A5005560150- Biochemical and Molecular Research
- Click Chemistry and Applications
- HIV/AIDS drug development and treatment
- Antimicrobial agents and applications
- Phenothiazines and Benzothiazines Synthesis and Activities
- RNA modifications and cancer
- Synthesis and biological activity
- Adenosine and Purinergic Signaling
Technische Universität Braunschweig
2021-2023
The growing demand for 4′-modified nucleoside analogs in medicinal and biological chemistry is contrasted by the challenging synthetic access to these molecules lack of efficient diversification strategies. Herein, we report development a biocatalytic approach based on phosphorylases, which allows straightforward installation variety pyrimidine purine nucleobases 4′-alkylated sugar scaffold. Following identification suitable biocatalyst as well its characterization with kinetic experiments...
The 6,7-dihydroxycoumarin-5-carboxylates DHCou and 4-Me-DHCou have been synthesized via five-step route including a propargyl-Claisen rearrangement as key step. compounds show antibiofilm activity against Stapylococcus aureus Candida albicans but lack the cytotoxic of parent 6,7-dihydroxycoumarines such esculetin 4-methylesculetin.
The growing demand for 4'-modified nucleoside analogs in medicinal and biological chemistry is contrasted by the challenging synthetic access to these molecules lack of efficient diversification strategies. Herein, we report development a biocatalytic approach based on phosphorylases, which allows straightforward installation variety pyrimidine purine nucleobases 4'-alkylated sugar scaffold. Following identification suitable biocatalyst as well its characterization with kinetic experiments...
The growing demand for 4'-modified nucleoside analogs in medicinal and biological chemistry is contrasted by the challenging synthetic access to these molecules lack of efficient diversification strategies. Herein, we report development a biocatalytic approach based on phosphorylases, which allows straightforward installation variety pyrimidine purine nucleobases 4'-alkylated sugar scaffold. Following identification suitable biocatalyst as well its characterization with kinetic experiments...