A5061781819- Mesenchymal stem cell research
- Pancreatic function and diabetes
- Pancreatic and Hepatic Oncology Research
- Tissue Engineering and Regenerative Medicine
- Colorectal Cancer Screening and Detection
- Cancer Cells and Metastasis
- Periodontal Regeneration and Treatments
- Colorectal Cancer Surgical Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Health Systems, Economic Evaluations, Quality of Life
- Lysosomal Storage Disorders Research
- Prion Diseases and Protein Misfolding
- Biomedical Ethics and Regulation
- Colorectal Cancer Treatments and Studies
- Renal and related cancers
- Single-cell and spatial transcriptomics
- Pluripotent Stem Cells Research
- Neonatal Respiratory Health Research
- CRISPR and Genetic Engineering
- Global Cancer Incidence and Screening
- Nuclear Structure and Function
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2024-2025
University of Milan
2024
Ferrari (Italy)
2024
Sabin Vaccine Institute
2020
Dental pulp has been revealed as an accessible and a rich source of mesenchymal stem cells (MSCs) its biological potential is currently under intense investigation. MSCs from dental (DPSCs) have indicated heterogeneous population oriented not only in repairing dentine but also maintaining vascular nervous homeostasis the teeth. We sought to verify phenotype isolated young donors investigate vitro their role pericyte-like cells. Specifically, we evaluated how culture conditions can modulate...
Human organoids have been proposed to be powerful tools mimicking the physiopathological processes of organs origin. Recently, human pancreatic (hPOs) gained increasing attention due potential theragnostic and regenerative medicine applications. However, cellular components hPOs not defined precisely. In this work, we finely characterized these structures, focusing first on morphology identity-defining molecular features under long-term culture conditions. Next, focused our cell type...
Mesenchymal stromal cells (MSC) play a critical role in the stem cell niche, specialized microenvironment where reside and interact with surrounding extracellular matrix components. Within MSC offer structural support, modulate inflammatory response, promote angiogenesis release specific signaling molecules that influence behavior, including self-renewal, proliferation differentiation. In epithelial tissues such as intestine, stomach liver, act an important source of cytokines growth...
Background Recently, mesenchymal stromal cells (MSCs) have gained recognition for their clinical utility in transplantation to induce tolerance and improve/replace pharmacological immunosuppression. Cord blood (CB)-derived MSCs are particularly attractive immunological naivety peculiar anti-inflammatory anti-apoptotic properties. Objectives: The objective of this study was obtain an inventory CB able support large-scale advanced therapy medicinal product (ATMP)-based trials. Study design: We...
Introduction Human induced pluripotent stem cells (hiPSCs), derived from reprogrammed adult somatic cells, hold significant promise for disease modelling, personalized medicine, drug discovery, and regenerative therapies. Public awareness understanding of hiPSCs are crucial advancing research in this field. However, limited data exists on the general population’s knowledge attitudes toward their use. Methods This study aimed to assess perceptions among Italian adults through a web-based...
The aim of the present study was to estimate total cancer mortality trends from 1982 2011 in a "low rate land use" province Latium region (Rieti, central Italy) characterized by low degree urbanization, high prevalence elderly, and number births. Mortality data studied period, provided Italian National Institute Statistics, were used for calculating standardized rates. Trends analyzed using Joinpoint regression analysis. Results showed that rates decreased monitored area over period. A...
Lipid rafts are signaling microdomains enriched in glycosphingolipids, cholesterol, tyrosine kinase receptors, mono‐ or heterotrimeric G proteins and GPI‐anchored proteins. This dynamic assemblage of several components dissociate associate rapidly forming, cell membranes, functional clusters which provide highly efficient lipid–protein modules operating membrane trafficking signaling. Indeed, lipid thought to function as platforms that sequestrate specific proteins, permanently transiently,...