A5103268252- Systemic Lupus Erythematosus Research
- Renal Diseases and Glomerulopathies
- Peripheral Neuropathies and Disorders
- Drug-Induced Ocular Toxicity
- Complement system in diseases
- Vasculitis and related conditions
- Atherosclerosis and Cardiovascular Diseases
- Nerve injury and regeneration
- Inflammatory Myopathies and Dermatomyositis
- Genetic Associations and Epidemiology
- Bone health and treatments
- Lysosomal Storage Disorders Research
- Osteoarthritis Treatment and Mechanisms
- Advanced Biosensing Techniques and Applications
- Signaling Pathways in Disease
- Growth Hormone and Insulin-like Growth Factors
- Advanced Proteomics Techniques and Applications
- Blood disorders and treatments
- Lung Cancer Treatments and Mutations
- Nuclear Receptors and Signaling
- Cellular transport and secretion
- Dermatological and COVID-19 studies
- Biochemical Acid Research Studies
- Diabetes and associated disorders
- Liver Disease Diagnosis and Treatment
Montefiore Medical Center
2019-2025
Albert Einstein College of Medicine
2019-2025
Weatherford College
2024
Hackensack University Medical Center
2024
Jacobi Medical Center
2024
University of Alabama at Birmingham
2024
Tsinghua University
2019-2024
Center for Life Sciences
2024
Peking University
2024
Chinese Institute for Brain Research
2019-2020
Repeated failures of "Aβ-lowering" therapies call for new targets and therapeutic approaches Alzheimer's disease (AD).We propose to treat AD by halting neuronal death repairing synapses using a BDNF-based therapy.To overcome the poor druggability BDNF, we have developed an agonistic antibody AS86 mimic function evaluate its potential AD.Method: Biochemical, electrophysiological behavioral techniques were used investigate effects in vitro vivo.Results: specifically activated BDNF receptor...
Introduction: Fat-free mass (FFM) is a critical component of the human body, with implications for various diseases. Methods:We conducted comprehensive analysis integrating phenome-wide association study (PheWAS), two-sample Mendelian randomization (MR) analysis, and systematic review to investigate associations between FFM health outcomes. Results: PheWAS identified 183 phenotypes enriched associations, including diseases, body composition, lifestyle factors. Two-sample MR using FinnGen UK...
Lupus nephritis (LN) is one of the most severe manifestations systemic lupus erythematosus (SLE). Interstitial fibrosis/tubular atrophy (IFTA) on kidney biopsies strongly predicts progression to end-stage renal disease although factors associated with IFTA remained unknown. This study aimed evaluate demographic, clinical, and histopathological at time index that are worsening repeat identify potential biomarkers interstitial damage. Patients LN Class I V or mixed who underwent a clinically...
While Brain-derived Neurotrophic Factor (BDNF) has long been implicated in treating neurological diseases, recombinant BDNF protein failed multiple clinical trials. In addition to its unstable and adhesive nature, can activate p75NTR, a receptor mediating cellular functions opposite those of TrkB. We have now identified TrkB agonistic antibodies (TrkB-agoAbs) with several properties superior BDNF: They exhibit blood half-life days instead hours, diffuse centimeters neural tissues...
The complement system, an important part of the innate is known to play a central role in many immune mediated kidney diseases. All parts system including classical, alternative, and mannose-binding lectin pathways have been implicated complement-mediated injury. Although components are thought be mainly synthesized liver activated circulation, emerging data suggest that inside leading direct Urinary biomarkers likely better reflection inflammation within kidneys as compared traditional...
Introduction Treatment failures for lupus nephritis (LN) are high with 10%–30% of patients progressing to end-stage renal disease (ESRD) within 10 years. Interstitial fibrosis/tubular atrophy (IFTA) is a predictor progression ESRD. Prior studies suggest that tubulointerstitial injury secondary proteinuria in LN mediated by complement activation the tubules, specifically through membrane attack complex (MAC). This study aimed investigate associations between tubular MAC deposition IFTA and...
Background and objectives Lupus nephritis remains a common cause of morbidity mortality in systemic lupus erythematosus (SLE). Current guidelines recommend performing kidney biopsy at urine protein-creatinine ratio ≥0.5 g/g. However, cross-sectional studies reported high prevalence active histologic lesions, even chronic irreversible scarring, patients with low-grade proteinuria. This study was initiated to assess disease progression SLE proteinuria identify risk factors for overt suggestive...
To examine the relationships between radiographic knee osteoarthritis (RKOA), symptomatic (sRKOA), and chondrocalcinosis, as outcome variables, autoimmune thyroid disease (AITD) autoantibodies, anti-thyroid peroxidase antibody (TPOAb) anti-thyroglobulin (TgAb), in Third National Health Nutrition Examination Survey (NHANES III) data source.NHANES III provided on 2291 persons over age of 60 years that included variables interest RKOA, sRKOA autoantibodies TPOAb TgAb. A log-binomial regression...
Abstract Background Lupus nephritis (LN) is one of the most severe manifestations systemic lupus erythematosus (SLE). Interstitial fibrosis/tubular atrophy (IFTA) on kidney biopsies strongly predicts progression to end-stage renal disease. However, factors associated with IFTA are not known. The objective this study was evaluate demographic, clinical, and histopathological at time index that worsening repeat biopsies. Methods Patients LN Class I V or mixed who underwent a clinically...
Abstract Background SLE manifestations after ESRD may be underdiagnosed and undertreated, contributing to increased morbidity mortality. Whether specific symptoms persist or a shift towards new occurs has not been extensively studied, especially in the non-Caucasian patients United States. In addition, hydroxychloroquine (HCQ) prescribing patterns post-ESRD have described. The objective of this study was assess lupus activity HCQ before development. Knowledge gained from aid identification...
End-stage kidney disease (ESKD) from lupus nephritis (LN) is a major cause of morbidity and mortality in patients with systemic erythematosus (SLE). Kidney biopsy the gold standard for diagnosis prognostication LN. While interstitial fibrosis tubular atrophy (IFTA) predict progression to ESKD, National Institutes Health (NIH) classification inflammation unscarred cortical parenchyma not predictive chronic (CKD) progression. The objective this study was determine whether total that accounts...
A 46-year-old Hispanic man presented with fever, genital ulcers, left eye redness and chest pain. Physical examination was notable for a healed oral ulcer scrotal bilateral superficial thrombophlebitis. He found to have new-onset pancytopenia. CT of the showed pericardial pleural effusions rapidly progressing inflammation aortic arch ascending vessels. Although patient had Behcet’s disease (BD)-like symptoms, pancytopenia could not be explained by diagnosis, prompting bone marrow biopsy...
Antineutrophilic cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a condition characterized by vessel inflammation and may have variety of etiologies. Among these, cocaine its common adulterant, levamisole, been described to contribute the development AAV with distinct cutaneous manifestations. Classically, these manifestations involve purpuric or necrotic lesions involving ears, nose, extremities. However, we present case cocaine-induced presenting violaceous nodules on dorsal...
<h3>Background:</h3> Hydroxychloroquine (HCQ) use in SLE has been associated with a lower risk of end-organ damage, flares, and thrombosis, potential mortality benefit among end stage renal disease (ESRD)<sup>1, 2, 3</sup>. However, fewer than 30% continue HCQ after ESRD onset<sup>3</sup>. On the other hand, there is an increased toxicity SLE-ESRD<sup>4</sup>. It not studied what factors are ESRD. Understanding these may inform future studies assessing safety efficacy SLE-ESRD address...
Objective To determine whether hydroxychloroquine (HCQ) dose is associated with adverse cardiac outcomes in patients systemic lupus erythematosus (SLE). Methods Patients SLE taking HCQ and ≥1 echocardiogram followed at a tertiary care center the Bronx, New York between 2005 2021 were included. The weight‐based start date was main exposure of interest. outcome incident all‐cause heart failure reduced ejection fraction (HFrEF), life‐threatening arrhythmia, or death. We used Fine‐Gray...
Background: Intrarenal complement activation has been implicated in the pathogenesis of tubulointerstitial fibrosis lupus nephritis (LN) based on prior animal studies. The assembly membrane attack complex (MAC) by C5b to C9 cell leads cytotoxic pores and lysis, while CD59 inhibits MAC formation preventing from joining complex. We hypothesize that imbalance between inhibition, as defined increased production individual components uncontrolled relative are associated with interstitial tubular...