Herein, we have reported the highly effective use of Knoevenagel condensation reaction to synthesize organoselenium containing quinoline-based probe. The probe was characterized by Nuclear Magnetic Resonance and Infra-Red spectroscopy mass spectrometry. selectively detects KO 2 with high sensitivity over other reactive oxygen species biothiols. Photo-induced electron transfer process is responsible for fluorescence “ turn-on” event through transformation selenide selenoxide. reacted in less...

•NO2 generated from •NO and air add to iron(III) porphyrin upon nitration, which isomerized spontaneously hydrolysis, yielding a meso-hydroxylated cation that seized by the end oxidation product, nitrate ion, through extensive hydrogen bonding.

The iron complexes of 5,10,15-tris(4-nitrophenyl)corrole have been prepared and characterized by various spectroscopic techniques. (nitrosyl)iron complex is diamagnetic its X-ray structure reveals an almost perfectly linear Fe–N–O bond. EPR spectroscopy in conjunction with 15 N labelling were used to deduce the redox centre one-electron reduction oxidation products corrole.

The synthesis and characterization of manganese complexes 5,10,15-tris(4-nitrophenyl) corrole in different oxidation states are described. Adoption established protocols for the (nitrido)manganese(V) led to expected derivative as a minor product, accompanied by nitrogen atom insertion into macrocycle. major product was fully characterized via combination spectroscopy X-ray crystallography 6-azahemiporphycene.

A series of novel carbazole based α-aminophosphonate derivatives were synthesized under solvent-free condition, characterized and evaluated for their cholinesterase inhibition, enzyme kinetic in-vitro cell viability using N2a cells, neuroprotective studies against H2O2-induced stress cells antioxidant DPPH radical activity. Test compounds displayed better AChE activity (0.475 to 7.781 µM) than BuChE (3.306 21.32 µM). Compound 4j was most potent derivative as well with IC50=0.475 ± 0.12 µM...

Synthesis of the first selenium containing quinoline probe, selective for superoxide detection via “turn-on” fluorescence response. The probe exhibited better anticancer activity than cisplatin.

Herein, a series of novel antipyrine based α-aminophosphonates derivatives were synthesized and characterized. The subjected for in vitro cholinesterase inhibition, enzyme kinetic studies, protein denaturation assay, proteinase inhibitory assay cell viability assay. For the results inferred that test compounds possess better AChE activity (0.46 to 6.67 µM) than BuChE (2.395 12.47 µM). Compound 4j inhibited both (IC50 = 0.475 ± 0.12 µM 2.95 0.16 µM, respectively), implying it serves as dual...

Herein, we have reported the highly effective use of Knoevenagel condensation reaction to synthesize organoselenium containing quinoline-based probe. The probe was characterized by Nuclear Magnetic Resonance and Infra-Red spectroscopy mass spectrometry. selectively detects KO2 with high sensitivity over other reactive oxygen species biothiols. Photo-induced electron transfer process is responsible for fluorescence “turn-on” event through transformation selenide selenoxide. reacted in less...

<title>Abstract</title> Microspheres is novel drug delivery system for improving therapeutic action of drug, increasing prolong action, lowering dose frequency dosage form and to improve patient complies. are reducing oral administration side effect such as gastric irritation in stomach. Glibenclamide microspheres were developed by ionotropic gelation method using sodium alginate chitosan. Calcium chloride was used a cross linking agent. Prepared evaluated entrapment efficiency, microsphere...

Microspheres is novel drug delivery system for improving therapeutic action of drug, increasing prolong action, lowering dose frequency dosage form and to improve patient complies. are reducing oral administration side effect such as gastric irritation in stomach. Glibenclamide microspheres were developed by ionotropic gelation method using sodium alginate chitosan. Calcium chloride was used a cross linking agent. Prepared evaluated entrapment efficiency, microsphere size, morphology, FTIR,...

The unavailability of recommended viral transport medium during epidemics respiratory infections is a substantial healthcare concern. It may prompt the use alternatives, which give rise to results with questionable validity. present study was carried out assess and validate utility commonly available solvents in hospital/healthcare set-ups be used as ready economical alternatives commercial VTMs. To evaluate readily an alternative VTM, cell culture supernatant pH1N1 2009 isolate HA titres...

Background: Binding of such proteins with a developing fibrin mesh or to the extracellular matrix has ability create chemotactic gradients aiding recruitment stem cells, thereby, stimulating cell migration and differentiation this may promotes repair regeneration. There is unique concept in platelet concentrates called platelet-rich (PRFM) which processed using higher attraction without utilization bovine thrombin. Aim Objectives: The aim study evaluate antibacterial antifungal effects (PRF)...

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