A5028363614- Plant Molecular Biology Research
- Lipid metabolism and biosynthesis
- Photosynthetic Processes and Mechanisms
- Advanced Optical Network Technologies
- Advanced Software Engineering Methodologies
- melanin and skin pigmentation
- Plant nutrient uptake and metabolism
- Plant Reproductive Biology
- Optical Network Technologies
- Toxin Mechanisms and Immunotoxins
University of Pennsylvania
2022-2024
The Ohio State University
2021-2024
Abstract The CLASS III HOMEODOMAIN-LEUCINE ZIPPER (HD-ZIPIII) transcription factors (TFs) were repeatedly deployed over 725 million years of evolution to regulate central developmental innovations. START domain this pivotal class regulators was recognized 20 ago, but its putative ligands and functional contributions remain unknown. Here, we demonstrate that the promotes HD-ZIPIII TF homodimerization increases transcriptional potency. Effects on output can be ported onto heterologous TFs,...
Functional divergence of transcription factors (TFs) has driven cellular and organismal complexity throughout evolution, but its mechanistic drivers remain poorly understood. Here we test for new mechanisms using CORONA (CNA) PHABULOSA (PHB), two functionally diverged paralogs in the CLASS III HOMEODOMAIN LEUCINE ZIPPER (HD-ZIPIII) family TFs. We show that virtually all genes bound by PHB (~99%) are also CNA, ruling out occupation distinct sets as a mechanism functional divergence. Further,...
Functional divergence of transcription factors (TFs) has driven cellular and organismal complexity throughout evolution, but its mechanistic drivers remain poorly understood. Here we test for new mechanisms using CORONA (CNA) PHABULOSA (PHB), two functionally diverged paralogs in the CLASS III HOMEODOMAIN LEUCINE ZIPPER (HD-ZIPIII) family TFs. We show that virtually all genes bound by PHB ( ~ 99%) are also CNA, ruling out occupation distinct sets as a mechanism functional divergence....
Abstract HD-ZIPIII transcription factors (TFs) were repeatedly deployed over 725 million years of evolution to regulate central developmental innovations. The START domain this pivotal class regulators was recognized twenty ago, but its putative ligands and functional contributions remain unknown. Here, we demonstrate that the promotes TF homodimerization increases transcriptional potency. Effects on output can be ported onto heterologous TFs, consistent with principles via capture. We also...