A5085569145- Eicosanoids and Hypertension Pharmacology
- Polyoxometalates: Synthesis and Applications
- Crystal Structures and Properties
- Neurobiology and Insect Physiology Research
- Field-Flow Fractionation Techniques
- Metal-Organic Frameworks: Synthesis and Applications
- Genomics, phytochemicals, and oxidative stress
- Organic Chemistry Cycloaddition Reactions
- Synthesis and Biological Evaluation
- Fatty Acid Research and Health
- Bioactive Compounds and Antitumor Agents
- Synthesis and Reactions of Organic Compounds
- Chemical Thermodynamics and Molecular Structure
- Synthesis and Catalytic Reactions
- Fluorine in Organic Chemistry
- Synthesis and biological activity
- Cyclone Separators and Fluid Dynamics
- Enzyme Structure and Function
- Lipid metabolism and biosynthesis
- Advanced Condensed Matter Physics
- Mining and Gasification Technologies
- Cholesterol and Lipid Metabolism
- Industrial Engineering and Technologies
- Free Radicals and Antioxidants
- Enzyme Catalysis and Immobilization
MIREA - Russian Technological University
2018-2023
Academy of Sciences Republic of Uzbekistan
2021
Songho University
2021
Industrial University of Tyumen
2021
Czech Academy of Sciences, Institute of Geology
2021
Moscow State University of Fine Chemical Technologies
2006-2018
Lomonosov Moscow State University
2006-2015
Mixed sodium nickel hydroxide phosphate, Na2Ni3(OH)2(PO4)2, has been synthesized hydrothermally from the system NiCO3-Na4P2O7-NaCl-H2O. Its monoclinic crystal structure determined by single X-ray diffraction: a = 14.259(5), b 5.695(2), c 4.933(1) Å, β 104.28(3)°, space group C2/m, Z 2, ρc 3.816 g cm(-3), R 0.026. The underlying spin model characterized in terms of first-principles electronic calculations. compound is formed alternating layers [NiO6] octahedra and [NaO7] polyhedra, combined...
Here, we describe the first systematic study on mechanism of substrate-selective inhibition mammalian ALOX15 orthologs. For this purpose, prepared a series N-substituted 5-(1H-indol-2-yl)anilines and found that (N-(5-(1H-indol-2-yl)-2-methoxyphenyl)sulfamoyl)carbamates their monofluorinated analogues are potent selective inhibitors linoleate oxygenase activity rabbit human ALOX15. Introduction 2-methoxyaniline moiety into core pharmacophore plays crucial role in ALOX15-catalyzed oxygenation...
For the specificity of ALOX15 orthologs different mammals, geometry amino acids Phe353, Ile418, Met419, and Ile593 ("triad determinants") is important, mutagenesis these residues altered reaction enzymes. Here we expressed wild-type human ALOX5 its F359W/A424I/N425M/A603I mutant in Sf9 insect cells characterized catalytic differences two enzyme variants. We found that converted arachidonic acid mainly to 5(S)-hydroperoxyeicosatetraenoic (HpETE). In contrast, 15(S)- 8(S)-H(p)ETE were formed...
A new compound, Rb2Cu3(P2O7)2, has been obtained from the melt in Rb–Cu–P–O system. Its monoclinic crystal structure was determined by single-crystal X-ray diffraction: space group P21/c, Z = 2, a 7.7119(8) Å, b 10.5245(9) c 7.8034(9) β 103.862(5)° at 293 K, R 0.030. The copper ions show coordination number (CN) 6 (4+2, distorted tetragonal bipyramidal). Trimers of [CuO6] polyhedra sharing cis-edges form together with diphosphate groups two tetrahedra [P2O7] microporous 3D framework channels...
Mammalian 15-lipoxygenases (ALOX15) are lipid peroxidizing enzymes that exhibit variable functionality in different cancer and inflammation models. The pathophysiological role of linoleic acid- arachidonic acid-derived ALOX15 metabolites rendered this enzyme a target for pharmacological research. Several indole imidazole derivatives inhibit the catalytic activity rabbit substrate-specific manner, but molecular basis allosteric inhibition remains unclear. Here, we attempt to define common...
RS75091 is a cinnamic acid derivative that has been used for the crystallization of rabbit ALOX15-inhibitor complex. The atomic coordinates resolved ALOX15- inhibitor complex were later on to define binding sites other mammalian lipoxygenase orthologs, which no direct structural data with ligand reported so far.The putative pocket human ALOX5 was reconstructed basis its alignment ALOX15-RS75091 inhibitor. However, considering possible conformational changes enzyme may undergo in solution, it...
Abstract Non‐centrosymmetric orthorhombic single crystals of Cs 2 Cu 1.1 (VO) 1.9 (P O 7 ) are obtained by spontaneous crystallization from a melt containing CsH PO 4 , CuO, and V 5 in the molar ratio 2:2:1 (Al 3 crucible, 850 °C, 72 h).
Mammalian 15-lipoxygenases (ALOX15) are enzymes of lipid peroxidation. The pathophysiological role ALOX15 metabolites, linoleic acid and arachidonic derivatives, has made this enzyme a target for pharmacological studies. Several indole benzimidazole derivatives inhibit the activity in substrate-specific manner, but molecular basis allosteric inhibition remains unclear.
Research studies have been carried out under laboratory conditions with the aimto increase of yield fuel fractions during distillation extra light oil, which was activated in advance vortex bed reactor. It is shown a possibility target products from 62.5% wt. to 71.3% processing time up 240 seconds. achieved because conversion not only asphaltenes and resins but also high-molecular hydrocarbons feed.