A5101450208- Angiogenesis and VEGF in Cancer
- Cerebrovascular and Carotid Artery Diseases
- Cancer, Lipids, and Metabolism
- Cardiovascular Health and Disease Prevention
- Nicotinic Acetylcholine Receptors Study
- Plant Gene Expression Analysis
- Chromosomal and Genetic Variations
- Advances in Cucurbitaceae Research
- Retinal Diseases and Treatments
- Genomics and Phylogenetic Studies
- Extracellular vesicles in disease
- Circular RNAs in diseases
- Chemokine receptors and signaling
- Protease and Inhibitor Mechanisms
- Antiplatelet Therapy and Cardiovascular Diseases
- Genetic diversity and population structure
- Nerve injury and regeneration
- Plant-Microbe Interactions and Immunity
- Signaling Pathways in Disease
- Intracranial Aneurysms: Treatment and Complications
- Apelin-related biomedical research
- Cardiac and Coronary Surgery Techniques
- Photosynthetic Processes and Mechanisms
- Calcium signaling and nucleotide metabolism
- Plant nutrient uptake and metabolism
Sir Run Run Shaw Hospital
2023-2025
Zhejiang University
2023-2025
Yangzhou University
2023-2024
Anhui Agricultural University
2024
Sun Yat-sen University
2011-2023
The First Affiliated Hospital, Sun Yat-sen University
2011-2023
Peking University
2023
Peking University Third Hospital
2023
Yantai University
2023
First Affiliated Hospital of Guangdong Pharmaceutical University
2021-2022
Hypertension is characterized by endothelial dysfunction and arterial stiffness, which contribute to the pathogenesis of atherosclerotic cardiovascular diseases. Nicotinamide adenine dinucleotide (NAD+) an indispensable cofactor in all living cells that involved fundamental biological processes. However, hypertensive patients, alterations NAD+ levels their relation with blood pressure (BP) elevation vascular damage have not yet been studied. Here we reported patients exhibited lower levels,...
Abstract Background Targeting oncogenic histone modification by deacetylase inhibitors (HDACis) demonstrates promising prospects in clinical cancer treatment, whereas a notable proportion of patients cannot benefit from HDACi therapy. This study aims to explore how influences the tumor microenvironment, order identify potential targets for reversing resistance therapies. Methods Macrophage infiltration was compared between HDACi-responding and HDACi-nonresponding patients. The impact HDACis...
Hypertensive patients exhibit decline in capillary density and endothelial progenitor cells (EPCs). However, whether rarefaction hypertension is associated with defect angiogenesis of EPCs remains unknown. We hypothesized that impaired mitochondrial function late the structural lack microcirculation via deficient CXCR4/JAK2/SIRT5 signaling.We performed detection hypertensive healthy subjects. Angiogenic capacity circulating were evaluated. The underlying mechanisms further investigated by...
Atlantic giant (AG, Cucurbita maxima) is a type of pumpkin in the Cucurbitaceae family and has world's largest fruit. AG possesses excellent ornamental economic value due to its well-known large However, pumpkins are usually thrown away after viewing, thus generating waste resources. To explore additional pumpkins, metabolome assay was performed between Hubbard (a small fruit pumpkin) fruits. We found that bioactive compounds, especially flavonoids (including 8-prenylnaringenin,...
Patients with coronary artery disease (CAD) are characterized by a decline in vascular regeneration, which is related to the dysfunction of endothelial progenitor cells (EPCs). G-protein-coupled receptor 4 (GPR4) proton-sensing (GPCR) that contributes neovascularization acidic microenvironments. However, role GPR4 regulating angiogenic capacity EPCs from CAD patients response acidity generated ischemic tissue remains completely unclear.The collected and healthy subjects was evaluated...
A major challenge to treat vascular endothelial injury is the restoration of endothelium integrity in which progenitor cells (EPCs) plays a central role. Transplantation EPCs as promising therapeutic means subject two interrelated processes, homing and differentiation vivo, thus lack either one may greatly affect outcome EPC-based therapy. Herein, polymeric nanocarrier applied for codelivery CXCR4 VEGFa genes simultaneously promote migration EPCs. Moreover, MRI T2 contrast agent SPION NIR...
Introduction: The effectiveness and safety of vedolizumab (VDZ) against ulcerative colitis (UC) have been validated in several randomized controlled trials real-world studies Western countries. However, there are few on VDZ Asia, the follow-up period for these is generally short. Therefore, this study evaluates long-term Chinese patients with UC. Methods: This retrospective included moderate to severe UC treated between September 2019 April 2022 at Sir Run Shaw Hospital, College Medicine...
WD40 proteins, a super gene family in eukaryotes, are involved multiple biological processes. Members of this have been identified several plants and shown to play key roles various development processes, including acting as scaffolding molecules with other proteins. However, proteins not yet systematically analyzed Cucurbita maxima. In study, 231 (CmWD40s) were C. maxima classified into five clusters. Eleven subfamilies based on different conserved motifs structures. The CmWD40 genes...
Coronary artery disease (CAD) is characterized by insufficient vasculogenic response to ischemia, which typically accompanied dysfunction of endothelial outgrowth cells (EOCs). CXC chemokine receptor 7 (CXCR7) a key modulator the neovascularization EOCs perfusion defect area. However, mechanism underlying role in CAD-related abnormal vasculogenesis still not clear. Here, we investigated alteration EOCs-related capacity patients with CAD and its potential mechanism. Compared isolated from...
Establishing codon usage biases are crucial for understanding the etiology of central nervous system neurodegenerative diseases (CNSNDD) especially Alzheimers disease (AD) as well genetic factors. G and C ending codons strongly biased in coding sequences these proteins a result genomic GC composition constraints. On other hand, that identified translationally optimal major trend all end or G, suggesting translational selection should also be taken into consideration additional to...
Pumpkin (
Abstract Przevalski’s partridge ( Alectoris magna ) is one of the birds in genus endemic to China. The distribution A. was narrow, and it only found parts Qinghai, Gansu, Ningxia provinces. considered a monotypic species until distinguished into two subspecies. However, external morphological characteristics, rather than genetic differences or evolutionary relationships, are now commonly used as evidence subspecies differentiation. In this study, chromosome-level reference genome has been...
Invertases and their inhibitors play important roles in sucrose metabolism, growth development, signal transduction, biotic abiotic stress tolerance many plant species. However, cucumber, both the gene members functions of invertase its inhibitor families remain largely unclear. In this study, comparison with orthologues Citrullus lanatus (watermelon), Cucumis melo (melon), Arabidopsis thaliana (Arabidopsis), 12 genes were identified from genome sativus (cucumber). Among them, classified as...