A5004953375- Chronic Lymphocytic Leukemia Research
- Infectious Diseases and Tuberculosis
- Parasitic infections in humans and animals
- Oral and Maxillofacial Pathology
- Gallbladder and Bile Duct Disorders
- Congenital Anomalies and Fetal Surgery
- Bone Tumor Diagnosis and Treatments
- Hernia repair and management
- Appendicitis Diagnosis and Management
- Sarcoma Diagnosis and Treatment
- Tumors and Oncological Cases
- Amoebic Infections and Treatments
- Glycosylation and Glycoproteins Research
- Biliary and Gastrointestinal Fistulas
- Gastrointestinal disorders and treatments
- Lymphoma Diagnosis and Treatment
- Pediatric Hepatobiliary Diseases and Treatments
- Diagnosis and treatment of tuberculosis
- Immunotherapy and Immune Responses
- Intestinal Malrotation and Obstruction Disorders
- Cerebrospinal fluid and hydrocephalus
- Hematological disorders and diagnostics
- SARS-CoV-2 and COVID-19 Research
- Galectins and Cancer Biology
- Pancreatitis Pathology and Treatment
Maharishi Markandeshwar University, Mullana
2015-2025
All India Institute of Medical Sciences Rishikesh
2025
Institute of Medical Sciences
2014-2024
Graphic Era University
2024
Mayo Clinic
2024
Temple University Hospital
2024
Chitkara University
2023
Amity University
2021
Thermo Fisher Scientific (United States)
2021
The University of Sydney
2021
Abstract B-cell chronic lymphocytic leukemia (B-CLL) is characterized by an accumulation of neoplastic B cells due to their resistance apoptosis and increased survival. Among various factors, the tumor microenvironment known play a role in regulation cell proliferation survival many cancers. However, it remains unclear how contributes B-CLL cells. Therefore, we studied influence bone marrow stromal cell–induced hedgehog (Hh) signaling on Our results show that Hh inhibitor, cyclopamine,...
We present the case of a 50-year-old man with large swelling on left side his face. He was diagnosed intramuscular cysticercosis in masseter muscle surrounding phlegmon high-resolution ultrasound and managed conservatively.
Chronic lymphocytic leukemia (CLL) cells survive longer in vivo than vitro, suggesting that the tissue microenvironment provides prosurvival signals to tumor cells. Primary and secondary lymphoid tissues are involved pathogenesis of CLL, role these microenvironments has not been explored completely. To elucidate host-tumor interactions, we performed gene expression profiling (GEP) purified CLL from peripheral blood (PB; n = 20), bone marrow (BM; 18), lymph node (LN; 15) validated key pathway...
The ongoing Corona virus (COVID-19) pandemic has witnessed global political responses of unimaginable proportions. Many nations have implemented lockdowns that involve mandating citizens not to leave their residences for non-essential work. Indian government taken appropriate and commendable steps curtail the community spread COVID-19. While this may be extremely beneficial, perspective discusses other reasons why COVID-19 a lesser impact on India. We analyze current pattern SARS-CoV-2...
A portable, low-cost, efficient, disposable, and simple nanosensor for point-of-care or on-site monitoring of vitamin B12 remains a challenge quality control in the food, beverage, pharmaceutical industries. solid-state fluorescence probe based on N-, K-, Ca-doped carbon quantum dots (CQDs) embedded bioplastic nanocomposite quantitative detection with good sensitivity accuracy is demonstrated here. wide range morphological, physiochemical, compositional, crystallinity, functional groups have...
Introduction White matter tracts in the brain are essential for neurocognitive processes. Understanding their integrity is crucial assessing both healthy and pathological states. Tractography based on diffusion tensor imaging (DTI) provides a non-invasive method to map measure these pathways. The purpose of this study examine 10 main white females aged 18 50, focusing mean diffusivity (MD), volume, fractional anisotropy (FA). Materials methods Fifty-one 18-50 years participated study,...
Abstract Purpose: In B-cell chronic lymphocytic leukemia (CLL), high CD38 expression has been associated with unfavorable clinical course, advanced disease, resistance to therapy, shorter time first treatment, and survival. However, the genes CLL patient subgroups low their potential role in disease progression is not known. Experimental Design: To identify disparity patients versus expression, transcriptional profiles were obtained from cells 39 different using oligonucleotide microarray....
Earlier, we reported that CTLA4 expression is inversely correlated with CD38 in chronic lymphocytic leukemia (CLL) cells. However, the specific role of CLL pathogenesis remains unknown. Therefore, to elucidate possible pathogenesis, was down-regulated primary We then evaluated proliferation/survival these cells using MTT, 3H-thymidine uptake and Annexin-V apoptosis assays. also measured levels downstream molecules involved B-cell signaling including STAT1, NFATC2, c-Fos, c-Myc, Bcl-2...
The incidence of tuberculosis (TB) is increasing worldwide and so are its consequences. Its oral manifestations infrequent, occurring in approximately 3% all cases. Although the primary lesion occurs as a pulmonary infection, extrapulmonary infections have also shown an increase over past few years. These generally involve head neck through haematogenous or lymphatic routes. clinical presentation may be ulcer, granuloma, orofacial TB, TB salivary glands tuberculous lymphadenitis. Rarely,...
Background. This study presents a comparative analysis of recently published guidelines to manage cutaneous squamous cell carcinoma (cSCC) and basal (cBCC) within the United States (US). Methods. A PubMed database search was performed for time period between June 1, 2016, December 2022. comprehensive comparison in following clinical interest areas: staging risk stratification, management primary tumor regional nodes with curative intent, palliative treatment. Results. Guidelines from 3...
Emerging evidence indicates that the tumour microenvironment (TME) regulates behaviour of chronic lymphocytic leukaemia (CLL). However, precise mechanism and molecules involved in this process remain unknown. Gene expression profiles CLL cells from lymph node (LN), bone marrow (BM) peripheral blood (PB) indicate overexpression a tolerogenic signature nodes (LN-CLL). Based on their role B cell biology, progression CLL, or immune regulation, few genes 83-gene were selected for further...
Laparoscopy is widely practiced and offers realistic benefits over conventional surgery. Port closure important after a laparoscopic procedure to prevent port site incisional hernia. Larger size increasing numbers of ports needed perform more complex procedures are likely increase the incidence hernias (PSHs). PSHs tend develop frequently at umbilical midline sites due thinness skin weaknesses in linea alba. More than 90% occur through 10 mm large can 5 also. The aim was study outcomes...
In B-cell chronic lymphocytic leukemia (CLL), Rai stage, immunoglobulin gene mutational status, chromosomal abnormalities, CD38 and ZAP-70 expression were used as prognostic markers. this study, to understand the molecular basis of abnormalities leading tumor progression, 90 CLL patients grouped into poor prognosis (with 11q deletion trisomy 12) good normal karyotype 13q deletion) their clinical outcome was assessed. Gene profiles 35 samples with (11q deletion, n=9; 12, n=5) (13q n=13;...
Annular pancreas is a developmental anomaly that can be associated with other conditions such as Down syndrome, duodenal atresia, and Hirschsprung disease. A band of pancreatic tissue, in continuity the head, completely or incompletely encircles descending duodenum, sometimes assuming "crocodile jaw" configuration. We present case an adult who presented epigastric pain vomiting was found to have annular pancreas.
India has witnessed a high number of COVID-19 cases, but mortality been quite low, and most cases have asymptomatic or mild. In early April, we had hypothesized low in India, based on the concept cross-immunity. The presence cross-immunity is presumed to lead milder course disease allow time necessary for development adaptive immunity by body eliminate virus. Evidence supporting our hypothesis started showing up. Multiple studies shown generation different T cell subsets B cells responding...