A5071495604- Advanced Electron Microscopy Techniques and Applications
- Social Media and Politics
- Public Relations and Crisis Communication
- Advanced X-ray Imaging Techniques
- Middle East and Rwanda Conflicts
- Media Studies and Communication
- Socioeconomic Development in MENA
- DNA and Nucleic Acid Chemistry
- Enzyme Structure and Function
- Photosynthetic Processes and Mechanisms
- Spectroscopy and Quantum Chemical Studies
- Jewish and Middle Eastern Studies
- Islamic Studies and History
- Middle East Politics and Society
- Pregnancy and preeclampsia studies
- Protein Structure and Dynamics
- Technology Adoption and User Behaviour
- E-Government and Public Services
- Electron and X-Ray Spectroscopy Techniques
- RNA and protein synthesis mechanisms
- Public Spaces through Art
- Advanced Fluorescence Microscopy Techniques
- Force Microscopy Techniques and Applications
- Advanced Image and Video Retrieval Techniques
- Humor Studies and Applications
Gulf University for Science & Technology
2014-2025
University of Wisconsin–Milwaukee
2013-2023
University of British Columbia
2009
Kuwait University
2009
King's College London
2007
Al-Sabah Hospital
2000
University of Southern California
1995
Significance Many functions in the cell are performed by Brownian machines, macromolecular assemblies that use energy from thermal environment for many of conformational changes involved their work cycles. Here we present a new approach capable mapping continuous motions such nanomachines along trajectories free-energy landscape and demonstrate this capability context experimental cryogenic electron microscope snapshots ribosome, nanomachine responsible protein synthesis all living...
Abstract A primary reason for the intense interest in structural biology is fact that knowledge of structure can elucidate macromolecular functions living organisms. Sustained effort has resulted an impressive arsenal tools determining static structures. But under physiological conditions, macromolecules undergo continuous conformational changes, a subset which are functionally important. Techniques capturing changes underlying function essential further progress. Here, we present...
Preterm birth is a major global health challenge, the leading cause of death in children under 5 years age, and key measure population's general nutritional status. Current clinical methods estimating fetal gestational age are often inaccurate. For example, between 20 30 weeks gestation, width 95% prediction interval around actual estimated to be 18-36 days, even when best ultrasound estimates used. The aims this study improve provide personalised predictions future growth.Using...
This study uses diffusion of innovations theory to examine the influence Muslim religious scholars on internet in Saudi Arabia. It applies content analysis fatwa, edicts that issue, explore fatwa decisions relating since its launch Arabia 1999. There are 34 total, 11 with approving decisions, disapproving ones, and 12 conditionally decisions. Those who issue argue it helps spread word Allah if Muslims do not exploit opportunities provided by internet, then non-Muslims non-believers will use...
Abstract The Third Person Effect ( tpe ) hypothesis postulates that individuals are likely to estimate negative news media will have greater effects on others than themselves. This study uses explore whether an individual’s religious predispositions and use of influences the impact coverage their perceptions Islam. Furthermore, it tests predispositions, media, influence a person’s support for censorship researchers constructed two different scenarios in which differential estimates were used...
The responses of 1,443 individuals to a questionnaire were used test cognitive-decision mediation model that predicts the expression an opinion. Fear Social Isolation and opinion congruence predicted media surveillance motive was mediated by attention, interpersonal discussions, elaboration. In turn, perceived familiarity with issue mainly perspective diversity structural knowledge Also, information instrumentality (the usefulness information) diversity, whereas presenting counter-arguments...
This study aims to analyze the comments of news readers on related electronic websites concerning topics published in newspapers from Gulf Arab countries and another state. The research problem is linked social movement Bahrain during 2011, which led significant variation opinions comments. method followed a content analysis 124 articles appearing first page Al Watan, Riyadh, Al-Ahram online newspapers, their reporting Bahrain’s these comprised 30 items 20 19 totalling 1,929 individual...
The advent of the X-ray free-electron laser (XFEL) has made it possible to record diffraction snapshots biological entities injected into beam before onset radiation damage. Algorithmic means must then be used determine snapshot orientations and thence three-dimensional structure object. Existing Bayesian approaches are limited in reconstruction resolution typically 1/10 object diameter, with computational expense increasing as eighth power ratio diameter resolution. We present an approach...
Recent approaches to the study of biological molecules employ manifold learning single-particle cryo-EM data sets map continuum states a molecule into low-dimensional space spanned by eigenvectors or "conformational coordinates". This is done separately for each projection direction (PD) on an angular grid. One important step in deriving consolidated occupancies, from which free energy landscape can be derived, propagate conformational coordinates given choice "anchor PD" across entire...
In this paper, we describe a new brute force algorithm for building the -Nearest Neighbor Graph (k-NNG). The k-NNG has many applications in areas such as machine learning, bio-informatics, and clustering analysis. While there are very efficient algorithms data of low dimensions, high dimensional search is best algorithm. There two main parts to algorithm: first part finding distances between input vectors, which may be formulated matrix multiplication problem; second selection k-NNs each...
Mobile learning (ML) technology and its services have provided a new platform for higher education institutions to enhance the process. provides learners with flexibility ubiquity. However, students' satisfaction factors of using ML in private public universities remain academically unexplored. In this study, constructivism theory was applied investigate that predict use among university students The researchers developed questionnaire 43 items gather information about degree mobile college...
This paper presents an implementation of the brute-force exact k-Nearest Neighbor Graph (k-NNG) construction for ultra-large high-dimensional data cloud. The proposed method uses Graphics Processing Units (GPUs) and is scalable with multi-levels parallelism (between nodes a cluster, between different GPUs on single node, within GPU). applicable to homogeneous computing clusters varying number per node. We achieve 6-fold speedup in processing as compared optimized running cluster CPUs bring...
Single-particle structure recovery without crystals or radiation damage is a revolutionary possibility offered by X-ray free-electron lasers, but it involves formidable experimental and data-analytical challenges. Many of these difficulties were encountered during the development cryogenic electron microscopy biological systems. Electron entities has now reached spatial resolution about 0.3 nm, with rapidly emerging capability to map discrete continuous conformational changes energy...
Abstract We present a new approach to determining the conformational changes associated with biological function, and demonstrate its capabilities in context of experimental single-particle cryo-EM snapshots ryanodine receptor (RyR1), Ca 2+ -channel involved skeletal muscle excitation/contraction coupling. These results include detailed motions functional paths including transitions between energy landscapes. The differ substantially from those inferred discrete structures, shedding light on...
Objective. The aim of the study: To evaluate correlations betweenZn2+, Cu2+, Mg2+, Se2+ and Cr3+ alteration in T cell subsetsduring diabetic normal pregnancy. Methods. study involved63 women with gestational diabetes mellitus (GD) 16 pregnantwomen Type 2 48 healthy, non-pregnant womenwere included as controls. Ten ml whole venous blood from eachparticipant was analyzed for electrolytes by atomic absorption; totalantioxidant activity, individual enzymatic antioxidants spectrophotometry;and...
After many decades of heavily relying on local newspapers and controlled radio TV, Kuwaitis switched to the Internet obtain information, news political analysis. The dispute power after death Kuwaiti Emir Sheik Jaber Al-Ahmad Al-Sabah 15 January 2006, followed by parliament's demands change electoral constituencies voting system National Assembly in May forced go online get latest analysis regarding two disputes. journalism created an public sphere discuss issues that were banned locally...
Abstract Using experimental single-particle cryo-EM snapshots of ryanodine receptor (RyR1), a Ca 2+ -channel involved in skeletal muscle excitation/contraction coupling, we present quantitative free-energy landscapes, reaction coordinates, and three-dimensional movies the continuous conformational changes associated with binding activating ligands. Our results show multiple routes to ligand comparable branching ratios. All high-probability involve significant before after We also new...