A5071856151- Vector-borne infectious diseases
- Plant Pathogenic Bacteria Studies
- Leptospirosis research and findings
- Insect symbiosis and bacterial influences
- Aquaculture disease management and microbiota
- Burkholderia infections and melioidosis
- Parasites and Host Interactions
- Viral Infections and Immunology Research
- Immune cells in cancer
- Toxin Mechanisms and Immunotoxins
- Mycobacterium research and diagnosis
- Parasitic Infections and Diagnostics
- Microbial infections and disease research
- Escherichia coli research studies
- Chemical Looping and Thermochemical Processes
- Immune responses and vaccinations
- Immune Response and Inflammation
- Gut microbiota and health
- Invertebrate Immune Response Mechanisms
The University of Texas Medical Branch at Galveston
2020-2023
Brigham Young University
2016
The Burkholderia pseudomallei complex classically consisted of B. mallei, pseudomallei, and thailandensis, but has now expanded to include oklahomensis, humptydooensis, three unassigned clades. Methods for detecting differentiating the been topic recent research due phenotypic genotypic similarities these species. mallei are recognized as CDC Tier 1 select agents, causative agents glanders melioidosis, respectively. Although thailandensis oklahomensis generally avirulent, both display...
The intracellular bacterium Orientia tsutsugamushi (Ot) is the causative agent of scrub typhus, an emerging and neglected tropical disease. Immunity against Ot infection in patients known to be short-lived, as circulating antibodies can wane around one-year post-infection. However, its underlying mechanisms remain unclear; host immune signatures clinically prevalent strains are also undefined. In this study, we infected C57BL/6 mice with two distinct virulence examine splenic B cell germinal...
Orientia tsutsugamushi is an obligately intracellular bacterium with endothelial tropism and can cause mild to lethal scrub typhus in humans. No vaccine available for this reemerging severely neglected infection. Previous studies have utilized inbred mice, yet such models intrinsic limitations. Thus, the development of suitable mouse that better mimic human diseases great need immunologic investigation future studies. This study aimed at establishing outbred CD-1 mice defining immune...
Scrub typhus is a leading cause of febrile illness in endemic countries due to infection with Orientia tsutsugamushi (Ot), seriously understudied intracellular bacterium. Pulmonary involvement associated vascular parasitism patients common and can develop into life threatening interstitial pneumonia. The diverse antigenicity Ot genotypes inter-strain differences genome content are connected varied virulence clinical outcomes; however, detailed studies strain-related pulmonary immune...
Scrub typhus is a life-threatening zoonosis caused by the obligate intracellular bacterium Orientia tsutsugamushi ( Ot ) that transmitted infected larvae of trombiculid mites. However, mechanism which disseminates from bite site to visceral organs remains unclear; host innate immunity against bacterial dissemination and replication during early infection poorly understood. In this study, using an intradermal mouse model fluorescent probe-labeled , we assessed dynamic pattern immune cell...
Abstract Burkholderia pseudomallei ( Bpm ) is a bacterial pathogen that causes Melioidosis, disease with up to 40% mortality and an infection relapse of 15–23% despite antibiotic treatment. Ineffective clearance by antibiotics believed be due persistence, hibernation-like survival mechanism modulated, in part, toxin–antitoxin systems (TAS). Several organisms possess repertoire TASs but defining environmental cues eliciting their activity hindered laborious vitro experiments, especially when...
Abstract Orientia tsutsugamushi is an obligately intracellular bacterium with endothelial tropism and can cause mild to lethal scrub typhus in humans. No vaccine available for this reemerging severely neglected infection. Previous studies have utilized inbred mice, yet such models intrinsic limitations. Thus, the development of suitable mouse that better mimic human diseases great need immunologic investigation future studies. This study aimed at establishing outbred CD-1 mice defining...
Abstract Scrub typhus is the leading source of febrile illness in endemic countries due to infection with Orientia tsutsugamushi ( Ot ), a seriously understudied intracellular bacterium. Pulmonary complications patients are common and can develop into life threatening conditions. The diverse antigenicity genotypes inter-strain differences seem be connected varied virulence clinical outcomes; however, detailed studies strain-related pulmonary immune responses human or experimental animals...
Abstract Scrub typhus is a poorly studied, but life-threatening, disease caused by the bacterium Orientia tsutsugamushi (Ot). Humoral immunity in scrub patients wanes as early one-year post-infection; yet its underlying mechanisms remain unclear. The objective of this study to delineate humoral immune dysregulation and B cell dysfunction during acute Ot infection. Using lethal C57BL/6 murine model, we evaluated splenic GC responses immunofluorescent staining. Splenic germinal centers (GL-7...