A5102804560- Catalytic Alkyne Reactions
- Organic Chemistry Cycloaddition Reactions
- Cyclopropane Reaction Mechanisms
- Asymmetric Synthesis and Catalysis
- Catalytic C–H Functionalization Methods
- Synthesis and Catalytic Reactions
- Crystallization and Solubility Studies
- Traditional and Medicinal Uses of Annonaceae
- X-ray Diffraction in Crystallography
Aarhus University
2023-2024
Chiral eight-membered carbocycles are important motifs in organic chemistry, natural product chemical biology, and medicinal chemistry. The lack of synthetic methods toward their construction is a challenge preventing rational design stereoselective synthesis. catalytic enantioselective [4 + 4] cycloaddition one the most straightforward atom-economical to obtain chiral cyclooctadiene derivatives. We report first organocatalytic asymmetric 9H-fluorene-1-carbaldehydes with electron-deficient...
Abstract The substituted tetrahydrofuran core is a structural motif in many biologically active and natural compounds. However, the scarcity of enantioselective methods developed towards its synthesis makes this field challenging attractive to explore. Herein, first Brønsted‐base catalyzed (3+2) annulation donor‐acceptor cyclopropanes with aldehydes ketones affording enantioenriched 2,3,5‐substituted tetrahydrofurans reported. reaction concept based on activation racemic β‐cyclopropyl by...
Abstract The substituted tetrahydrofuran core is a structural motif in many biologically active and natural compounds. However, the scarcity of enantioselective methods developed towards its synthesis makes this field challenging attractive to explore. Herein, first Brønsted‐base catalyzed (3+2) annulation donor‐acceptor cyclopropanes with aldehydes ketones affording enantioenriched 2,3,5‐substituted tetrahydrofurans reported. reaction concept based on activation racemic β‐cyclopropyl by...
A mechanistic investigation into the novel combination of
Abstract A novel strategy that combines oxidative aminocatalysis and gold catalysis allows the preparation of chiral α‐quaternary isochromanes, a motif is prevalent in natural products synthetic bioactive compounds. In first step, α‐branched aldehydes propargylic alcohols are transformed into ethers with excellent optical purities (>90 % ee ) via umpolung DDQ an amino acid‐derived primary amine catalyst. Subsequent gold(I)‐catalyzed intramolecular hydroarylation affords isochromane...