A5033919515- Metabolism and Genetic Disorders
- Hemophilia Treatment and Research
- Neurofibromatosis and Schwannoma Cases
- Neonatal and fetal brain pathology
- Epilepsy research and treatment
- Platelet Disorders and Treatments
- Vascular Malformations Diagnosis and Treatment
- Meningioma and schwannoma management
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Complement system in diseases
- FinTech, Crowdfunding, Digital Finance
- Neuroblastoma Research and Treatments
- Hepatitis B Virus Studies
- Renal Diseases and Glomerulopathies
- Cervical Cancer and HPV Research
- Genetics and Neurodevelopmental Disorders
- Genital Health and Disease
- Management of metastatic bone disease
Banaras Hindu University
2023-2024
In this study, we have evaluated the underlying aetiologies, yield of genetic testing and long-term outcomes in patients with early-infantile developmental epileptic encephalopathies. We prospectively studied seizure onset before 3 months age. Based on clinical details, neuroimaging, metabolic comprehensive evaluation, were classified into different aetiological groups. The phenotypic differences between genetic/unknown groups remaining aetiologies compared. Factors that could affect control...
Factor VIII (FVIII) replacement and emicizumab have demonstrated efficacy for prevention of bleeds among patients with hemophilia A (PwHA) compared to on-demand (OD) use. Evidence investigating clinical outcomes healthcare costs non-inhibitor PwHA switching from prophylaxis FVIII concentrates has not been well-established within large real-world datasets. This study aimed investigate billed annualized bleed rates (ABRb) total cost care (TCC) FVIII-prophylaxis emicizumab-prophylaxis.This...
Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic condition which predisposes individuals to tumors of the nervous system, skin, bones, and eyes. Plexiform neurofibromas (PNs) occur in 20-50% NF1 cases, causing multiple morbidities conferring a risk malignancy. with PN poorly characterized literature regard treatment patterns, healthcare resource utilization, costs real world.This was retrospective analysis data from commercial claims database US between October 2014 March...
Objectives The objectives of this study were to describe the characteristics and initial treatment patterns, healthcare resource use (HCRU), costs patients newly diagnosed with neurofibromatosis type 1 (NF1)-related plexiform neurofibromas (PN).Methods This was a retrospective individuals enrolled in IBM MarketScan Multi-State Medicaid database from October 2014 31 December 2017. Patients aged ≤18 years at index date (first diagnosis NF1 or PN, whichever occurred later) least ICD-10-CM code...
<title>Abstract</title> Paediatric epilepsies have diverse etiologies from structural brain lesions to monogenic disorders. Prospective studies low-middle income countries which had used modern diagnostic methods like 3-T MRI and genetic testing for underlying causes in early-childhood epilepsies, are lacking. Similarly, data on long-term epilepsy outcomes is also not available. In this prospective study, consecutive patients with onset of till five years age were enrolled. Following...
<title>Abstract</title> Prospective research from low- and middle-income countries on aetiologies of early childhood epilepsies using advanced diagnostic methods (3T-MRI genetic testing), is lacking. Data epilepsy outcomes also not available in these patients. We enrolled consecutive patients with onset upto five years age, over 12 months. After ruling out a structural-acquired cause MRI, testing exome sequencing (ES) if required, chromosomal microarray (CMA)/multiplex ligand PCR assay...
Background Factor VIII (FVIII) replacement and emicizumab are effective at preventing bleeds in patients with hemophilia A (HA). Though benefits of among inhibitor HA (PwHA) well established, more real-world evidence non-inhibitor is needed.Methods Using a United States healthcare claims database, we compared billed annualized bleed rates (ABRb) the total cost care (TCC) before after switching from FVIII prophylaxis to male PwHA. Bayesian inferences were used assess difference ABRb TCC per...
To describe the economic burden among VWD patients with angiodysplasia compared to without and general population.This was a retrospective analysis using Merative MarketScan Commercial Medicare Databases® (January 2011-September 2020). Selected had ≥1 medical claim for or low VWF, AGD, ≥3 GI-related bleeding episodes within year. HCRU all-cause costs were (only) cohorts.The mean total $150,101 (n = 34), higher $48,249 matched 136) $31,029 individuals of population [n 136; p-value < 0.0001]....
In 2019, the United States (US) Advisory Committee on Immunization Practices (ACIP) recommended that healthcare providers engage in shared clinical decision making for adults aged 27–45 who may benefit from HPV vaccination. However, it is difficult to assess these benefits as there a lack of data burden young and mid-adult women. This analysis estimates incidence conization associated with treating pre-cancerous states related loop electrosurgical excision procedure (LEEP) or cold knife...
"HSR20-111: Characteristics, Treatment Patterns, Healthcare Resource Use and Costs among Pediatric Patients Diagnosed with Neurofibromatosis Type 1 Plexiform Neurofibromas: A Retrospective Database Analysis" published on 20 Mar 2020 by National Comprehensive Cancer Network.