A5063125716- Mosquito-borne diseases and control
- Viral Infections and Vectors
- SARS-CoV-2 and COVID-19 Research
- Malaria Research and Control
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- Hepatitis C virus research
- Dengue and Mosquito Control Research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Intramuscular injections and effects
- Viral gastroenteritis research and epidemiology
- Computational Drug Discovery Methods
- Animal Virus Infections Studies
- Insect symbiosis and bacterial influences
- Bacteriophages and microbial interactions
- Viral Infections and Outbreaks Research
- SARS-CoV-2 detection and testing
- Viral Infections and Immunology Research
- Insect Resistance and Genetics
- Agricultural pest management studies
- Bacillus and Francisella bacterial research
- Respiratory viral infections research
- vaccines and immunoinformatics approaches
- Vector-Borne Animal Diseases
Sharda University
2022-2025
National Institute of Malaria Research
2018
All India Institute of Medical Sciences Jodhpur
2018
Sarojini Naidu Medical College
2018
Amity University
2017-2018
National Institute for Implementation Research on Non-Communicable Diseases
2008-2018
Indian Council of Medical Research
2008-2016
Dengue Fever and Hemorrhagic (DHF) stands as the principal cause of prolonged illness death among individuals all age groups. The screening mosquitoes from risk areas identification virus types present can offer crucial epidemiological insights regarding potential DHF. Therefore, to prove this an investigation was carried out on various dengue within field-collected Aedes in urban, rural peri-urban Jodhpur, Rajasthan, India. Adult were captured human residences outskirts. Individual...
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has emerged as one of the worst viral pandemics during past few years. As reported by World Health Organization, around 77,56 49 520 cases and 70 51 720 deaths were from all over world, which includes approximately 3500 patients recent only. Currently, circulating variants SARS-CoV-2 are KP.3, JN.1, BA.2.86 KP.2. Mass vaccinations have been provided since end December 2020, led to 5.47 billion people vaccinated till date. However,...
Dengue viruses are transmitted to humans through the bites of infected female aedine mosquitoes. Differences in composition and structure bacterial communities midguts mosquitoes may affect vector's ability transmit disease. To investigate analyse role midgut viral transmission, bacteria from three species, namely Stegomyia aegypti (= Aedes aegypti), Fredwardsius vittatus vittatus) albopicta albopictus) (all: Diptera: Culicidae), dengue-endemic non-endemic areas Rajasthan, India were...
First study on the complete genome characterization of Dengue-3 virus is reported from dengue endemic state Rajasthan, India. The 10,672 base pairs was studied with reference to global and regional genomes virus. 388 variations were observed in nucleotide sequences NCBI genome, including 34 amino acids. Of these AA variations, 4 showed substitution Envelope proteins 1 Anchored capsid region. remaining 29 acids constituting non structural (NS) proteins. mutations, especially those leading...
Objective: The severe acute type of respiratory distress caused by Coronavirus disease 2019 (COVID-19) was responsible for the global pandemic 2019. While most focus vaccine/drug molecules is on receptor, there are certain enzymes that also need to be checked. Cell surface proteases one these. Activation virus spike protein becomes more complicated when many host involved. As Variants Concerns have been reported in syndrome coronavirus 2 (SARS-CoV-2), this study aimed understand proteolytic...
BACKGROUND: The comparative understanding between cellular basis of transmission and clinical severities caused by Wuhan, Delta Omicron strains SARS-CoV-2 is important. OBJECTIVE: To conduct In-Vitro studies on infection different variants performing cytotoxic assays studying the live microscopic observations. METHODS: swab samples positive for were inoculated in Vero cell lines their rate infectivity nature cytopathy was observed. RESULTS: study showed maximum inter connectivity among cells...
Levels of C-Reactive Protein (CRP) serve as indicators inflammation and disease severity. During the pandemic COVID-19, many severe patients had shown increased levels CRP. Few studies have also indicated role CRP among subjects vaccinated by COVID-19 vaccines. In this present study, we report study Covishield Covaxin. The was made under five categories post viz; Not Infected-Non Vaccinated; Infected-Vaccinated-Reinfected; Post Vaccinated Infected; Infected-Vaccinated Non...
Background: Whole virion (attenuated) vaccine (Covaxin) and m-RNA of whole Spike protein (Covishield) were used as emergency measures in SARS-CoV-2 infection. Aim & Objective: To evaluate the antigenicity both vaccines by measuring quantum antibodies. Methods Material: Periodic post-vaccination i.e. after 5-6 11-12 months was undertaken two categories; those who not infected vaccinated secondly got re-infected (after vaccination). Results: Both categories patients showed similar IgA/IgG/...
Severe Acute Respiratory Syndrome Coronavirus-2 has been impacting human health since its first outbreak in December, 2019 Wuhan province of China. The virus naïve form undergone multiple changes then. However, the vaccine possesses specific set proteins which being artificially prepared, will not tend to change. In present study, we have aimed analyze genomic mutations and altered study their efficacy with respect available vaccines. A meta-analysis was conducted identify reported from...
Hepatitis C virus is one of the leading cause serious complications, cirrhosis and cancer liver. The RNA encodes for 10 proteins each playing an important role either as structural or non-structural component. which a member Flavivirus family, considered to be only associated with progression Cancer, still remains question many researchers. Studies are ongoing in looking into how various viral protein interacts subduing normal function liver cells, but transformation events also remain fully...
Hepatitis C virus infection has become a major health problem affecting approximately 170 million people every year. Also around 350,000 die year due to this virus. In India, 6-12 get infected with Different studies have reported the role of viral proteins mainly Core, NS3, NS5B in progressing Hepato-Cellular Carcinoma but exact cause and effect relationships are not known. A meta-analysis was first conducted using web tools data published last 25 years. Secondly silico work also correlated...
Coronaviruses are RNA viruses which were first identified as chicken infections way back in the year 1920 from North America. Of seven Human Coronavirus species, three viz. SARS-CoV-1, MERS-CoV and SARS-CoV-2 have caused severe diseases. Low titre of neutralizing antibodies was seen case SARS-COV-2 found previous infection 2002-2003 i.e. SARS-CoV-1. When genome profile current compared with older strains, it showed forty percent similarity MERS CoV. This indicates that origin is basically...
Hepatitis C virus infection is one of the main causes liver disease that can lead to cirrhosis and finally chronic development Hepatocellular Carcinoma (HCC). With 8 different HCV genotypes circulating, it becomes necessary characterize pathogenesis caused by each infecting population a particular setting. Present study aims identify circulating (HCV) in areas State Uttar Pradesh, India understand their clinical etiology related co-morbidities. The patients reporting Sharda Hospital, who...
Chronic Hepatitis C virus (HCV) infection is closely associated with cirrhosis and the prospective risk of Hepato-Cellular-Carcinoma (HCC). The long-term duration required for HCV transforming into HCC necessitates thorough study various co-morbidities patients, some which may act as predictors HCC. Present paper reports among patients. This a hospital-based study. patients reporting to Outdoor Patient Department (OPD) Sharda hospital, Greater Noida, UP, India were enrolled Total number 134...
In India and other affected countries, Omicron variant of SARS-CoV-2 has shown faster transmission but less clinical severities when compared to Delta strain. Present study was aimed investigate how molecular changes in the spike proteins increased its reduced disease severity. We report interactions Spike variants with ACE-2 receptor explain change chemical physical nature mutated amino acids internalization competence virus into host cell. The Research Collaboratory Structural...