A5018237812- Cholinesterase and Neurodegenerative Diseases
- Alzheimer's disease research and treatments
- Computational Drug Discovery Methods
- Histone Deacetylase Inhibitors Research
- Enzyme Catalysis and Immobilization
- Bioeconomy and Sustainability Development
- Electrochemical sensors and biosensors
- Metabolomics and Mass Spectrometry Studies
- Bioactive natural compounds
- Alkaloids: synthesis and pharmacology
- Sirtuins and Resveratrol in Medicine
- Chemical synthesis and alkaloids
- Microfluidic and Capillary Electrophoresis Applications
- Wnt/β-catenin signaling in development and cancer
- Algal biology and biofuel production
- Phosphodiesterase function and regulation
- Phytochemicals and Antioxidant Activities
- Tea Polyphenols and Effects
- Drug-Induced Hepatotoxicity and Protection
- Consumer Attitudes and Food Labeling
- Heme Oxygenase-1 and Carbon Monoxide
- PI3K/AKT/mTOR signaling in cancer
- Microbial Metabolism and Applications
- Food Quality and Safety Studies
- Pharmaceutical and Antibiotic Environmental Impacts
University of Bologna
2018-2024
Several evidence pointed out the role of epigenetics in Alzheimer's disease (AD) revealing strictly relationships between epigenetic and "classical" AD targets. Based on reported connection among histone deacetylases (HDACs) glycogen synthase kinase 3β (GSK-3β), herein we present discovery biochemical characterization first-in-class hit compound able to exert promising anti-AD effects by modulating targeted proteins low micromolar range concentration. Compound 11 induces an increase...
The self-assembly of amyloid peptides (Aβ), in particular Aβ1-42, into oligomers and fibrils is one the main pathological events related to Alzheimer's disease. Recent studies have demonstrated ability carbon monoxide-releasing molecules (CORMs) protect neurons astrocytes from Aβ1-42 toxicity. In fact, CORMs are able carry release controlled levels CO known exert a wide range anti-inflammatory anti-apoptotic activities at physiologically relevant concentrations. order investigate direct...
Glycogen synthase kinase-3β (GSK-3β) is a multifunctional serine/threonine protein kinase that was originally identified as an enzyme involved in the control of glycogen metabolism. It plays key role diverse physiological processes including metabolism, cell cycle, and gene expression by regulating wide variety well-known substances like synthase, tau-protein, β-catenin. Recent studies have GSK-3β potential therapeutic target Alzheimer´s disease, bipolar disorder, stroke, more than 15 types...
Agri-food by-products, obtained as waste from the food industry, negatively impact global economy and environment. In order to valorize materials fruit juices tomato sauces upcycled rich in health-promoting compounds, they were characterized terms of polyphenolic protein content. The results compared with those collected for their final products. recovery polyphenols was performed via ultrasound-assisted extraction (UAE). A high-performance liquid chromatography–diode array detector...
Microalgae contain many bioactive compounds, which may be exploited in food and nutraceutical fields. Bisphenol A (BPA) is a contaminant microalgae that released from polymeric plastics. Since it responsible for toxic effects on humans, the European legislation set legal BPA limit within foods at 50 µg kg−1 of weight. In this work, fast ultrasounds solid-liquid extraction commercial microalgal powders Chlorella vulgaris, Arthrospira Platensis Scenedesmus sp. was optimized. To increase...
Monacolin K (MK), in red yeast rice (RYR) the forms of lactone (LMK) and hydroxy acid (AMK), is known for its anti-hypercholesterolemic activity. Under rising demand natural bioactive molecules, we present a green ultrasound-assisted extraction (UAE) optimization study MK RYR. The development validation fast, sensitive, selective, reproducible, accurate ultra-high-performance liquid chromatography (UHPLC) method coupled to diode array detection LMK AMK allowed us evaluate recovery different...
With the aim of developing an in vitro model for bioavailability (BA) prediction drugs, we focused on study levonorgestrel (LVN) released by 1.5 mg generic and brand-name tablets. The developed method consisted combining a standard dissolution test with optimized parallel artificial membrane permeability assay (PAMPA) to gain insights into both drug release gastrointestinal absorption. Interestingly, obtained results revealed that tablet test, combined PAMPA, highlighted significant decrease...