A5020984429- Parasite Biology and Host Interactions
- Parasitic Diseases Research and Treatment
- Evolution and Genetic Dynamics
- Insects and Parasite Interactions
- Insect symbiosis and bacterial influences
- Nematode management and characterization studies
- Helminth infection and control
- Toxoplasma gondii Research Studies
- Aquatic Invertebrate Ecology and Behavior
- Coccidia and coccidiosis research
- Marine Bivalve and Aquaculture Studies
- Genetic diversity and population structure
- Protist diversity and phylogeny
- Parasitic Infections and Diagnostics
- Zoonotic diseases and public health
- Venomous Animal Envenomation and Studies
- Parasites and Host Interactions
- Insect and Arachnid Ecology and Behavior
- Ocular Diseases and Behçet’s Syndrome
- Human Health and Disease
- Veterinary medicine and infectious diseases
- Monoclonal and Polyclonal Antibodies Research
- Hemiptera Insect Studies
- Parasitic infections in humans and animals
- Vitamin D Research Studies
Agricultural Research Service
2014-2025
Beltsville Agricultural Research Center
2017-2024
United States Department of Agriculture
2014-2024
Oak Ridge Associated Universities
2018
Oak Ridge Institute for Science and Education
2018
Bioscience Research
2014
University of Maryland, College Park
2011-2014
Avon (United States)
2014
National University of Singapore
2006
Understanding parasite diversity and distribution is essential in managing the potential impact of parasitic diseases animals people. Imperfect diagnostic methods, however, may conceal cryptic species. Here, we report discovery phylogeography a previously unrecognized species Trichinella wolverine (Gulo gulo) from northwestern Canada that was indistinguishable T. nativa using standard multiplex PCR assay based on expansion segment 5 (ESV) ribosomal DNA. The novel genotype, designated as T13,...
Ostertagia ostertagi, also known as the brown stomach worm, causes significant pathology in abomasum, resulting production and nutritional losses cattle. Alternative control measures, such vaccination, are urgently needed because of rapidly growing anthelmintic drug resistance. There is a need to understand host responses infection, especially immune responses, advance vaccine discovery design. Therefore, present study investigated comprehensive changes gene transcription abomasal mucosa...
Trichinella murrelli Pozio and La Rosa, 2000, is the primary sylvatic trichinellid encountered in temperate North America. During a survey for Sarcocystis wild canids, single worm matching morphology of encapsulated was observed muscle tissue squash from gray fox male originating Pennsylvania. The photographed then separated host by artificial digestion, genomic DNA extracted worm. This subjected to species-specific multiplex PCR short-read sequencing. banding pattern indicated that T....
Species of Trichinella are a globally distributed assemblage nematodes, often with distinct host ranges, which include people, domestic, and wild animals. spp. important in northern Canada, where dietary habits people methods meat preparation (drying, smoking, fermenting as well raw) increase the risk posed by these foodborne zoonotic parasites. Outbreaks arctic subarctic regions Canada United States generally attributed to T. nativa (T2) or T6 genotype, when genetic characterization is...
Parasitic and symbiotic relationships govern vast nutrient energy flows, yet controversy surrounds their longevity. Enduring may engender parallel phylogenies among hosts parasites, but so ephemeral when parasites colonize related hosts. An understanding of whether symbiont host populations have grown contracted in concert would be useful considering the temporal durability these relationships. Here, we devised methods to compare demographic histories derived from genomic data. We compared...
Species of Trichinella are globally important foodborne parasites infecting a number domestic and wild vertebrates, including humans. Free-ranging carnivores can act as sentinel species for detection spp. Knowledge the epidemiology these may help prevent infections in northern Canadian animals people. Previous research on wildlife from Yukon did not identify risk factors associated with infection, or diversity identity regional circulation, based geographically extensive sampling large...
Horizontal gene transfer (HGT) has played an important role in the evolution of nematodes. Among candidate genes, cyanase, which is typically found only plants, bacteria and fungi, present more than 35 members Phylum Nematoda, but absent from free-living clade V organisms. Phylogenetic analyses showed that cyanases I organisms Trichinella spp., Trichuris spp. Soboliphyme baturini (Subclass: Dorylaimia) represent a well-supported monophyletic with plant cyanases. In contrast, all within...
What is already known about this subject • Genetic variability of the FcγRIIIa 176 F/V polymorphism has been widely studied in patients with systemic lupus erythomatosus and rheumatoid arthritis, as well general population various White groups. Its implications disease pathogenesis response to therapeutics have documented. This study aimed profile its pattern Asian population, thus it serves useful reference controls association studies tailoring therapy ethnic‐specific populations. adds In...
As the agent of Dermo disease, Perkinsus marinus causes significant mortality and reduced fecundity its eastern oyster host, Crassostrea virginica. Passive dispersal P. between hosts subjects parasite movements to control by water currents in estuarine systems, potentially limiting connectivity among populations different estuaries. Given recent evidence for sexual reproduction marinus, estimates gene flow locations may provide insights into this parasite's epidemiology. In study, 1,082 wild...
The management of the Canadian fisheries is under authority both federal and provincial governments. While it common to confederation that levels government have dual roles in many areas life, situation with respect tends be more complicated intricacies federal–provincial jurisdiction. result has led at times a genuine confusion as prerogatives over fisheries.In order manage resource considered requisite an understanding legislative agencies responsible for fisheries. Such will serve outline...
Hybridization between two closely related but distinct genetic lineages may lead to homogenization of the with potentially novel phenotypes, or selective pressure avoid hybridization if are truly distinct. Trichinella nativa and T6 zoonotic nematode parasites which can be distinguished genetically despite occasional hybridization. Here, using an experimental murine model, we attempt determine whether there barriers when sizeable numbers each lineage allowed coinfect a host. Two mice were...
Genome assemblies can form the basis of comparative analyses fostering insight into evolutionary genetics a parasite's pathogenicity, host-pathogen interactions, environmental constraints and invasion biology; however, length complexity many parasite genomes has hampered development well-resolved assemblies. In order to improve Trichinella genome assemblies, sylvatic encapsulated species murrelli was sequenced using third-generation, long-read technology and, syntenic comparisons, scaffolded...
Available evidence suggests that Trichinella spiralis first originated in Asia and subsequently spread to the rest of world. Notably limited genetic diversity European T. isolates indicates parasite went through a dramatic bottleneck at some point its history. Did this result from transport number infected pigs Asian centers domestication, or was resident Europe far earlier than domestication there? In order explore hypothesis, we generated complete mitochondrial genomes ribosomal DNAs...
Trichinella spiralis ranks seventh in the risk posed by foodborne parasites. It causes most human cases of trichinellosis and is frequent cause outbreaks on pig farms wild boar, worldwide. Veterinary inspectors seek source hopes limiting spread. Established molecular tools are inadequate for distinguishing among potential T. infection sources because genetic variability these zoonotic pathogens limited Europe. Microsatellite markers proved successful tracing an outbreak britovi, a related...
Molecular epidemiology using traditional sequencing has been notoriously difficult in inbred parasites due to a lack of genetic variation available for discriminating among parasites. Next generation techniques offer solution this problem by increasing the number loci that can be sequenced. Here, we introduce Trich-tracker, tool makes efficient use diagnostic distributed throughout genome Trichinella spiralis more rapidly, and conclusively, resolve connections distinctions focal outbreaks T....
Evolution involves temporal changes in the characteristics of a species that are subsequently propagated or rejected through natural selection. In case parasites, host switching also plays prominent role evolutionary process. These rooted genetic variation and gene flow where genes may be deleted, mutated (sequence), duplicated, rearranged and/or translocated then transmitted vertical transfer. However, introduction new is not driven only by Mendelian inheritance mutation but DNA from...