A5062525338- Pancreatic function and diabetes
- Diabetes and associated disorders
- Diabetes Management and Research
- Adipose Tissue and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Ovarian function and disorders
- Diet, Metabolism, and Disease
- Apelin-related biomedical research
- Regulation of Appetite and Obesity
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Heart Rate Variability and Autonomic Control
- Adipokines, Inflammation, and Metabolic Diseases
- MicroRNA in disease regulation
- Blood Pressure and Hypertension Studies
- Liver Disease Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Ophthalmology and Eye Disorders
- Cancer-related Molecular Pathways
- Growth Hormone and Insulin-like Growth Factors
- Reproductive Biology and Fertility
- Neurological Disease Mechanisms and Treatments
- Hormonal Regulation and Hypertension
- Cardiovascular Health and Disease Prevention
- Protein Tyrosine Phosphatases
Nanjing University
2013-2024
Nanjing General Hospital of Nanjing Military Command
2014-2024
Nanjing Medical University
2019-2024
Southeast University
2021-2024
First Affiliated Hospital of Guangzhou Medical University
2024
Guangzhou Medical University
2024
Anhui Medical University
2023
Southern Medical University
2013-2022
Army Medical University
2021
Jiangsu Provincial Hospital of Traditional Chinese Medicine
2015
Abstract Efficient clearance of apoptotic cells (efferocytosis) can profoundly influence tumor-specific immunity. Tumor-associated macrophages are M2-polarized that promote key processes in tumor progression. Efferocytosis stimulates M2 macrophage polarization and contributes to cancer metastasis, but the signaling mechanism underlying this process is unclear. Intercellular cell adhesion molecule-1 (ICAM-1) a transmembrane glycoprotein member immunoglobulin superfamily, which has been...
Summary Context Graves’ orbitopathy ( GO ) is a potentially sight‐threatening disease for which currently available medical therapy not reliably successful. Mycophenolate mofetil MMF selective immunosuppressant used widely in many autoimmune diseases. Preliminary studies have shown that effective the treatment of active . Objective To evaluate efficacy and safety patients with moderate‐to‐severe Patients One hundred 74 were randomized to receive either or glucocorticoids GC ). Main Outcome...
Objective . The objective of this study is to investigate the relationship between time in range (TIR), a new metric continuous glucose monitoring (CGM) and cardiovascular autonomic neuropathy (CAN) individuals with type 2 diabetes mellitus (T2DM). Methods A total 349 T2DM were enrolled study. Evaluating by standard cardiac reflex tests (CARTs), there 228 diabetic without (without confirmed CAN) including absent CAN (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"...
Background The associations of oral contraceptive (OC) use with cardiovascular disease (CVD) and all-cause death remains unclear. We aimed to determine the OC incident CVD death. Methods Results This cohort study included 161 017 women who had no at baseline reported their use. divided into ever never Cox proportional hazard models were used calculate ratios 95% CIs for outcomes Overall, 131 (81.4%) participants baseline. multivariable-adjusted users versus 0.92 (95% CI, 0.86-0.99) death,...
Background and Aim Atypical coronary artery disease (ACAD) is characterized by atypical angina pectoris or silent myocardial ischemia. However, conventional diagnostic techniques are insufficient to identify this subtype of atherosclerotic pathology, specific sensitive markers for diagnosing ACAD still currently lacking. The aim the present study a novel serum microRNA (miRNA) expression profile patients evaluate its clinical value. Patients Methods 127 who were diagnosed with 54 age-matched...
AimsCoronavirus disease (COVID-19), also referred to as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is instigated by a novel coronavirus. The was initially reported in Wuhan, China, December 2019. Diabetes risk factor associated with adverse outcomes. Herein, our objective investigate the characteristics of laboratory findings type diabetes mellitus (T2DM) patients infected SARS-CoV-2.MethodsThis retrospective study and included 80 T2DM Jinling Hospital from 2010 2020, well...
There is growing evidence that chemerin, a novel adipokine elevated in obesity and metabolic syndromes, plays crucial role advanced atherosclerosis. This study aimed to determine the chemerin levels diabetes evaluate effects of increased on early A total 245 newly diagnosed diabetic patients 148 age-matched, healthy, normal glucose tolerant (NGT) controls were enrolled. Anthropometric measurements plasma parameters examined, including body mass index (BMI), waist circumference, blood...
Background . p38 mitogen-activated protein kinase (MAPK) plays a crucial role in regulating signaling pathways implicated inflammatory processes leading to diabetic nephropathy (DN). This study aimed examine MAPK activation DN and determine whether beraprost sodium (BPS) ameliorates by inhibiting inflammation pathway rats. Methods Forty male Sprague Dawley (SD) rats were randomly divided into the normal control group, type 2 BPS treatment group. At end of 8-week experiment, we measured renal...
Abstract Aims/Introduction Hypertension is one of the most significant risk factors for diabetes. The present study aimed to investigate associations lipid profiles, including ratio low‐density lipoprotein cholesterol ( LDL ‐C)‐to‐high‐density HDL ‐C) and triglyceride TG ) levels, as well their interactions, with type 2 diabetes in hypertensive patients. Materials Methods Hypertensive patients without a history hypolipidemic agents were enrolled continuously at Clinic, Zhongshan Hospital,...
Type 2 diabetes (T2DM) is a global epidemic and increases mortality due to its vascular complications. Chemerin has been found exert major role in glucose lipid metabolism. The aim of this study was explore the correlation between plasma chemerin levels microangiopathy patients with T2DM. A total 598 T2DM were classified into two groups: without microvascular Anthropometric parameters blood pressure taken. amounts glycosylated hemoglobin, glucose, profiles, creatinine, concentrations...
Time in range (TIR), as a novel metric for glycemic control, has robust relevance with diabetic complications. Diabetic peripheral neuropathy (DPN) is characterized by sudomotor dysfunction.To explore the relationship between TIR obtained from continuous glucose monitoring (CGM) and function detected SUDOSCAN subjects type 2 diabetes.The research enrolled 466 inpatients diabetes. All underwent 3-d CGM SUDOSCAN. was assessed electrochemical skin conductance hands (HESC) feet (FESC). Average...
Abstract P62 is a protein adaptor for various metabolic processes. Mice that lack p62 develop adult-onset obesity. However, investigations on in reproductive dysfunction are rare. In the present study, we explored effect of system. deficiency-induced occurred at young age (8 week old). Young systemic knockout (p62 -/- ) and pituitary-specific flox/flox αGSU cre mice both presented normal state, whereas they displayed infertility phenotypes (attenuated breeding success rates, impaired...
Background: The onset and progression of type 1 diabetes mellitus (T1DM) is closely related to autoimmunity. Effective monitoring the immune system developing targeted therapies are frontier fields in T1DM treatment. Currently, most available tissue that reflects peripheral blood mononuclear cells (PBMCs). Thus, aim this study was identify key PBMC biomarkers T1DM.Methods: Common differentially expressed genes (DEGs) were screened from Gene Expression Omnibus (GEO) datasets GSE9006,...
Polycystic ovary syndrome (PCOS) is characterized by reproductive dysfunctions and metabolic disorders. This study aims to compare the therapeutic effectiveness of glucagon-like peptide-1 receptor agonist (GLP-1RA) + Metformin (Met) versus cyproterone acetate/ethinylestradiol (CPA/EE) Met in overweight PCOS women identify potential proteomic biomarkers disease risk with PCOS.
Beta 2-microglobulin (β2-MG) is a component of the class I major histocompatibility complex (MHCI) and has recently been reported to be involved in type 2 diabetes mellitus (T2DM) cardiovascular disease. However, association β2-MG with left ventricular hypertrophy (LVH) T2DM patients remains unknown. This study aims investigate correlation between serum LVH patients.
Objective . To investigate the effect of ezetimibe on insulin secretion in db/db mice. Methods The diabetic mice aged 8 weeks were randomly assigned into 2 groups and intragastrically treated with or placebo for 6 weeks. age matched db/m served as controls. At end experiment, glucose tolerance test was performed then pancreas collected immunohistochemistry. In addition, vitro perfusion pancreatic islets employed detection first phase. Results group, fasting blood markedly reduced, total...