A5005616066- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Appendicitis Diagnosis and Management
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Colorectal Cancer Screening and Detection
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Colorectal and Anal Carcinomas
- Abdominal vascular conditions and treatments
- Trauma and Emergency Care Studies
- Acute Kidney Injury Research
- Liver Disease and Transplantation
- Radiopharmaceutical Chemistry and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer, Lipids, and Metabolism
- Hemodynamic Monitoring and Therapy
- Neuroendocrine Tumor Research Advances
- Intestinal and Peritoneal Adhesions
- Surgical site infection prevention
- Radiomics and Machine Learning in Medical Imaging
- Abdominal Surgery and Complications
- Biliary and Gastrointestinal Fistulas
- TGF-β signaling in diseases
- Leprosy Research and Treatment
Wakayama Medical University
2011-2024
Kyoto Katsura Hospital
2024
Creative Commons
2023
Wakayama Rosai Hospital
2014
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is known to be downregulated at the transcriptional level in adenoma and carcinoma. Recent reports have shown that CEACAM1 overexpressed protein colorectal cancer correlated with clinical stage. The reason why cells re-expressed remains unclear. aim of our study was clarify implication re-expression cancer. Immunohistochemical analyses were conducted long (CEACAM1-L) or short (CEACAM1-S) cytoplasmic domain-specific...
This study is an attempt to clarify the role of C-reactive protein (CRP) as a surgical indication marker for appendicitis.One hundred and fifty patients who underwent appendectomies had pathologically confirmed appendicitis were reviewed between May 1, 1999 September 31, 2007. The correlation preoperative clinical factors actual histological severity, identify markers assessed by univariate multivariate analyses.Univariate analysis showed that only CRP level significantly differ treatment...
Abstract Purpose: The aim of this study is to identify gene expression signatures that accompany dedifferentiation at the cancer invasion front in colorectal cancer. Experimental Design: Two types were selected. Both well-differentiated adenocarcinomas superficial lesion. One type showed a dedifferentiated phenotype (type A, 13 samples); other almost no cells B, 12 samples). Laser microdissection was combined with cDNA microarray analysis investigate lesions and cancers. Results:...
There are increasing reports showing the clinical significance of p53 polymorphism status in terms response to chemotherapy. We investigated whether and mutation were associated with vitro sensitivity 5-fluorouracil (5-FU) patients colorectal cancer. Chemosensitivity 5-FU was evaluated by collagen gel droplet embedded culture drug test. tumor cells without inactive arginine/arginine (Arg/Arg) variant significantly higher than that or other variants (p = 0.022), whereas Arg/Arg lower 0.002)....
We report the case of a patient for whom surgical hemostasis gastrointestinal bleeding due to splenic artery pseudoaneurysm, which developed gastric ulcer penetration, was achieved with resuscitative endovascular balloon occlusion aorta without ischemia organs including spleen.
Objective Tumour budding formed by histologically undifferentiated cancer cells beyond the border of tumour margin is associated with lymph node metastasis. However, hollow nests, a possible advanced phenotype budding, have not been discussed. We examined whether spheroids exist invasive and are metastasis prognosis. Moreover, we suggest that carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) isoform balance spheroid formation. Methods Immunohistochemical analyses CEACAM1...
The utility of resuscitative endovascular balloon occlusion the aorta (REBOA) in children remains unclear.
Acute kidney injury (AKI) after trauma is a major complication independently associated with prolonged hospital stay and increased mortality. We previously reported that the prehospital systolic blood pressure (SBP) early arterial lactate level, along specific cut-off values, show good performance in prediction of AKI using AUC-ROC [1]. The purpose this study was to prospectively validate whether or not these parameters are predictive newly occurring trauma.This prospective review patients...
This study evaluated the impact of obesity on learning to perform laparoscopic surgery for colon cancer.We compared outcomes 72 patients with cancer treated by a single surgeon between June 2005 and July 2008. The first 36 who underwent were considered be during "early period," other as "late body mass index (BMI) ≥25 kg/m(2) defined being obese.During early period, tumor stages obese less advanced than those nonobese patients, whereas length operation, surgical blood loss, wound diameter...
Abstract Background The differences between the metastatic property of moderately (Mod) and well (Wel) differentiated colorectal adenocarcinoma remain unclear. Since Mod is unable to form complete acini, therefore an epithelial-mesenchymal transition (EMT) can occur in that structure. Herein, we hypothesized metastasizes more easily than Wel counterparts. Methods medical records 283 consecutive patients with (n = 71) or 212) who underwent surgery were reviewed January 1, 2001, December 31,...
症例は67歳，男性，右季肋部痛と発熱を主訴に来院した．腹部MRIで肝前区域を中心とする腫瘍を認め，肝亜区域切除・胆嚢摘出・十二指腸部分切除・横行結腸部分切除を施行，H.E.染色では低分化型胆管細胞癌であった．術後30病日ごろから口渇・多飲・多尿・全身倦怠感および見当識の低下を認めた．高血糖や骨転移は認めず，Ca と PTHrP の上昇（14.6mg/ml，7.0pmol/l）を認めた．ただちにcalcitoninおよびzoredronateを投与し，症状緩和は得られたが，まもなく播種性の再発が生じ，術後64病日に死亡した．免疫組織学的検討では，CEA，cytokeratin（CK）-7，CK-8，CK-19，PTHrPが陽性，AFP，hepatocyte specific antigen（HSA），CK-20，PTHが陰性であったことから，最終的にPTHrP産生胆管細胞癌と診断した．
症例は80歳，女性．1カ月以上続く便柱狭細化と便秘を主訴に前医を受診し，下部消化管内視鏡検査（colonoscopy，以下CS）で直腸粘膜の全周性浮腫と狭窄を指摘された．以前よりCEA高値を指摘されており，精査目的で当院紹介．内視鏡下生検組織診断で悪性所見は認めなかったが，継続する全周性直腸狭窄とCEA高値より直腸癌を否定できず，開腹術を施行した．しかし，直腸および骨盤内に腫瘍を認めなかった．術中にCSをしたところ，直腸の狭窄は改善していたため直腸切除は行わず，保存的に経過をみることとした．一週間後に再びCSを行ったところ，軽度の直腸狭窄を認めたのみであり，直腸狭窄型虚血性大腸炎と診断した．直腸狭窄型虚血性大腸炎は比較的まれであり，さらにCEA高値を伴った症例はこれまでにほとんど報告がなく，若干の文献的考察を加えて報告する．
Purpose: This study evaluated the impact of pelvic pillow on a single surgeon’s learning how to perform laparoscopic low anterior resection (LAR) for rectal cancer. Methods: We compared outcomes 23 patients with cancer including first 11 who underwent LAR without pillow, and latter 12 by surgeon. Results: The stage (+) was more advanced than that (−). length operation postoperative start oral intake were shorter earlier those surgical field in better allowed evaluation Conclusions:...