A5053980571- Nuclear Receptors and Signaling
- Viral Infectious Diseases and Gene Expression in Insects
- Cholinesterase and Neurodegenerative Diseases
- Biochemical and Structural Characterization
- Alzheimer's disease research and treatments
- Monoclonal and Polyclonal Antibodies Research
- Bacterial Genetics and Biotechnology
- Genomics and Phylogenetic Studies
- RNA and protein synthesis mechanisms
Gakushuin University
2019-2022
Alzheimer’s disease pathology is characterized by extracellular deposits of amyloid-β (Aβ) and intracellular inclusions hyperphosphorylated tau. Although genetic studies familial suggest a causal link between Aβ symptoms, the failure various Aβ-targeted strategies to slow or halt progression has led consideration idea that inhibition tau aggregation might be more promising therapeutic approach. Methylene blue (MB), which inhibits rescue memory deficits in mouse model tauopathy, however,...
Proteinaceous protease inhibitors can strongly and specifically inhibit cognate proteases, but their use as pharmaceuticals is limited by size. As such, the development of effective peptide would be beneficial for biochemical studies drug discovery. In this study, we applied a phage display system to select subtilisin BPN'-binding peptides evaluated inhibitory activities against BPN'. A 12mer with an intramolecular disulfide bond inhibited BPN' (Ki value 13.0 nm). Further mutational analyses...