A5036532674- Bone health and treatments
- Metabolism and Genetic Disorders
- Neonatal Respiratory Health Research
- Vitamin D Research Studies
- Alkaline Phosphatase Research Studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Parathyroid Disorders and Treatments
- Connective tissue disorders research
- Sexual Differentiation and Disorders
- Infant Nutrition and Health
- Thyroid and Parathyroid Surgery
- Genetics and Neurodevelopmental Disorders
- Congenital heart defects research
- Child and Adolescent Health
- Diet and metabolism studies
- Electrolyte and hormonal disorders
- Medical Imaging and Pathology Studies
- Acute Myocardial Infarction Research
- Bone and Dental Protein Studies
- Heterotopic Ossification and Related Conditions
- Medical Research and Practices
- Adrenal and Paraganglionic Tumors
- Bone Metabolism and Diseases
- Birth, Development, and Health
- Biomedical Research and Pathophysiology
Royal Manchester Children's Hospital
2016-2024
University of Manchester
2019-2023
Manchester Academic Health Science Centre
2020-2023
Manchester University NHS Foundation Trust
2022
University of Liverpool
2021
Royal Liverpool University Hospital
2021
McGill University
2021
Shriners Hospitals for Children - Canada
2021
Imperial College London
2021
University of Helsinki
2021
Increased endogenous neurogenesis has a significant regenerative role in many experimental models of cerebrovascular diseases, but there have been very few studies humans. We therefore examined whether was evidence altered an 84-year-old patient who suffered accident 1 week prior to death. Using antibodies that specifically label neural stem/neural progenitor cells, we the presence immunopositive cells around and distant from infarcted area, compared this with control, age-matched...
This study aimed to identify current trends in the management of metabolic bone disease prematurity (MBDP) United Kingdom.
Hypoparathyroidism is characterised by hypocalcaemia, and standard management with an active vitamin D analogue adequate oral calcium intake (dietary and/or supplements). Little described in the literature about impact of intercurrent illnesses on homeostasis children hypoparathyroidism.We describe three hypoparathyroidism whom led to hypocalcaemia escalation treatment alfacalcidol (1-hydroxycholecalciferol) supplements.Three infants managed for (two homozygous mutations GCMB2 gene one...
Zoledronic acid (ZA), used for treatment of children with osteoporosis, can cause acute phase reaction (APR) following the first infusion. Many institutions have a policy to admit and monitor all their ZA
Hypokalaemia at presentation of diabetic ketoacidosis is uncommon as insulin deficiency and metabolic acidosis shifts potassium extracellularly. However, hypokalaemia a recognised complication the management administration correction intracellularly. We describe case 9-year-old girl with newly diagnosed type 1 diabetes mellitus presenting in ketoacidosis, severe due to prolonged emesis. After commencing for her serum sodium osmolality increased rapidly. despite maximal concentrations running...
Congenital hyperinsulinism (CHI) is the commonest cause of persistent and severe hypoglycemia in infancy due to unregulated insulin secretion from pancreatic β-cells. Prompt early diagnosis important, as reduces glucose supply brain, resulting significant brain injury risk death. Histologically, CHI has focal diffuse forms; CHI, an inappropriate level secreted localized β-cell hyperplasia. We report a 4-month-old male infant, who presented with sudden illness collapse without recognized...
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
Summary Congenital hyperinsulinism (CHI) is an important cause of severe hypoglycaemia in infancy. To correct hypoglycaemia, high concentrations dextrose are often required through a central venous catheter (CVC) with consequent risk thrombosis. We describe series six cases CHI due to varying aetiologies from our centre requiring CVC for the management who developed thrombosis association CVC. subsequently analysed incidence and factors CVC-associated thrombosis, as well outcomes enoxaparin...
<b><i>Introduction:</i></b> Hypophosphatasia is a systemic bone disease characterized by inhibition of mineralization due to mutations in the <i>ALPL</i> gene that results deficiency tissue nonspecific alkaline phosphatase. The perinatal form most severe. In past, this was lethal, although human recombinant enzyme replacement therapy has now been developed and licensed, which improves survival. Perinatal hypophosphatasia usually suggested on antenatal...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
<h3>Background</h3> The National Institute of Clinical Excellence (NICE) Guideline on Intrapartum care (2007) advises the duration and type observations needed neonates delivered in meconium-stained liquor. <h3>Aim</h3> This audit investigated current practice for postnatal meconium maternity units Kent, Surrey Sussex (KSS). NICE guidance was used as gold standard comparison. <h3>Method</h3> All KSS were contacted their local protocol obtained. <h3>Results</h3> 19 responded. 10/19 (53%) did...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)