A5068039274- Sleep and Wakefulness Research
- Neonatal and fetal brain pathology
- Circadian rhythm and melatonin
- Poisoning and overdose treatments
- Parkinson's Disease Mechanisms and Treatments
- Neurobiology and Insect Physiology Research
- Restless Legs Syndrome Research
- Neonatal Respiratory Health Research
- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Adolescent and Pediatric Healthcare
- Neuroinflammation and Neurodegeneration Mechanisms
- Pediatric health and respiratory diseases
- COVID-19 Clinical Research Studies
- Childhood Cancer Survivors' Quality of Life
- Vitamin C and Antioxidants Research
- Mechanical Circulatory Support Devices
- Drug-Induced Adverse Reactions
- Lipid metabolism and biosynthesis
- Vitamin K Research Studies
- Sepsis Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Clinical Nutrition and Gastroenterology
- Neurogenesis and neuroplasticity mechanisms
- Case Reports on Hematomas
Children's National
2020-2025
National Hospital
2022-2024
George Washington University
2024
National Research Institute
2024
Gladstone Institutes
2018-2024
Jefferson Hospital for Neuroscience
2023
UCSF Benioff Children's Hospital
2018-2021
University of California, San Francisco
2018-2020
Anna Needs Neuroblastoma Answers
2020
Penn Center for AIDS Research
2016
Abstract Background Traumatic brain injury (TBI) causes significant blood-brain barrier (BBB) breakdown, resulting in the extravasation of blood proteins into brain. The impact proteins, especially fibrinogen, on inflammation and neurodegeneration post-TBI is not fully understood, highlighting a critical gap our comprehension TBI pathology its connection to innate immune activation. Methods We combined vascular casting with 3D imaging solvent-cleared organs (uDISCO) study spatial...
Sleep is under the control of homeostatic and circadian processes, which interact to determine sleep timing duration, but mechanisms through system modulates are largely unknown. We therefore used adult-specific, temporally controlled neuronal activation inhibition identify an interaction between clock a novel population sleep-promoting neurons in Drosophila.Transgenic flies expressed either dTRPA1, activator, or Shibire(ts1), inhibitor synaptic release, small subsets neurons. Sleep, as...
In critically ill newborns, exposure to hypercapnia (HC) is common and often accepted in neonatal intensive care units prevent severe lung injury. However, as a “safe” range of arterial partial pressure carbon dioxide levels neonates has not been established, the potential impact HC on neurodevelopmental outcomes these newborns remains matter concern. Here, newborn Yorkshire piglet model either sex, we show that acute induced persistent cortical neuronal injury, associated cognitive learning...
The quiver/sleepless (qvr/sss) gene encodes a small, glycosylphosphatidylinositol-anchored protein that plays critical role in the regulation of sleep Drosophila. Loss-of-function mutations qvr/sss severely suppress and effect multiple changes situ Shaker K(+) currents, including decreased magnitude, slower time-to-peak, cumulative inactivation. Recently, we demonstrated SLEEPLESS (SSS) modulates channel activity, possibly through direct interaction at plasma membrane. We show here SSS...
We report a case of six-year-old boy who presented after cardiac arrest, likely due to pulmonary hypertensive crisis in the setting vitamin C deficiency. After initially presenting with subacute multifocal bone lesions unknown etiology, he experienced pulseless electrical activity arrest while undergoing diagnostic procedure under sedation. During his post-arrest convalescence, developed persistent tachycardia and peripheral edema. An echocardiogram revealed findings consistent significant...
OBJECTIVES: To examine the relationship between adequacy of caloric nutritional support during first week after severe traumatic brain injury (TBI) and outcome. DESIGN: Single-center retrospective cohort, 2010–2022. SETTING: Tertiary care children’s hospital with a level 1 trauma center. PATIENTS: Children younger than 18 years PICU stay greater 7 days for management TBI, who had defined as Glasgow Coma Scale (GCS) score less or equal to 8 at initial presentation and/or placement an...
Abstract We evaluated rest effects on restless legs syndrome (RLS) sensory and motor symptoms. During two 60‐minute Suggested Immobilization Tests (SIT) subject's signals of RLS leg sensations periodic movements while awake (PLMW) were recorded. Sensations, PLMW, preceding or after occurring without following PLMW sensation determined. The patients divided into equal‐sized high low groups for further analysis. Data from 46 subjects (28 18 controls) revealed increased linearly with in...
Abstract Introduction Survivors of childhood cancers undergo routine pulmonary function testing as they are at an increased lifetime risk for significant lung disease. However, this population also demonstrates growth abnormalities that could influence the interpretation these tests, reference equations based on standing height. We aim to determine impact relative thoracic deficiency in cancer survivors testing. Methods Standing height and upper segment length (USL) undergoing a single...
The molecular circadian clock can be found throughout the body and is essential for synchronizing cellular physiology with 24 h day. However, role of in regulating regenerative potential brain has not been explored. We report here that murine NG2-glia, largest population proliferative cells mature central nervous system, rhythmically express genes a period, including critical component Bmal1 RNA BMAL1 protein. Interestingly, daily NG2-glia proliferation preferentially occurs during time day...
Neonatal hypoxia (Hx) causes white matter (WM) injury, particularly in the cerebellum. We previously demonstrated Hx-induced reduction of cerebellar Purkinje cell (PC) activity results locomotor deficits. Yet, mechanism WM injury and associated abnormalities remains undetermined. Here, we show that linked deficits are driven by PC reversed when is restored. Using optogenetics multielectrode array recordings, manipulated captured resulting cellular responses oligodendrocyte precursor cells...
Traumatic brain injury (TBI) is a leading cause of pediatric morbidity and mortality. This study first investigates clinical characteristics continuous electroencephalography (cEEG) parameters associated with short-term functional outcomes in patients following TBI. Second, we use these data for hypothesis-generating model about outcomes.
The guideline article “Management of hypersensitivity to platinum- and taxane-based chemotherapy: cepo review clinical recommendations” in this journal for the management reactions (HSR) group chemotherapy agents is useful practice [...]
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