A5028513698- Hematopoietic Stem Cell Transplantation
- Chemokine receptors and signaling
- Immunotherapy and Immune Responses
- Cancer Cells and Metastasis
- Adipose Tissue and Metabolism
- Immune cells in cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Mesenchymal stem cell research
- Liver physiology and pathology
- Exercise and Physiological Responses
- T-cell and B-cell Immunology
- Circular RNAs in diseases
- Autoimmune and Inflammatory Disorders Research
- Genetics, Aging, and Longevity in Model Organisms
- Lipid metabolism and biosynthesis
- Immune Cell Function and Interaction
- Reproductive System and Pregnancy
- Bone Metabolism and Diseases
- Cancer-related gene regulation
- Platelet Disorders and Treatments
- Ubiquitin and proteasome pathways
- Multiple Myeloma Research and Treatments
- Sirtuins and Resveratrol in Medicine
- Cancer Research and Treatments
- Antimicrobial Peptides and Activities
The University of Texas Southwestern Medical Center
2014-2017
Southwestern Medical Center
2017
Weizmann Institute of Science
2005-2013
The CD45 phosphatase is uniquely expressed by all leukocytes, but its role in regulating hematopoietic progenitors poorly understood. We show that enhanced expression on bone marrow (BM) leukocytes correlates with increased cell motility response to stress signals. Moreover, immature knockout (KO) cells showed defective motility, including reduced homing (both steady state and stromal-derived factor 1) granulocyte colony-stimulating mobilization. These defects were associated adhesion...
Regulation of hematopoietic stem and progenitor cell (HSPC) steady-state egress from the bone marrow (BM) to circulation is poorly understood. While glycogen synthase kinase-3β (GSK3β) known participate in HSPC proliferation, we revealed an unexpected role preferential regulation CXCL12-induced migration murine HSPCs, including long-term repopulating HSCs, over mature leukocytes. egress, regulated by circadian rhythms CXCL12 CXCR4 levels, correlated with dynamic expression GSK3β BM....
Low estrogen states, exemplified by postmenopausal women, are associated with increased adiposity and metabolic dysfunction. We recently reported a paradox, in which conditional receptor-alpha (ERα) mutant mouse shows hyper-metabolic phenotype enhanced brown/beige cell formation ("browning/beiging"). These observations led us to consider that although systemic deficiency of or ERα mice results obesity glucose intolerance at room temperature, cold exposure might induce browning/beiging...