A5043199850- Cannabis and Cannabinoid Research
- Palliative Care and End-of-Life Issues
- Frailty in Older Adults
- Cancer survivorship and care
- Diet, Metabolism, and Disease
- Cancer-related cognitive impairment studies
- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Cancer Research and Treatments
- Religion, Spirituality, and Psychology
- Bipolar Disorder and Treatment
- Virus-based gene therapy research
- Homelessness and Social Issues
- Economic and Financial Impacts of Cancer
- Nutrition and Health in Aging
- Family and Patient Care in Intensive Care Units
- PARP inhibition in cancer therapy
- Patient Dignity and Privacy
- Healthcare professionals’ stress and burnout
- Perfectionism, Procrastination, Anxiety Studies
- Food Security and Health in Diverse Populations
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Lymphoblastic Leukemia research
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
The Ohio State University
2021-2025
The Ohio State University Wexner Medical Center
2021-2025
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute
2023-2024
All India Institute of Medical Sciences
2023
University Hospital Waterford
2023
Pfizer (United States)
2023
Soochow University
2023
Intermountain Healthcare
2023
University of Michigan
2023
Prevea Health
2021-2022
We studied the functional role and modulation of hyperpolarization-activated inward current (I(h)) in pyloric network lobster stomatogastric ganglion. In isolated neurons, I(h) is a small with hyperpolarized voltage half-activation (V(Act)) slow time constant activation (tau(Act)). Bath application dopamine (DA), octopamine (OCT), or serotonin (5HT) modified selected synaptically neurons. DA significantly enhanced anterior burster (AB) neuron by depolarizing its V(Act), accelerating...
SUMMARY Nine patients with adult acute leukemia were treated in relapse piperazinedione plus supralethal total body irradiation conjunction autologous marrow infusion. Bone cells collected and stored first remission. Storage time varied from 3 to 23 months. Before storage, separated using density albumin gradients order reduce the number of leukemic graft. Three died before day 14 after transplantation because complications already present at transplantation. In six patients, hemopoietic...
Background: Oncologists often struggle with managing the unique care needs of older adults cancer. This study sought to determine feasibility delivering a transdisciplinary intervention targeting geriatric-specific (physical function and comorbidity) palliative (symptoms prognostic understanding) advanced Methods: Patients aged ≥65 years incurable gastrointestinal or lung cancer were randomly assigned usual care. Those in arm received 2 visits geriatrician, who addressed patients’ conducted...
Symptoms such as pain, nausea, and anxiety are common in individuals with cancer. Treatment of these issues is often challenging. Cannabis products may be helpful reducing the severity symptoms. While some studies include data on prevalence cannabis use among patients cancer, detailed remain limited, none have reported cannabidiol (CBD) this population. Adult cancer attending eight clinics at a large, NCI-designated Comprehensive Cancer Center completed detailed, cannabis-focused...
Abstract Purpose There is increasing interest in the use of cannabis products to alleviate symptom burden among cancer patients. Although data remain limited, some evidence suggests that state legalization associated with reduced opioid use. Indices area-level social determinants health may provide insights into patterns symptom-managing behaviors context equity. Methods Residential ZIP codes from 854 Ohio residents diagnosed invasive at an academic center were used assign rural–urban...
Background: Patients with end-stage liver disease (ESLD) have complex needs and may benefit from palliative care (PC), which is often underutilized or delayed. Objectives: To characterize patients ESLD who received inpatient PC consultation to explore differences in characteristics between those before (pre-Pall) after (post-Pall) participation at weekly transplant (LT) Patient Selection Committee (PSC) meetings. Design: Single-center retrospective cohort study. Setting/Subjects:...
Abstract Background National studies reporting the prevalence of cannabis use have focused on individuals with a history cancer without distinction by their treatment status, which can impact symptom burden. While pain is primary motivation to in cancer, magnitude its association remains understudied. Methods We examined and management among 5523 respondents Behavioral Risk Factor Surveillance System history. Survey-weighted proportions respondents’ are reported, stratified status....
Lesbian, gay bisexual, transgender, and queer or questioning (LGBTQ) older adults have unique health care needs, especially in the palliative hospice setting. In this article, we present a male patient with metastatic ovarian cancer, admitted worsening dyspnea, now at end of life. Only his wife was aware identified gender, nondisclosure very important to him. As he continued decline, team navigated LGBTQ-sensitive within setting, insurance inequalities, support communication family. This...
The incidence of hematologic malignancies (HMs) is highest in the seventh decade life and coincides with increasing occult, age-related vulnerabilities. Identification frailty useful prognostication treatment decision-making for older adults HMs. This real-world analysis describes 311 HMs evaluated a multidisciplinary oncogeriatric clinic. accumulation geriatric conditions [1-unit increase, hazards ratio (HR) = 1.13, 95% CI 1.00-1.27, p 0.04] assessed by Rockwood Clinical Frailty Scale (CFS,...
Objective Women make up a majority of the gynecologic oncology workforce. Increasing numbers women in leadership has been proposed as path towards professional gender equity. This study examined whether and departmental infrastructure impact work environment for oncologists. Methods Members 472-member private Facebook group “Women Gynecologic Oncology” (WGO) who self-identified oncologists provided demographics, practice infrastructure, personal experience with workplace bullying,...
Background: Older cancer survivors in general are at greater risk for cancer-related cognitive impairment (CRCI), yet few studies have explored its association with health outcomes. This study examined the between subjective and objective measures of function physical function, frailty, quality life (QoL) among older breast survivors. Materials Methods: who reported concerns completed surveys on patient-reported QoL as well tests visuospatial working memory sustained attention. Data were...
3002 Background: Recent studies have shown poor clinical outcomes and limited survival advantage to checkpoint inhibitors (CIs) in advanced stage ovarian cancer (OvC). Vigil is a personalized precision vaccine constructed from autologous tumor tissue transfected with DNA plasmid encoding GM-CSF bi-shRNA-furin thereby creating TGFβ expression control enhancing immune activation. Phase 1 2 trials OvC demonstrate safety, functional activation response benefit. Combining CIs may broaden...