A5042772361- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Alzheimer's disease research and treatments
- Nitric Oxide and Endothelin Effects
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ubiquitin and proteasome pathways
- Phytoestrogen effects and research
- Polymer Surface Interaction Studies
- Advanced Glycation End Products research
- Protein purification and stability
- Photosynthetic Processes and Mechanisms
- DNA Repair Mechanisms
- Surface Modification and Superhydrophobicity
- Fungal and yeast genetics research
- Prion Diseases and Protein Misfolding
- Protein Structure and Dynamics
King's College London
2018-2020
UK Dementia Research Institute
2018-2020
University of Leeds
2012
University of Florence
2009
It is now accepted that reactive oxygen species (ROS) are not only dangerous oxidative agents but also chemical mediators of the redox cell signaling and innate immune response. A central role in ROS‐controlled production played by NADPH oxidases (NOXs), a group seven membrane‐bound enzymes (NOX1‐5 DUOX1‐2) whose unique function to produce ROS. Here, we describe regulation NOX5, widespread family member present cyanobacteria, protists, plants, fungi, animal kingdom. We show calmodulin‐like...
Ataxin-3 is the protein responsible for neurodegenerative polyglutamine disease Spinocerebellar ataxia type 3. Full structural characterisation of ataxin-3 required to aid in understanding mechanism disease. Despite extensive study, little known about conformational properties full-length protein, either its non-expanded healthy or expanded pathogenic forms, particularly since polyglutamine-containing region has denied elucidation. In this work, travelling-wave ion mobility spectrometry-mass...
Abstract It has increasingly become clear over the last two decades that proteins can contain both globular domains and intrinsically unfolded regions which contribute to function. While equally interesting, disordered are difficult study because they usually do not crystallize unless bound partners easily amenable cryo-electron microscopy studies. Nuclear magnetic resonance spectroscopy remains best technique capture structural features of mixed folded describe their dynamics. These studies...