A5011327419- Lanthanide and Transition Metal Complexes
- Advanced MRI Techniques and Applications
- Radioactive element chemistry and processing
- Magnetism in coordination complexes
- Medical Imaging Techniques and Applications
- Glioma Diagnosis and Treatment
- MRI in cancer diagnosis
- X-ray Diffraction in Crystallography
- Radiomics and Machine Learning in Medical Imaging
- Cancer Research and Treatments
- Nanoplatforms for cancer theranostics
- Advanced NMR Techniques and Applications
- Electron Spin Resonance Studies
- Radiopharmaceutical Chemistry and Applications
- Meningioma and schwannoma management
- Ultrasound and Hyperthermia Applications
- Crystallization and Solubility Studies
Bracco (Italy)
2016-2025
University of Turin
2016
The purpose of this study was to compare Gd levels in rat tissues after cumulative exposure four commercially available macrocyclic gadolinium-based contrast agents (GBCAs).Sixty-five male Sprague-Dawley rats were randomized groups (n = 15 per group) and one control group 5). Animals each received 20 GBCA administrations (four week ProHance®, Dotarem®, Clariscan™, or Gadovist® for 5 consecutive weeks) at a dose 0.6 mmol/kg bodyweight. After 28-days' recovery, animals sacrificed harvested...
Abstract Magnetic Resonance Imaging (MRI) plays a vital role in the accurate diagnosis of numerous human diseases and disorders, with Gd(III)‐based contrast agents (GBCAs) being used ≈30%–40% procedures, resulting ≈30 million doses administered annually worldwide. The careful design rigid macrocyclic chelator featuring highly hydrophilic periphery leads to development gadopiclenol, first bis‐hydrated MRI agent, recently approved for clinical use by both FDA EMA. stereochemistry coordinating...
The relaxivity of Gd(HP-DO3A) was studied as a function pH and buffer composition in order to identify the main factors observed relaxation enhancement due exchange coordinated hydroxyl proton. It established that paramagnetic time, T1M, proton is about 50% shorter than protons water molecule. control p K alcoholic -OH moiety ligand fundamental utilize enhanced under physio/pathologic conditions. A new derivative synthesized by replacing -CH3 group with -CF3 moiety. In this complex, becomes...
Purpose To dissect the contributions to longitudinal relaxivity (r 1 ) of two commercial contrast agents (CAs), Gd‐DOTA and Gd‐HP‐DO3A, synthesize/characterize a novel macrocyclic agent (Gd‐Phen‐DO3A) having superior r . Methods Longitudinal relaxation rates R CAs in saline with/without human serum albumin (HSA), ionized simulated body fluid (i‐SBF), viscous (v‐SBF), plasma were measured. Results have been interpreted evince main determinants observed values. In v‐SBF or presence HSA, is...
Objectives Artificial intelligence (AI) methods can be applied to enhance contrast in diagnostic images beyond that attainable with the standard doses of agents (CAs) normally used clinic, thus potentially increasing power and sensitivity. Deep learning–based AI relies on training data sets, which should sufficiently large diverse effectively adjust network parameters, avoid biases, enable generalization outcome. However, sets acquired at CA outside standard-of-care are not commonly...
The Gd<sup>III</sup> complex of Ph-HP-DO3A shows the highest contribution to relaxivity by intramolecular proton exchange –OH group.
The simple modification of the hydroxypropyl arm in Gd(HP-DO3A) complex allows to achieve an increased relaxivity by activation intramolecular catalysis proton exchange process.
Abstract Gd(III)‐complexes have been employed for more than twentyfive years as MRI contrast agents. In the last decade, considerations about potential toxicity of residual gadolinium in patients suffering from severe kidney diseases moved researchers to evaluate alternative solutions, among them Mn(II)‐complexes, shorten T 1 and achieve good image contrast. this article we report on synthesis a new Mn(II)‐chelate, endowed with deoxycholic acid residue designed interact reversibly serum...
Abstract A dinuclear gadolinium(III) chelate containing two moieties of diethylenetriaminepentaacetic acid (DTPA), covalently conjugated to an analogue deoxycholic acid, was synthesized and thoroughly characterized. full relaxometric analysis carried out, consisting 1) the acquisition nuclear magnetic resonance dispersion (NMRD) profiles in various media; 2) study binding affinity serum albumin; 3) measurement 17 O transverse relaxation rate versus temperature, 4) a transmetallation assay....
Abstract Meningioma in vivo research is hampered by the difficulty of establishing an easy and reproducible orthotopic model able to mimic characteristics a human meningioma. Moreover, leptomeningeal dissemination high mortality are often associated with such orthotopical models, making them useless for clinical translation studies. An optimized method inducing meningiomas nude mice at two different sites described this paper reproducibility low models demonstrated. Skull base were induced...
Breast cancer is the most common among women worldwide. For high-risk women, contrast enhanced (CE)-magnetic resonance imaging (MRI) recommended as supplemental screening together with mammography. The development of new MRI agents an active field research, which requires efficacy tests on appropriate preclinical pathological models. In this work, a refined method to orthotopically induce breast in BALB/c mice was developed using ultrasound (US) guide for precise localisation tumour...