A5029880491- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Immune Response and Inflammation
- vaccines and immunoinformatics approaches
- T-cell and B-cell Immunology
- Allergic Rhinitis and Sensitization
- RNA Research and Splicing
- Genetic Neurodegenerative Diseases
- Dermatology and Skin Diseases
- Food Allergy and Anaphylaxis Research
- Neurogenetic and Muscular Disorders Research
- Herpesvirus Infections and Treatments
- HIV Research and Treatment
- Pediatric health and respiratory diseases
- Mycotoxins in Agriculture and Food
- Diabetes and associated disorders
- Asthma and respiratory diseases
- Eosinophilic Esophagitis
- Cell Adhesion Molecules Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Mitochondrial Function and Pathology
- Phagocytosis and Immune Regulation
- Respiratory viral infections research
- Complement system in diseases
AstraZeneca (Spain)
2025
Universidad Complutense de Madrid
2017-2024
Instituto de Salud Carlos III
2020-2021
Biomedical Research Networking Center on Neurodegenerative Diseases
2020-2021
Centro de Biología Molecular Severo Ochoa
2020-2021
Universidad Autónoma de Madrid
2020-2021
Correction of mis-splicing events is a growing therapeutic approach for neurological diseases such as spinal muscular atrophy or neuronal ceroid lipofuscinosis 7, which are caused by splicing-affecting mutations. Mis-spliced effector genes that do not harbour mutations also good candidate targets in with more complex aetiologies cancer, autism, dystrophies neurodegenerative diseases. Next-generation RNA sequencing (RNA-seq) has boosted investigation global diseased tissue to identify key...
The oral mucosa is a first line of defense against pathogenic organisms and yet tolerates food antigens resident bacteria. Mucosal epithelial cells are emerging as important regulators innate adaptive immune responses. However, the contribution (OECs) determining immunity understudied. Here, we evaluated ability H413 TR146 cells, two cell (OEC) lines derived from human squamous carcinomas, primary OECs to modulate responses cocktail Gram+ Gram– bacteria known MV130. expressed CD40...
Polymerized allergoids conjugated with mannan represent a novel approach of allergen immunotherapy targeting dendritic cells. In this study, we aimed to determine the optimal dose mannan-allergoid conjugates derived from grass pollen (Phleum pratense and Dactylis glomerata) administered via either subcutaneous or sublingual route. A randomized, double-blind, placebo-controlled trial double-dummy design was conducted, involving 162 participants across 12 centers in Spain. Subjects were...
The phagocytic integrins and complement receptors αMβ2/CR3 αXβ2/CR4 are classically associated with the phagocytosis of iC3b-opsonized particles. activation this receptor is dependent on signals derived from other (inside-out signaling) crucial involvement Rap1-RIAM-Talin-1 pathway. Here, we analyze implication RIAM its binding partner VASP in signaling events occurring downstream β2 (outside-in) during complement-mediated phagocytosis. To end, used HL-60 promyelocytic cell lines deficient...
The oral mucosa is constantly exposed to a plethora of stimuli including food antigens, commensal microbiota and pathogens, requiring distinct immune responses. We previously reported that human epithelial cells (OECs) suppress responses bacteria, using H413 TR146 OEC lines primary OECs in co-culture with dendritic (DCs) T (OEC-conditioned cells). reduced DCs expression CD80/CD86 IL-12/TNFα release impaired cell activation. Here, we further evaluated the immunosuppression by these...
Human Rhinovirus (HRV) is a major cause of common cold, bronchiolitis, and exacerbations chronic pulmonary diseases such as asthma. CD8 T cell responses likely play an important role in the control HRV infection but, surprisingly, HRV-specific epitopes remain yet to be identified. Here, we approached discovery characterization conserved from species A (HRV A) C C), most frequent subtypes clinics various diseases. We found IFNγ-ELISPOT positive 23 peptides on peripheral blood mononuclear...
Type 1 diabetes (T1D) results from the destruction of pancreatic β-cells by immune system, and CD8+ T lymphocytes are critical actors in this autoimmune response. Pancreatic islets surrounded a mesh nervous cells, peri-insular Schwann which also targeted autoreactive express specific antigens, such as neurotrophic factor S100-β. Previous work has shown increased proliferative responses to whole S100-β both human T1D patients nonobese diabetic (NOD) mouse model. We describe for first time...
Abstract Deregulated alternative splicing has been implicated in a wide range of pathologies. Deep RNA-sequencing revealed global mis-splicing signatures multiple human diseases; however, for neurodegenerative diseases, these analyses are intrinsically hampered by neuronal loss and neuroinflammation post-mortem brains. To infer alterations relevant to Huntington’s disease (HD) pathogenesis, here we performed intersect-RNA-seq striatal tissue an early symptomatic mouse model which gliosis not...
Background : Polymerized allergoids conjugated with mannan represent a novel approach of allergen immunotherapy targeting dendritic cells. In this study, we aimed to determine the optimal dose mannan-allergoid conjugates derived from grass pollen ( Phleum pratense and Dactylis glomerata ) administered via either subcutaneous or sublingual route. Methods A randomized, double-blind, placebo-controlled trial double-dummy design was conducted, involving 162 participants across 12 centers in...