A5103026910- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Fluorine in Organic Chemistry
- Crystallography and molecular interactions
- Cyclopropane Reaction Mechanisms
- Asymmetric Synthesis and Catalysis
- Inorganic Fluorides and Related Compounds
- Synthetic Organic Chemistry Methods
- Catalytic Cross-Coupling Reactions
- Cancer Treatment and Pharmacology
- Asymmetric Hydrogenation and Catalysis
- Catalytic C–H Functionalization Methods
- Sulfur-Based Synthesis Techniques
- Marine Sponges and Natural Products
- Traditional and Medicinal Uses of Annonaceae
- Synthesis of Organic Compounds
- Colorectal Cancer Treatments and Studies
- Synthesis and Catalytic Reactions
- Surface Chemistry and Catalysis
- HER2/EGFR in Cancer Research
- Bioactive Natural Diterpenoids Research
- Oxidative Organic Chemistry Reactions
- Advanced Synthetic Organic Chemistry
University of Hong Kong
2018
Shanghai Institute of Organic Chemistry
2013-2014
Chinese Academy of Sciences
2013-2014
Donghua University
2009-2010
A first example of Pd-catalyzed gem-difluoroallylation organoborons using 3-bromo-3,3-difluoropropene (BDFP) in high efficiency with α/γ-substitution regioselectivity has been developed. The reaction can also be extended to substituted BDFPs and advantages low catalyst loading (0.8 0.01 mol %), broad substrate scope, excellent functional group compatibility, thus providing a facile route for practical application drug discovery development.
PdF: A simple catalytic system, broad substrate scope, and high versatility provide a useful facile access to partially fluorinated aromatics (see scheme). Tuning the reaction conditions enables diverse range of product structures be prepared. As service our authors readers, this journal provides supporting information supplied by authors. Such materials are peer reviewed may re-organized for online delivery, but not copy-edited or typeset. Technical support issues arising from (other than...
A general and efficient method for the highly enantioselective alkynylation of ketoimines through a zinc/1,1'-bi-2-naphthol (BINOL)-catalyzed process has been developed. variety ketoimines, including α-fluoroalkyl α-imine esters, α-aryl trifluoromethyl aryl are applicable provide their corresponding quaternary propargyl amines in excellent yields with high ee values (up to 99 % ee). Both steric electronic effects substituents at 3,3' positions BINOL critical reaction efficiency...
PdF: Ein einfaches Katalysatorsystem und der breite Substratbereich sind das Geheimnis eines nützlichen effizienten Zugangs zu partiell fluorierten Arenen (siehe Schema). Durch gezielte Verändern Reaktionsbedingungen ließ sich ein vielfältiges Spektrum von Produktstrukturen erhalten. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed may be re-organized for online delivery, but not copy-edited or...
Abstract A practical and stereoselective synthesis of the C(9)–C(24) subunit (+)‐discodermolide has been achieved. The strategy featured construction key intermediate Z ‐trisubstituted vinyl iodide 12 from dibromo‐olefin 6 via an efficient modified Tanino‐Miyashita's approach. union two fragments was carried out through a Suzuki cross‐coupling reaction.
Abstract The presented method is applicable to a broad scope of organoboronic and bromo difluoro allyl compounds.
Abstract The efficient and versatile title reaction gives access to fluoroarenes which are difficult synthesize otherwise.
The title compound, C(11)H(14)F(2)O(4), is a γ,γ-gem-difluorinated α,β-unsaturated δ-lactone. dioxolane five-membered ring and the lactone adopt half-chair conformations. There are two inter-molecular C-H⋯O inter-actions involving carbonyl group as an acceptor which stabilize crystal structure.