A5088469628- Cell Image Analysis Techniques
- Image Processing Techniques and Applications
- Single-cell and spatial transcriptomics
- Advanced Electron Microscopy Techniques and Applications
- Advanced Fluorescence Microscopy Techniques
- Viral Infectious Diseases and Gene Expression in Insects
- CAR-T cell therapy research
AstraZeneca (United Kingdom)
2022-2023
PROteolysis TArgeting Chimeras (PROTACs) use the ubiquitin–proteasome system to degrade a protein of interest for therapeutic benefit. Advances made in targeted degradation technology have been remarkable, with several molecules having moved into clinical studies. However, robust routes assess and better understand safety risks PROTACs need be identified, which is an essential step toward delivering efficacious safe compounds patients. In this work, we used Cell Painting, unbiased...
Abstract In image-based profiling, software extracts thousands of morphological features cells from multi-channel fluorescence microscopy images, yielding single-cell profiles that can be used for basic research and drug discovery. Powerful applications have been proven, including clustering chemical genetic perturbations based on their similar impact, identifying disease phenotypes by observing differences in between healthy diseased cells, predicting assay outcomes using machine learning,...
Summary PROTACs (PROteolysis TArgeting Chimeras) use the ubiquitin-proteasome system to degrade a protein of interest for therapeutic benefit. Advances in targeted degradation technology have been remarkable with several molecules moving into clinical studies. However, robust routes assess and better understand safety risks need be identified, which is an essential step towards delivering efficacious safe compounds patients. In this work, we used Cell Painting, unbiased high content imaging...