activation in patients with HER2-positive (HER2+) breast cancer has been implicated de novo and acquired trastuzumab resistance. The purpose of this study was to determine the clinical activity PI3K inhibitor buparlisib (BKM120) HER2+ advanced/metastatic resistant trastuzumab-based therapy. Experimental Design: In dose-escalation portion phase I/II study, trastuzumab-resistant locally advanced or metastatic were treated...
We use a physically-based water and energy balance model to simulate natural snow accumulation at 247 winter recreation locations across the continental United States. combine this with projections of snowmaking conditions determine downhill skiing, cross-country snowmobiling season lengths under baseline future climates, using data from five climate models two emissions scenarios. Projected are combined estimates activity, entrance fee information, potential changes in population monetize...
Abstract In temperate climates, mortality is higher in the winter than summer. Most wintertime deaths are attributed to cardiovascular and respiratory disease, with hypothermia from extreme cold accounting for a negligible share of all recorded deaths. International national assessments health risks climate change often conclude that increased temperatures will likely reduce mortality. This article examines support this hypothesis. We find although there physiological basis disease during...
<h3>Objectives</h3> To characterise the effects of noise exposure, including intermittent and peaky on hearing damage as assessed by standard pure-tone thresholds otoacoustic emissions, a longitudinal study was conducted newly hired construction apprentices controls over 10-year period. <h3>Methods</h3> Among 456 subjects recruited at baseline, 316 had least two (mean 4.6) examinations were included in this analysis. Annual threshold levels (HTLs) for air pure tones distortion product...
Abstract This study examines the impact of a changing climate on heat-related mortality in 40 large cities United States. A synoptic climatological procedure, spatial classification, is used to evaluate present climate–mortality relationships and project how potential changes might affect these values. Specifically, classification combined with downscaled future projections for decadal periods 2020–29, 2045–55, 2090–99 from coupled atmospheric–oceanic general circulation model. The results...
A warming climate will affect future temperature-attributable premature deaths. This analysis is the first to project these deaths at a near national scale for United States using city and month-specific temperature-mortality relationships. We used Poisson regressions model mortality as function of daily average temperature in 209 U.S. cities by month. data group into clusters applied an Empirical Bayes adjustment improve stability calculate cluster-based functions. Using from two models, we...
Abstract. A growing body of work suggests that the extreme weather events drive inland flooding are likely to increase in frequency and magnitude a warming climate, thus potentially increasing flood damages future. We use hydrologic projections based on Coupled Model Intercomparison Project Phase 5 (CMIP5) estimate changes modeled 1 % annual exceedance probability (1 AEP, or 100-year) at 57 116 stream reaches across contiguous United States (CONUS). link these database assets within mapped...
Total joint arthroplasty is one of the most successful orthopaedic surgical procedures. However, it carries a risk perioperative mortality. The purpose this study was to determine mortality rate for patients undergoing primary total knee in private-practice setting involving surgeon nonteaching institution.We analyzed 3048 consecutive arthroplasties, performed between July 1976 and December 1996, with respect data (deaths that occurred intraoperatively, during hospitalization, within ninety...
The inositol phosphatases phosphatase and tensin homologue (PTEN) Src homology 2 domain–containing (SHIP) negatively regulate phosphatidylinositol-3-kinase (PI3K)–mediated growth, survival, proliferation of hematopoietic cells. Although deletion PTEN in mouse T cells results lethal cell lymphomas, we find that animals lacking or SHIP B show no evidence malignancy. However, concomitant (bPTEN/SHIP−/−) spontaneous mature neoplasms consistent with marginal zone lymphoma or, less frequently,...
This paper applies city-specific mortality relationships for extremely hot and cold temperatures 33 Metropolitan Statistical Areas in the United States to develop projections historical potential future climates. These projections, which cover roughly 100 million of 310 U.S. residents 2010, highlight a change health risks from uncontrolled climate benefits greenhouse gas (GHG) mitigation policy. Our analysis reveals that projected days combined increases significantly over 21st century...
Background: While various policies have been implemented globally to mitigate climate change and reduce exposure toxic air pollutants, policy assessments considered few if any of the benefits children. Objective: To comprehensively assess co-benefits mitigation children, we expanded suite adverse health outcomes in U.S. Environmental Protection Agency’s Benefits Mapping Analysis Program (BenMAP) include additional associated with prenatal childhood ambient fine particulate matter (PM2.5). We...
The need to identify and try prevent adverse health impacts of climate change has risen the forefront policy debates become a top priority public community. Given observed projected changes in weather patterns, their current anticipated impacts, significant degree regulatory discussion underway U.S. government, it is reasonable determine extent federal investment research understand, avoid, prepare for, respond human United States.In this commentary we summarize risks States examine funding...
Europe experienced an unprecedented excessive heat event (EHE) in 2003, raising the question: What if a similar EHE were U.S. cities? This study used airmass-based meteorological method to develop analogs 2003 European for five cities: Detroit, New York, Philadelphia, St. Louis, and Washington, D.C.; calculated potential excess mortality these analogs. Analogs capture EHEs characteristics by determining daily deviations from long-term averages variables Paris, France, expressed as multiple...
Objective: The goal of this study was to assess the effect high-fidelity simulation (HFS) pediatric resuscitation training on resident performance and self-reported experience compared with historical controls. Methods: In case-control study, residents at a tertiary academic children’s hospital participated in 16-hour HFS curriculum. Primary outcome measures included cognitive knowledge, procedural proficiency, retention, comfort experience. intervention group matched-pair Results: Forty-one...
This paper develops and applies methods to quantify monetize projected impacts on terrestrial ecosystem carbon storage areas burned by wildfires in the contiguous United States under scenarios with without global greenhouse gas mitigation. The MC1 dynamic vegetation model is used develop physical impact projections using three climate models that project a range of future conditions. We also investigate sensitivity climates different initial conditions model. Our analysis reveals mitigation,...