A5102791141- Computational Drug Discovery Methods
- Alzheimer's disease research and treatments
- Protein Structure and Dynamics
- Adolescent and Pediatric Healthcare
- Circadian rhythm and melatonin
- Free Radicals and Antioxidants
- Oxidative Organic Chemistry Reactions
- Adolescent Sexual and Reproductive Health
- Family Support in Illness
- Pharmacological Effects of Natural Compounds
- Attachment and Relationship Dynamics
- Autophagy in Disease and Therapy
- Aldose Reductase and Taurine
- Cholinesterase and Neurodegenerative Diseases
- Organic Chemistry Cycloaddition Reactions
- Human-Animal Interaction Studies
- Calcium signaling and nucleotide metabolism
- Childhood Cancer Survivors' Quality of Life
- Synthesis and Biological Evaluation
- Sirtuins and Resveratrol in Medicine
- Gender, Feminism, and Media
- Biochemical and Molecular Research
- Synthesis of Organic Compounds
- Poisoning and overdose treatments
Roanoke College
2021
Purdue University West Lafayette
2011-2019
Portland State University
2014
Center for Cancer Research
2011-2012
A variety of ammosamide B analogues have been synthesized and evaluated as inhibitors quinone reductase 2 (QR2). The potencies the resulting series QR2 range from 4.1 to 25,200 nM. data provide insight into structural parameters necessary for inhibitory activity. natural product proved be a potent inhibitor, generally decreased their structures became more distinct that B. Methylation 8-amino group was an exception, in increase activity IC50 61 nM
BACE1 (Beta-site Amyloid Precursor Protein (APP) Cleaving Enzyme 1) is a promising therapeutic target for Alzheimer's Disease (AD). However, efficient expression, purification, and crystallization systems are not well described or detailed in the literature nor approaches treatment of enzyme kinetic data potent inhibitors described. We therefore developed platform expression purification BACE1, including protein refolding from E.coli inclusion bodies, addition to optimizing reproducible...
Emerging adults (EAs) use many phrases to refer their romantic interactions. In two studies (N1 = 110; N2 222), EAs' knowledge and perceptions of "talking" were examined. Study 1, a majority college students had heard "talking," perceived as distinct from "friends with benefits" (FWB) dating. 2, about half broader EA sample being significantly less emotionally physically intimate, committed than dating; they did, however, be similar in some ways FWB. Additionally, EAs varied agreement...
BACE1 (Beta‐site Amyloid precursor protein (APP) Cleaving Enzyme 1) is a promising therapeutic target for Alzheimer's disease (AD). However, efficient expression, purification and crystallization systems are not well described or detailed in the literature nor approaches treatment of enzyme kinetic data tight‐binding inhibitors described. Therefore, we have developed platform expression BACE1, including refolding from inclusion bodies, E. coli addition to reproducible procedure bound with...