A5069730949- Photosynthetic Processes and Mechanisms
- Microtubule and mitosis dynamics
- Nitric Oxide and Endothelin Effects
- Protist diversity and phylogeny
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nuclear Structure and Function
- RNA Research and Splicing
- Lipid metabolism and biosynthesis
University of Cambridge
2019
University of Pavia
2019
Abstract The midbody is an organelle assembled at the intercellular bridge between two daughter cells end of mitosis. It controls final separation and has been involved in cell fate, polarity, tissue organization, cilium lumen formation. Here, we report characterization intricate protein-protein interaction network (interactome), which identifies many previously unknown interactions provides extremely valuable resource for dissecting multiple roles midbody. Initial analysis this interactome...
It is now accepted that reactive oxygen species (ROS) are not only dangerous oxidative agents but also chemical mediators of the redox cell signaling and innate immune response. A central role in ROS‐controlled production played by NADPH oxidases (NOXs), a group seven membrane‐bound enzymes (NOX1‐5 DUOX1‐2) whose unique function to produce ROS. Here, we describe regulation NOX5, widespread family member present cyanobacteria, protists, plants, fungi, animal kingdom. We show calmodulin‐like...
3' end processing of most eukaryotic pre-mRNAs is a crucial co-transcriptional process that generally involves the cleavage and polyadenylation precursor transcripts. Within human 3’ machinery, 4-subunit mammalian specificity factor (mPSF) recognizes signal (PAS) in pre-mRNA recruits polyA polymerase α (PAPOA) to it. To shed light on molecular mechanisms PAPOA recruitment mPSF, we used combination cryogenic-electron microscopy (cryo-EM) single-particle analysis, computational structure...
Abstract The midbody is an organelle assembled at the intercellular bridge that connects two daughter cells end of mitosis. It composed a multitude proteins, organized in precise and stereotyped pattern, control final separation prevent incorrect genome segregation. Furthermore, recent evidence indicates involved many other important processes, including cell fate, pluripotency, apical-basal polarity, tissue organization, cilium lumen formation. Understanding regulation interactions proteins...