A5017389204- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Chronic Lymphocytic Leukemia Research
- Lung Cancer Treatments and Mutations
- Dermatology and Skin Diseases
- Neurobiology and Insect Physiology Research
- Ion Channels and Receptors
- Cancer Research and Treatments
- Circadian rhythm and melatonin
- Phagocytosis and Immune Regulation
- COVID-19 Clinical Research Studies
- Ovarian cancer diagnosis and treatment
- Photoreceptor and optogenetics research
- Colorectal Cancer Treatments and Studies
- CAR-T cell therapy research
- Chronic Myeloid Leukemia Treatments
- Immunotherapy and Immune Responses
- Lung Cancer Research Studies
- Eosinophilic Disorders and Syndromes
- Antibiotic Resistance in Bacteria
- Health disparities and outcomes
- SARS-CoV-2 and COVID-19 Research
- Pancreatic and Hepatic Oncology Research
- Pain Mechanisms and Treatments
- Mental Health Research Topics
Jiangsu University
2019-2025
Southwest University of Science and Technology
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2024
First People's Hospital of Yunnan Province
2009-2024
Kunming University of Science and Technology
2024
The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture
2024
State Key Laboratory of Biotherapy
2024
The University of Texas Southwestern Medical Center
2023-2024
Sichuan University
2024
Affiliated Hospital of Southwest Medical University
2017-2023
The COVID-19 epidemic has caused increasing public panic and mental health stress. In this study, we explore the prevalence factors linked to anxiety depression in hospitalized patients with COVID-19. A total of 144 diagnosed underwent assessment by using Hospital Anxiety Depression Scale (HADS). Social support level was also evaluated Perceived Support (PSSS) at admission. Results showed that gender, age, oxygen saturation, social were associated for patients. addition, family infection...
Abstract Circadian rhythms are orchestrated by a master clock that emerges from network of circadian pacemaker neurons. The is synchronized to external light/dark cycles through photoentrainment, but the circuit mechanisms underlying visual photoentrainment remain largely unknown. Here, we report Drosophila has eye-mediated via parallel neuron organization. Patch-clamp recordings central neurons reveal light excites most them independently one another. We also show light-responding send...
Vision enables both image-forming perception, driven by a contrast-based pathway, and unconscious non-image-forming circadian photoentrainment, an irradiance-based pathway1,2. Although two distinct photoreceptor populations are specialized for each visual task3-6, photoreceptors can additionally contribute to photoentrainment of the clock in different species7-15. However, it is unknown how pathway functionally implement segregation irradiance signals required from contrast image perception....
Histamine H4 receptor has been confirmed to play a role in evoking peripheral pruritus. However, the ionic and intracellular signaling mechanism of activation on dorsal root ganglion (DRG) neurons is still unknown. By using cell culture calcium imaging, we studied underlying DRG neuron. Immepip dihydrobromide (immepip)—a histamine special agonist under cutaneous injection—obviously induced itch behavior mice. Immepip-induced scratching could be blocked by TRPV1 antagonist AMG9810 PLC pathway...
The master circadian clock generates 24-hour rhythms to orchestrate daily behavior, even running freely under constant conditions. Traditionally, the is considered self-sufficient in sustaining free-running timekeeping via its cell-autonomous molecular clocks and interneuronal communications within neural network. Here, we find a set of bona fide ultradian oscillators Drosophila brain that support timekeeping, despite being located outside circuit lacking gene expression. These extra-clock...
AimsCoronavirus disease (COVID-19), also referred to as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is instigated by a novel coronavirus. The was initially reported in Wuhan, China, December 2019. Diabetes risk factor associated with adverse outcomes. Herein, our objective investigate the characteristics of laboratory findings type diabetes mellitus (T2DM) patients infected SARS-CoV-2.MethodsThis retrospective study and included 80 T2DM Jinling Hospital from 2010 2020, well...
Chronic myeloid leukemia is successfully managed by imatinib therapy, but the question remains whether treatment must be administered indefinitely. Imatinib discontinuation trials have led to two distinct outcomes: about 60% of patients experienced disease relapse within 6 months cessation, while remaining 40% remained disease-free throughout duration follow-up. We aimed investigate mechanisms underlying these disparate clinical outcomes.We utilized molecular data from "Stop Imatinib" trial...
Abstract Osthole, an active coumarin isolated from Cnidium monnieri (L.) Cusson, has long been used in China as antipruritic herbal medicine; however, the antipruitic mechanism of osthole is unknown. We studied molecular histamine-dependent itch by behavioral test, Ca 2+ imaging and electrophysiological experiments. First, clearly remitted scratching behaviors mice induced with histamine, HTMT VUF8430. Second, cultured dorsal root ganglion (DRG) neurons, showed a dose-dependent inhibitory...
BackgroundBavituximab is a monoclonal antibody that targets phosphatidylserine in the presence of β2 glycoprotein 1 (β2GP1) to exert an antitumor immune response. This phase III trial determined efficacy bavituximab combined with docetaxel patients previously treated advanced non-small-cell lung cancer (NSCLC).Patients and methodsKey eligibility criteria included non-squamous NSCLC disease progression after treatment platinum-based doublet chemotherapy, evidence control at least two cycles...
Abstract Background Mobile phone dependence and mental health problems have become increasingly prominent among left-behind adolescents in China. In recent years, some studies focused on the important role of parent–child relationship psychological resilience. Therefore, this study aims to explore multidimensional relationships resilience, health, mobile adolescents, assess impact conflict level these relationships. Methods The Brief Symptom Inventory (BSI-18), Chinese version Phone...
PD-1 immune checkpoint blockade (ICB) with platinum chemotherapy (ChemoIO) has transformed treatment for resectable non-small cell lung cancer (NSCLC). ICB was established and created to reinvigorate tumor T cells reduce exhaustion. However, the impact of on induction maintenance tumor-relevant tdLN functional memory in context surgical resection is not fully understood. We hypothesized that activated draining lymph node (tdLN) also respond PD-I ICB. assessed clonal dynamics tumor-specific...
BACKGROUND Common variable immunodeficiency (CVID) is a primary antibody disorder characterized by diminished IgG levels. Despite ongoing research, the precise pathogenesis of CVID remains unclear. Genetic factors account for only 10%-20% cases, with an estimated incidence 1 in 10000 to 100000, affecting individuals across all age groups. CASE SUMMARY We report case 32-year-old man who presented chief complaint “recurrent diarrhea and significant weight loss over past 2 years”. Laboratory...
Immunotherapy brought long-term benefits for partial patients with lung squamous cell carcinoma (LUSC). The predictor of anti-PD-L1 therapy was controversial and limited in LUSC. We aimed to explore novel biomarker LUSC immunotherapy the potential mechanism. Five hundred twenty-five Chinese (Geneplus cohort) underwent targeted sequencing were involved genomic profiling. TP53 LRP1B most frequently recurrent genes correlated higher tumor mutational burden (TMB). observed that co-wild (co-wild...
Treatment with the tyrosine kinase inhibitor imatinib is standard of care for newly diagnosed patients chronic myeloid leukemia. In recent years, several second-generation inhibitors - such as dasatinib and nilotinib have become available: these promise to overcome some mutations associated acquired resistance imatinib. Despite eliciting similar clinical responses, molecular effects agents on different subpopulations leukemic cells remain incompletely understood. Furthermore, consequences...
Uterine contraction-induced pain (UCP) represents a common and severe form of visceral pain. Nerve fibers that innervate uterine tissue express the transient receptor potential vanilloid channel 1 (TRPV1), which has been shown to be involved in perception UCP. The phosphoinositide-interacting regulator TRP (Pirt) may act as regulatory subunit TRPV1. intraperitoneal injection oxytocin into female mice after 6-day priming treatment with estradiol benzoate induces writhing responses, reflect...
Chronic itch (pruritus) is an important clinical problem. However, the underlying molecular basis has yet to be understood. The Transient Receptor Potential Vanilloid 1 channel a heat-sensitive cation expressed in primary sensory neurons and involved both thermosensation pain, but its role chronic remains elusive. Here, we for first time revealed increased innervation density of 1-expressing fibers skin afflicted with itch. Further analysis indicated that this phenomenon due expansion under...