A5019197680- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Blood disorders and treatments
- Cell Adhesion Molecules Research
- Immune Response and Inflammation
- Exercise and Physiological Responses
- Immunodeficiency and Autoimmune Disorders
- Immune responses and vaccinations
- Neuroinflammation and Neurodegeneration Mechanisms
- S100 Proteins and Annexins
- Immune cells in cancer
- Muscle metabolism and nutrition
- Legionella and Acanthamoeba research
- Diabetic Foot Ulcer Assessment and Management
- Sports Performance and Training
- Sepsis Diagnosis and Treatment
- Dialysis and Renal Disease Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Antifungal resistance and susceptibility
- Mast cells and histamine
- Eosinophilic Disorders and Syndromes
- Infections and bacterial resistance
- Prostate Cancer Treatment and Research
- Platelet Disorders and Treatments
- Acute Kidney Injury Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
Tel Aviv University
2004-2024
Meir Medical Center
2010-2024
Meyer Children's Hospital
2014
Amsterdam UMC Location University of Amsterdam
2004
Sanquin
2004
Assaf Harofeh Medical Center
2004
University of Amsterdam
2004
Wingate Institute
1995
Neutrophils are the predominant phagocytes that provide protection against bacterial and fungal infections. Genetically determined neutrophil disorders confer a predisposition to severe infections reveal novel mechanisms control vesicular trafficking, hematopoiesis, innate immunity.We clinically evaluated seven children from five families who had neutropenia, dysfunction, bone marrow fibrosis, nephromegaly. To identify causative gene, we performed homozygosity mapping using single-nucleotide...
Chronic granulomatous disease (CGD) is an innate immunodeficiency with a genetic defect of the nicotinamide adenosine dinucleotide phosphate, reduced, oxidase components. This leads to decreased reactive oxygen species (ROS) production, which renders patients susceptible life-threatening infections. Over course 30 years, we diagnosed CGD in 84 from 61 families using functional, molecular, and studies. The incidence Israel 1.05 per 100,000 live-births Jewish population 1.49 Israeli Arab...
Abstract Leucocyte adhesion deficiency (LAD) is a rare, innate autosomal recessive immunodeficiency with three subtypes. Twenty‐nine patients LADs were diagnosed and treated in Israeli Medical Centers the Palestinian Authority. We discuss phenotypic, genotypic biochemical features of LAD‐I, LAD‐II LAD‐III during neonatal period early infancy 18, 6 5 patients, respectively. Consanguinity was frequent. Common severe infections variable aetiology, excessive leukocytosis delayed umbilical cord...
Object. The aim of this prospective study was to evaluate the phagocytic, humoral, and cellular arms immune system in comatose patients shortly after severe brain injury compare findings with those reported earlier a persistent vegetative state. conducted intensive care units immunology laboratories university-affiliated hospitals central Israel. Methods. group consisted 14 men aged 16 65 years who were as result acute due mechanical trauma. All studied within 72 hours injury. Brain damage...
Mast cells have recently been shown to control neutrophil recruitment during T-cell mediated cutaneous DTH reaction in vivo through TNF-alpha and MIP-2, the functional murine analogue of human IL-8. Although nature signals transmitted from T which activate mast has not yet defined, we hypothesized that a direct cross-talk (i.e. heterotypic adhesion) between these two cell populations exists, as previously reported.The present study was aimed at gaining insight into role cell-T contact...
The T cell receptor (TCR) signaling pathway is an ensemble of numerous proteins that are crucial for adequate immune response. Disruption any protein involved in this leads to severe immunodeficiency and unfavorable clinical outcomes. Here, we describe infant with who was found have novel biallelic mutations SLP76. SLP76 a key TCR other hematopoietic pathways. Previous studies were performed using Jurkat-derived human leukemic lines SLP76-deficient mice. Our current study links gene, the...
Recent studies reported reduced immunity in athletes following exercise. Physical activity affects both cellular and humoral immune functions. Scant information exists on exercise-induced changes the system among children. The purpose of present study was to investigate effect aerobic exercise several aspects functions 10-12 year-old highly trained female gymnasts (n = 7) untrained girls 6). All were pre-pubertal. Venous blood samples drawn before, immediately after 24 h 20 min treadmill...
Neutropenia, which may develop as a consequence of chemotherapy, increases the risk bacterial infection. Similarly, increased infection appears in disorders phagocytic functions, such genetic disorder chronic granulomatous disease. To elucidate organizing principles behind these distinct immunodeficiency conditions, we investigated interaction between vitro bacteria and human neutrophils by experiments mathematical modeling. The model showed that dynamics exhibit bistability for certain...
Objectives —Recent studies have indicated reduced immunity in trained athletes. Aim —To assess the effects of aerobic and anaerobic exercise on phagocytic process 18–26 year old female judoka (n = 8) untrained controls 7). Methods —Each subject participated randomly two different testing sessions (aerobic, 20 minutes treadmill running at 70–80% maximal heart rate; anaerobic, Wingate test). Venous blood samples were drawn before, immediately after, 24 hours after each session. Results —There...
Recent studies have reported reduced immunity in trained athletes. Scant information exists on changes the immune function among children. The purpose of this study was to assess effect aerobic exercise phagocytic process neutrophils and complement system young Subjects included prepubertal elite female gymnasts ( n =7) untrained girls =6) aged 10–12 years. Venous blood withdrawn before, immediately post 24 h following a 20‐min run at heart rate 170–180 beats · min −1 . Neutrophil random...
Intense exercise bouts are associated with a reduction of immune function and increased susceptibility to infections. Neutrophils act as first line defense eliminate infectious agents also involved in muscle tissue inflammatory response exercise. Intensive suppresses several neutrophil functions including chemotaxis. The study investigates the pathophysiological mechanisms impaired chemotaxis after submaximal aerobic exercise.Twenty-three healthy physically active adult males were tested...
Neutrophil dysfunction among newborn infants, especially those born prematurely, is well recognized, but the mechanism responsible for this phenomenon yet to be clarified.In study, we evaluated stimulus response coupling in neutrophils from 90 healthy newborns and 96 adults an effort establish whether defective neonatal neutrophil function a result of impaired signal perception or immature responsiveness.Measurement rapid-and slow-light scattering responses (LSR) 1 µM FMLP stimulation...
Abstract We report for the first time a child with chronic granulomatous disease (CGD) who developed acute lymphoblastic leukemia (ALL). The diagnosis of CGD was made at age 4 months, by studies his neutrophil functions. superoxide production cells negligible, as bactericidal activity. He found to have deficiency gp91 phox subunit leukocyte NADPH oxidase, X‐linked inheritance disease. DNA analysis revealed C nucleotide insertion between C1028 and T1029. This has not been described before...
Background Leukocyte adhesion deficiency 1 (LAD1) is an inherited disorder of neutrophil function. Nonsense mutations in the affected CD18 (ITB2) gene have rarely been described. In other genes containing such mutations, treatments with aminoglycoside types antibiotics (e.g., gentamicin) were reported to partially correct premature protein termination, by induction readthrough mechanism. Methodology/Principal Findings Genetic analysis was performed on 2 LAD1 patients. Expression, functional...
Summary Modern era advancements in medical care, with improved treatment of infections, can result delayed diagnosis congenital immunodeficiencies. In this study we present a retrospective cohort 16 patients diagnosed Chronic Granulomatous Disease (CGD) at adulthood. Some the had milder clinical phenotype, but others classic phenotype severe infectious and inflammatory complications reflecting profoundly impaired neutrophil function. It is therefore great importance to investigate individual...