About
Contact & Profiles
A5021599663
Research Areas
- Liver Diseases and Immunity
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Cytokine Signaling Pathways and Interactions
University of Minnesota
2022
Here, we report that the LynB splice variant of Src-family kinase Lyn exerts a dominant immunosuppressive function in vivo, whereas LynA isoform is uniquely required to restrain autoimmunity female mice. We used CRISPR-Cas9 gene editing constrain lyn splicing and expression, generating single-isoform knockout (LynA KO ) or Autoimmune disease total mice characterized by production antinuclear antibodies, glomerulonephritis, impaired B cell development, overabundance activated cells...
10.1126/sciadv.abj5227
article
EN
cc-by-nc
Science Advances
2022-04-22
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