A5074191838- Angiogenesis and VEGF in Cancer
- Pluripotent Stem Cells Research
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Adipose Tissue and Metabolism
- Single-cell and spatial transcriptomics
- Congenital heart defects research
- SARS-CoV-2 and COVID-19 Research
- CRISPR and Genetic Engineering
- Cancer Cells and Metastasis
- Ultrasound in Clinical Applications
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Mitochondrial Function and Pathology
- Vaccine Coverage and Hesitancy
- Radiology practices and education
- Virology and Viral Diseases
- Mechanisms of cancer metastasis
- Coronary Interventions and Diagnostics
- Cardiovascular Function and Risk Factors
- Cancer, Hypoxia, and Metabolism
- Abdominal Trauma and Injuries
- Nuclear Receptors and Signaling
- Cell Adhesion Molecules Research
Queen's University Belfast
2020-2025
University of Toronto
2023
St. George's University
2023
University of Waterloo
2023
Vascular endothelial cell (EC) dysfunction plays a key role in diabetic complications. This study discovers significant upregulation of Quaking-7 (QKI-7) iPS cell-derived ECs when exposed to hyperglycemia, and human iPS-ECs from patients. QKI-7 is also highly expressed coronary arterial donors, on blood vessels critical limb ischemia patients undergoing lower-limb amputation. expression tightly controlled by RNA splicing factors CUG-BP hnRNPM through direct binding. correlated with disrupted...
The growing prevalence of diabetes highlights the urgent need to study diabetic cardiovascular complications, specifically cardiomyopathy, which is a diabetes-induced myocardial dysfunction independent hypertension or coronary artery disease. This review examines role mitochondrial in promoting cardiac and metabolic mechanisms such as hyperglycaemia-induced oxidative stress. Chronic hyperglycaemia insulin resistance can activate harmful pathways, including advanced glycation end-products...
Abstract Vascular organoids (VOs), derived from induced pluripotent stem cells (iPSCs), hold promise as in vitro disease models and drug screening platforms. However, their ability to faithfully recapitulate human vascular cellular composition remains unclear. In this study, we demonstrate that VOs iPSCs of donors with diabetes (DB-VOs) exhibit impaired function compared non-diabetic (ND-VOs). DB-VOs display elevated levels reactive oxygen species (ROS), heightened mitochondrial content...
Introduction: Focused assessment with sonography for trauma (FAST) ultrasound (US) is a valuable medical examination used in settings, particularly rapid responses to events such as natural disasters. Although the efficacy and benefits of FAST patient care have been extensively studied, there limited research on training students FAST. Previous studies found that can proficiently perform US after two days training. However, these exclusively included first-year without considering variations...
Abstract The presence of both endothelial cells (ECs) and mural are central to the proper function blood vessels in health pathological changes diseases including diabetes. Although iPSCs-derived vascular organoids (VOs) provide an appealing vitro disease model platform for drug screening, whether these recapitulate human remains debatable. Here, we show diabetic (DB)-VOs represent impaired enhanced ROS activity, with higher mitochondrial content increased pro-inflammatory cytokines, less...
<h3>Introduction</h3> Impaired function of blood vessels can lead to cardiovascular diseases (CVDs), which is a major cause death worldwide. The presence both endothelial cells (ECs) and mural central the proper in health pathological changes including diabetes. Although iPSCs-derived vascular organoids (VOs) provide an appealing source for vitro disease modelling drug testing, whether these recapitulate human yet be determined. <h3>Methods</h3> Blood mononuclear from six donors with...
<h3>Introduction</h3> Diabetes and associated cardiovascular diseases (CVDs) are a class of disorders affecting the heart or blood vessels. Despite progress in clinical research therapy, CVDs still represent leading cause mortality morbidity worldwide. The hallmarks cardiac include dysfunction cardiomyocyte death, inflammation, fibrosis, scar tissue, hyperplasia, hypertrophy, abnormal ventricular remodelling. loss cardiomyocytes is an irreversible process that leads to fibrosis formation,...
<h3></h3> Diabetic endotheliopathy is the main cause for impaired angiogenesis and reduced neovascularization that lead to microvascular injury vascular complications. The pathogenic basis complications arising from diabetes complex. Elucidation of key underlying mechanisms will help development novel therapies discovery potential biomarkers. ability generate functional endothelial cells (ECs) induced pluripotent stem (iPSCs) small amounts blood a powerful tool cell-based therapies. Human...
The relationship between MMR vaccine and ASD to this day has been a big problem in the public eye. presumed causality of from led portion parents worldwide not vaccinate their children with vaccine. If there was correlation ASD, then should have rise cases more get vaccinated. To fully analyze connection vaccine, both case studies qualitative were accessed. Qualitative provided information regarding repercussions under-vaccination over years, while used study any potential causal effects...